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  1. 2121
    “…The genes most frequently involved were KRAS (28%), TP53 (18%), ARID1A (12%), IDH1/2 (9%), PBRM1 (9%), BAP1 (7%), and PIK3CA (7%). …”
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    Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups
  2. 2122
    “…Epigenetic regulators (IDH1 and YEATS2) and an activin/BMP signal component (ACVR2A) were recurrently altered. …”
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    Unique mutation portraits and frequent COL2A1 gene alteration in chondrosarcoma
  3. 2123
    “…Induction of G-CIMP+ state by exogenous expression of a mutated isocitrate dehydrogenase 1, IDH1-R132H, suppressed EGFR and H-Ras protein expression as well as pERK accumulation in independent glioblastoma models. …”
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    Epigenetic suppression of EGFR signaling in G-CIMP+ glioblastomas
  4. 2124
    “…Furthermore our OncoPanel analysis revealed that 15% of IDH1/2 mutant gliomas would not be detected by traditional IDH1 (p.R132H) antibody testing, supporting the use of genomic technologies in providing clinically relevant data. …”
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    Clinical multiplexed exome sequencing distinguishes adult oligodendroglial neoplasms from astrocytic and mixed lineage gliomas
  5. 2125
    “…The glucose-6-phosphate dehydrogenase (G6PD), gamma-glutamyl cyclotransferase (GGCT), isocitrate dehydrogenase 1 (NADP+,soluble)(IDH1), isocitrate dehydrogenase 2 (NADP+,mitochondrial) (IDH2) and glutathione S-transferase pi 1(GSTP1), five of the critical components of GSH pathway, contribute to chemoresistance.…”
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    Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis
  6. 2126
    “…More recently described biomarkers, including the non-balanced translocation leading to 1p/19q codeletion, promoter hypermethylation of the MGMT gene, mutations of the IDH1 or IDH2 gene, and mutations of FUBP1 (on 1p) or CIC (on 19q), have greatly enhanced our understanding of oligodendroglioma biology, although their diagnostic, prognostic, and predictive roles are less clear. …”
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    Oligodendroglioma: pathology, molecular mechanisms and markers
  7. 2127
    “…The importance of the TET-mediated cytosine demethylation pathway is also underscored by a recurrent mutation of isocitrate dehydrogenase 1 (IDH1) and IDH2 in hematological malignancies, whose mutation inhibits TET function through a novel oncometabolite, 2-hydroxyglutarate. …”
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    TET2 as an epigenetic master regulator for normal and malignant hematopoiesis
  8. 2128
    por Dvinge, Heidi, Bradley, Robert K.
    Publicado 2015
    “…The extent of intron retention correlated with the presence of IDH1 and IDH2 mutations in acute myeloid leukemia and across molecular subtypes in breast cancer. …”
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    Widespread intron retention diversifies most cancer transcriptomes
  9. 2129
    “…After the drainage of chronic subdural hematomas (CSDHs), residual isolated deep-seated hematomas (IDHs) may recur. We introduce intraoperative ultrasonography to detect and remove such IDHs. …”
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    Intraoperative Ultrasonography during Drainage for Chronic Subdural Hematomas: A Technique to Release Isolated Deep-seated Hematomas—Technical Note
  10. 2130
    “…Transcriptome analysis indicated that expression of genes involved in the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YΔGP/XK/XI strain. …”
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    Disruption of PHO13 improves ethanol production via the xylose isomerase pathway
  11. 2131
    “…Gene mutations of signaling pathways occurred in 63.3% of patients, with FLT3-ITD (44.9%) and FLT3-TKD (13.3%) being the most frequent. 66% of patients had gene mutations involving epigenetic regulation, and DNMT3A (32.7%), IDH2 (18.4%), TET2 (18.4%), and IDH1 (10.2%) mutations were most common. …”
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    High frequency of additional gene mutations in acute myeloid leukemia with MLL partial tandem duplication: DNMT3A mutation is associated with poor prognosis
  12. 2132
    “…Six patients (33%) had MGMT methylation but IDH1 mutation was found in only one patient (6%). …”
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    Malignant Glioma with Neuronal Marker Expression : A Clinicopathological Study of 18 Cases
  13. 2133
    “…The prevalence of mutant isocitrate dehydrogenase 1 (IDH1) brain tumors has generated significant efforts to understand the role of the mutated enzyme product d-2-hydroxyglutarate (D2HG), an oncometabolite, in tumorigenesis, as well as means to eliminate it. …”
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    Intracerebral Distribution of the Oncometabolite d-2-Hydroxyglutarate in Mice Bearing Mutant Isocitrate Dehydrogenase Brain Tumors: Implications for Tumorigenesis
  14. 2134
    “…One such example is the induction of carcinogenesis by the oncometabolite D-2 hydroxyglutarate (D-2HG), which is produced by the mutated enzyme isocitrate dehydrogenase (IDH) occurring in subsets of leukaemias and brain tumours. …”
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    Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer
  15. 2135
    por Chong, Dawn Q., Zhu, Andrew X.
    Publicado 2016
    “…FGFR2 and ROS1) and somatic mutations (e.g. IDH1/2), which are promising actionable molecular targets.…”
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    The landscape of targeted therapies for cholangiocarcinoma: current status and emerging targets
  16. 2136
    “…In cell lines and patient samples harboring IDH1/IDH2 (Isocitrate dehydrogenase 1 and 2) mutations, CB-839 reduced production of oncometabolite 2-hydroxyglutarate, inducing differentiation. …”
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    Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes
  17. 2137
    “…Mutant IDH1 (R132H) cells were also not detected in the autopsy specimens of the brain by polymerase chain reaction analysis.…”
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    Anaplastic astrocytoma cells not detectable on autopsy following long-term temozolomide treatment: A case report
  18. 2138
    “…One hundred and seven patients (49.3%) had no significant change in BP; 30.9% had intradialytic hypertension (IDHT) while 19.8% had intradialytic hypotension (IDH). IDH was more prevalent among patients with diabetic kidney disease while IDHT was more common among patients with hypertensive nephropathy (P = 0.002). …”
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    Blood Pressure Variation and Its Correlates among Patients Undergoing Hemodialysis for Renal Failure in Benin City, Nigeria
  19. 2139
    “…BACKGROUND: Chronic refractory hypotension (IDH, intradialytic hypotension) is a rare but serious problem encountered in patients on hemodialysis. …”
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    Beneficial effect of kidney transplantation from a deceased donor on severe chronic refractory intradialytic hypotension – a case report
  20. 2140
    “…Direct regulation of LOX, IDH1 and AVEN by miR-30a was confirmed in human keratinocytes. …”
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    An expression screen for aged-dependent microRNAs identifies miR-30a as a key regulator of aging features in human epidermis
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