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Mostrando 201 - 220 Resultados de 4,168 Para Buscar '"IDH"', tiempo de consulta: 0.15s Limitar resultados
  1. 201
    “…BACKGROUND: Recent single-cell transcriptomic studies report that IDH-mutant gliomas share a common hierarchy of cellular phenotypes, independent of genetic subtype. …”
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    ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma
  2. 202
    “…Background and Objectives: The IDH (isocitrate dehydrogenase) status represents one of the main prognosis factors for gliomas. …”
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    External Validation of a Convolutional Neural Network for IDH Mutation Prediction
  3. 203
    “…Approximately half of chondrosarcomas harbor gain-of-function mutations in isocitrate dehydrogenase (IDH), and mutant IDH produces 2-hydroxyglutarate (2-HG), which is an oncometabolite that contributes to malignant transformation. …”
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    Clinical usefulness of 2-hydroxyglutarate as a biomarker in IDH-mutant chondrosarcoma
  4. 204
    “…Isocitrate dehydrogenase (IDH) mutation status is an important factor for surgical decision-making: patients with IDH-mutated tumors are more likely to have a good long-term prognosis, and thus favor aggressive resection with more survival benefit to gain. …”
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    Method for the Intraoperative Detection of IDH Mutation in Gliomas with Differential Mobility Spectrometry
  5. 205
    por Brandi, Giovanni, Rizzo, Alessandro
    Publicado 2022
    “…In this perspective article, we discuss available evidence regarding the interplay between TME, IDH inhibitors, and immunotherapy, providing rationale for the design of future clinical trials.…”
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    IDH Inhibitors and Immunotherapy for Biliary Tract Cancer: A Marriage of Convenience?
  6. 206
    “…Wild-type isocitrate dehydrogenase 1 (wtIDH1) has recently been implicated as a metabolic dependency in cancer. …”
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    Wild-type IDH1 inhibition enhances chemotherapy response in melanoma
  7. 207
    “…SIMPLE SUMMARY: In our study, the involvement of IDH1 in atherosclerotic foam cells was explored. …”
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    IDH1 Promotes Foam Cell Formation by Aggravating Macrophage Ferroptosis
  8. 208
    “…Introduction: Glioblastoma, IDH-wild type (GBM) is the most common malignant brain tumor with a dismal prognosis. …”
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    GEN-10 WHOLE GENOME LANDSCAPE OF GLIOBLASTOMA, IDH-WILD TYPE
  9. 209
    “…Necrosis and increased microvascular density in glioblastoma IDH-wild-type are the consequence of both hypoxia and cellular immaturity. …”
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    Implications of Cellular Immaturity in Necrosis and Microvascularization in Glioblastomas IDH-Wild-Type
  10. 210
    “…Mutations in IDH genes occur frequently in acute myeloid leukemia (AML) and other human cancers to generate the oncometabolite R-2HG. …”
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    Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance
  11. 211
    “…The CNS WHO grade 4 IDH-mutant astrocytomas did not always resemble methylation subclasses of higher grades. …”
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    Longitudinal DNA methylation analysis of adult-type IDH-mutant gliomas
  12. 212
    “…The World Health Organization recently revised the diagnosis of glioma, to integrate molecular parameters, including IDH mutations and codeletion (loss of heterozygosity; LOH) of chromosome arms 1p/19q, into the definitions of adult glioma histological subtypes. …”
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    Mass spectrometry-based assay for the molecular diagnosis of glioma: concomitant detection of chromosome 1p/19q codeletion, and IDH1, IDH2, and TERT mutation status
  13. 213
    “…PURPOSE: IDH1 and IDH2 are hotspot mutations commonly identified in WHO-grade 4 astrocytomas. …”
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    The Cancer Driver Genes IDH1 and IDH2 and CD204 in WHO-Grade 4 Astrocytoma: Crosstalk Between Cancer Metabolism and Tumour Associated Macrophage Recruitment in Tumour Microenvironment
  14. 214
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    Cerebrospinal fluid 2-hydroxyglutarate as a monitoring biomarker for IDH-mutant gliomas
  15. 215
    “…BACKGROUND: Isocitrate dehydrogenase (IDH) mutations are thought to represent an early oncogenic event in glioma evolution, found with high penetrance across tumor cells; however, in rare cases, IDH mutation may exist only in a small subset of the total tumor cells (subclonal IDH mutation). …”
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    The prognostic impact of subclonal IDH1 mutation in grade 2–4 astrocytomas
  16. 216
    “…A total of 98 patients with isocitrate dehydrogenase (IDH)-wild-type GB aged ≥65 years were analysed from January 2012 to January 2020. …”
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    Prognostic analysis and nomogram construction for older patients with IDH-wild-type glioblastoma
  17. 217
    “…We performed testing for residual IDH1 variants (IDH1m) in pre-transplant CR1 blood of 148 adult patients undergoing alloHCT for IDH1-mutated AML at a CIBMTR site between 2013–2019. …”
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    Measurable Residual IDH1 before Allogeneic Transplant for Acute Myeloid Leukemia
  18. 218
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    P555: OLUTASIDENIB IN POST-VENETOCLAX PATIENTS WITH MUTANT IDH1 AML
  19. 219
    “…Ivosidenib is an isocitrate dehydrogenase 1 (IDH1) inhibitor that is FDA approved for patients with IDH1 mutation and acute myeloid leukemia and previously treated locally advanced or metastatic cholangiocarcinoma. …”
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    Clinical Utility of Ivosidenib in the Treatment of IDH1-Mutant Cholangiocarcinoma: Evidence To Date
  20. 220
    por Gruber, Emily, Kats, Lev M.
    Publicado 2023
    “…Moreover, high 2-HG levels and loss of wild-type IDH1 or IDH2 activity gives rise to synthetic lethal vulnerabilities. …”
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    The curious case of IDH mutant acute myeloid leukaemia: biochemistry and therapeutic approaches
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