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  1. 2161
    “…The reported two cases were initially diagnosed as oligodendroglioma with 1p/19q-codeletion and mutation of isocitrate dehydrogenase 1 (IDH1)-R132H. The recurrent tumors showed loss of alpha-thalassemia/mental retardation X-linked (ATRX) expression, strong P53 positivity, and 1p/19q-nondeletion. …”
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    Recurrent Glioma With Lineage Conversion From Oligodendroglioma to Astrocytoma in Two Cases
  2. 2162
    “…High-glucose stimulation in cultured proximal tubular cells also resulted in an increase in acetylated IDH2/SOD2, CD38 overexpression and a reduction in the NAD(+)/NADH ratio. …”
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    Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats
  3. 2163
    “…Through integrating the advantages and disadvantages of three independent predictors, the tumor mutation index (TMI) is established as a prediction model and the patients who are very likely to benefit more from anlotinib therapy are identified. Furthermore, the IDH1 (exon 4) mutation is identified as an unfavorable factor for anlotinib therapy under TMI‐based stratification, and the TMI plus IDH1 (exon 4) mutation status potentially predicts response to anlotinib. …”
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    Circulating DNA‐Based Sequencing Guided Anlotinib Therapy in Non‐Small Cell Lung Cancer
  4. 2164
    “…These tumors are defined by recurrent mutations in the IDH genes and other genetic alterations including inactivation of CDKN2A and COL2A1; however, these have no clinical value. …”
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    Integrated molecular characterization of chondrosarcoma reveals critical determinants of disease progression
  5. 2165
    “…Neoantigen-specific T-cell responses have also been identified for peptides derived from mutated isocitrate dehydrogenase (IDH(mut)), and specific T-cell responses could be induced by IDH(mut) peptide vaccination. …”
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    Neoantigens in Hematological Malignancies—Ultimate Targets for Immunotherapy?
  6. 2166
    “…This study emphasises SEL1L as a potential biomarker for the most common subgroup of TERT mutant/EGFR amplified/IDH‐WT GBs.…”
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    SEL1L plays a major role in human malignant gliomas
  7. 2167
    “…Results showed statistically significant survival increase in four groups: (1) patients treated with gross total resection (GTR) (p < 0.030); (2) patients with mutation of IDH1 (p < 0.0161); (3) patients with methylated MGMT promoter (p < 0.005); (4) patients without EGFR amplification or EGFRvIII mutation (p < 0.035). …”
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    Retrospective and Randomized Analysis of Influence and Correlation of Clinical and Molecular Prognostic Factors in a Mono-Operative Series of 122 Patients with Glioblastoma Treated with STR or GTR
  8. 2168
    “…The analysis of clinical features of the samples showed that the higher the expression of ICGs, the more likely to be correlated with mutant isocitrate dehydrogenase (IDH), while the lower the expression level of IDH, the more likely to be significantly correlated with the primary GBM. …”
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    Identification of immunologic subtype and prognosis of GBM based on TNFSF14 and immune checkpoint gene expression profiling
  9. 2169
    “…Furthermore, GPR133 is expressed in both isocitrate dehydrogenase (IDH) wild-type and mutant gliomas, albeit at higher levels in IDH wild-type tumors. …”
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    Expression profiling of the adhesion G protein-coupled receptor GPR133 (ADGRD1) in glioma subtypes
  10. 2170
    “…A case of a true dual-genotype IDH-mutant oligoastrocytoma with two different cell types within a single mass in a young woman is presented. …”
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    A dual-genotype oligoastrocytoma with histologic, molecular, radiological and time-course features
  11. 2171
    “…Patients with low SKP2 expression, IDH1 mutation and wild-type TERT promoter demonstrated the longest survival time. …”
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    High S phase kinase-associated protein 2 expression is a potential prognostic biomarker for glioma
  12. 2172
    “…Increased infiltration of M1 macrophages was associated with a poor radiation response for IDH-wildtype GBM. Together, it will facilitate more precise stratifications of glioma patients based on molecular and immunological surrogates.…”
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    Increased M1 Macrophages Infiltration Correlated With Poor Survival Outcomes and Radiation Response in Gliomas
  13. 2173
    “…BACKGROUND: Glioblastoma (GBM) is known for its devastating intracranial infiltration and its unfavorable prognosis, while extracranial involvement is a very rare event, more commonly attributed to IDH wild-type (primary) GBM evolution. CASE PRESENTATION: We present a case of a young woman with a World Health Organization (WHO) grade II Astrocytoma evolved to WHO grade IV IDH mutant glioblastoma, with subsequent development of lymphatic and bone metastases, despite the favorable biomolecular pattern and the stability of the primary brain lesion. …”
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    Extracranial metastases in secondary glioblastoma multiforme: a case report
  14. 2174
    “…Moreover, the mutations in epigenetic genes such as DNMT3A, IDH1 or IDH2 are almost absent or rare in pediatric patients as compared to their abundance in adult AML. …”
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    DNA Methylation Clusters and Their Relation to Cytogenetic Features in Pediatric AML
  15. 2175
    “…This trend started with fine-tuning MRS for detecting intracellular 2HG in IDH-mutant astrocytomas and further expanded into a novel research field named “radiomics”. …”
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    SS-2 Current status and future perspective of radiomics in glioma imaging
  16. 2176
    “…Further analysis revealed ATRX retained, p53 immunoreactivity in 15–20% of nuclei, IDH1 and IDH2 wildtype, MGMT promoter not methylated, H3K27M wildtype, no 1p and/or 19q deletion/codeletion. …”
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    HGG-43. CONGENITAL GLIOBLASTOMA MULTIFORME: A CASE REPORT OF A RARE PEDIATRIC BRAIN TUMOR, MOLECULAR ANALYSIS, AND REVIEW OF THE LITERATURE
  17. 2177
    “…Expression quantitative trait loci (eQTL) analyses using nondiseased brain samples, isocitrate dehydrogenase 1 (IDH1) wild‐type glioma, and neurodevelopmental tissues showed STMN3 to be a consistent significant eQTL with rs3761124. …”
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    A functional variant on 20q13.33 related to glioma risk alters enhancer activity and modulates expression of multiple genes
  18. 2178
    “…The VEGF pathway analysis revealed nine upregulated (IL6, EGFR, VEGFA, SRC, CXCL8, PTGS2, IDH1, APP, and SQSTM1) and five downregulated hub genes (POLR2H, RPS3, UBA52, CCNB1, and UBE2C) linked with several of the VEGF signaling pathway components. …”
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    Identification of Hub Genes and Key Pathways Associated with Anti-VEGF Resistant Glioblastoma Using Gene Expression Data Analysis
  19. 2179
    “…We identify H3.3(G34R) and IDH1/2 mutations as two such factors in ATRX-mutated glioblastomas. …”
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    Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas
  20. 2180
    “…Meanwhile, the PeCS2, PeACO4, PeACO5 and PeIDH1 genes may play an important role in regulating the accumulation of citric acid. …”
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    Changes in the Content of Organic Acids and Expression Analysis of Citric Acid Accumulation-Related Genes during Fruit Development of Yellow (Passiflora edulis f. flavicarpa) and Purple (Passiflora edulis f. edulis) Passion Fruits
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