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  1. 2201
    “…We construct computational models of glucose and glutamine metabolism with focus on the effect of IDH1/2-mutations in cancer using a combination of experimental metabolic flux data and patient-derived gene expression data. …”
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    Probabilistic model checking of cancer metabolism
  2. 2202
    “…Combination treatments using Ventoclax and a hypomethylating agent (azacitidine or decitabine) or low-intensity chemotherapy have shown in newly diagnosed patients variable response rates, with highly responsive patients with NPM1, IDH1-IDH2, TET2, and RUNX1 mutations and with scarcely responsive patients with FLT3, TP53 and ASXL1 mutations, complex karyotypes, and secondary AMLs. …”
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    The Growing Role of the BH3 Mimetic Drug Venetoclax in the Therapy of Acute Myeloid Leukemia
  3. 2203
    “…A single-institution observational study with 43 newly diagnosed diffuse gliomas defined the isocitrate dehydrogenase 1 and 2 (IDH1/2) gene mutation status and evaluated the prognostic relevance of the methylation status of the epigenetic marker O(6)-methylguanine-DNA methyltransferase (MGMT). …”
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    The Significance of MGMT Promoter Methylation Status in Diffuse Glioma
  4. 2204
    “…This review will focus on the family of paediatric-type diffuse high-grade gliomas, which includes four tumour types: 1) Diffuse midline glioma H3 K27-altered; 2) Diffuse hemispheric glioma H3 G34-mutant; 3) Diffuse paediatric-type high-grade glioma H3-wildtype and IDH-wildtype; and 4) Infant-type hemispheric glioma. …”
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    Paediatric-type diffuse high-grade gliomas in the 5th CNS WHO Classification
  5. 2205
    “…Results: This study demonstrated: a) an improvement in the expression of IDH1 after IR and TMZ + IR in the NS (T98G); b) an increase in the expression of MGMT in NS (T98G) in IR groups and TMZ + IR. …”
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    Modulation of Genes and MicroRNAs in the Neurospheres of Glioblastoma Cell Lines U343 and T98G Induced by Ionizing Radiation and Temozolomide Therapy
  6. 2206
    “…According to the multi-variable COX model, age, extent of resection (EOR), and IDH mutation were associated with PFS and OS, while edema index (EI) was relevant to PFS. …”
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    Nomogram Model for Predicting the Prognosis of High-Grade Glioma in Adults Receiving Standard Treatment: A Retrospective Cohort Study
  7. 2207
    por Pan, Dongxiao, Fang, Xixi, Li, Jiping
    Publicado 2023
    “…Following that, systematic analyses of multi-omics data were performed to determine the differences between the two groups. In addition, IDH1 was selected for the differential expression analysis. …”
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    Identification of a Novel Gene Signature Based on Kinesin Family Members to Predict Prognosis in Glioma
  8. 2208
    “…Consistent with these results, the signature expression and release in the conditioned medium of glioma cells was lower in IDH-wild type cells compared to the mutated counterpart. …”
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    A diagnostic circulating miRNA signature as orchestrator of cell invasion via TKS4/TKS5/EFHD2 modulation in human gliomas
  9. 2209
    “…BACKGROUND: Symptomatic cervical intervertebral disc herniation (IDH) presenting as neck pain accompanied by arm pain is a common affliction whose prevalence continues to rise, and is a frequent reason for integrative inpatient care using complementary and alternative medicine (CAM) in Korea. …”
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    Long term follow-up of cervical intervertebral disc herniation inpatients treated with integrated complementary and alternative medicine: a prospective case series observational study
  10. 2210
    “…A higher LAT1 expression in IDH-mutant astrocytomas seems to be associated with a short PFS. …”
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    L-type amino acid transporter (LAT) 1 expression in (18)F-FET-negative gliomas
  11. 2211
    “…Important cancer genes affected by CNVs included TP53, BRCA1, BRCA2, ERBB2, IDH1, and IDH2. WES detected numerous mutations, some of which affecting BC associated genes as CDH1, HEPACAM, and LOXHD1. …”
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    Comprehensive molecular biomarker identification in breast cancer brain metastases
  12. 2212
    “…Considering the highly aggressive nature of MGMT(m)/IDH(wt)/non-codel tumors, for these patients, the margin could be further expanded by 0.5 cm. …”
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    Clinicopathologic analysis of microscopic tumor extension in glioma for external beam radiotherapy planning
  13. 2213
    “…The predominant mutations were in KRAS (n=17; 22.4%), TP53 (n=17; 22.4%), PIK3CA (n=7; 9.2%), FGFR2 (n=7; 9.2%), DNMT3A (n=7; 9.2%), IDH1 (n=7; 9.2%), IDH2 (n=6; 7.9%), CDKN2A (n=6; 7.9%), BAP1 (n=4; 5.3%), NF1 (n=4; 5.3%), and NF2 (n=4; 5.3%). …”
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    Austrian tricentric real-life analysis of molecular profiles of metastatic biliary tract cancer patients
  14. 2214
    “…Molecular and histopathological analysis of the resected tumor supported a diagnosis of IDH-wild type GBM. The patient’s family medical history was significant for GBM. …”
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    Glioblastoma in pregnant patient with pathologic and exogenous sex hormone exposure and family history of high-grade glioma: A case report and review of the literature
  15. 2215
    “…SIMPLE SUMMARY: Glioblastoma, IDH-wild type (GBM) is the most common malignant primary brain tumor. …”
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    Improving Localized Radiotherapy for Glioblastoma via Small Molecule Inhibition of KIF11
  16. 2216
    “…Among these cases, two patients had a conversion from the IDH mutation in the originating state to the IDH1 wild state during the process of gene evolution under chemotherapy treatment, indicating that the cell phenotype and genetic characteristics of oligodendroglioma may change during tumor evolution. …”
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    Genomic alterations of oligodendrogliomas at distant recurrence
  17. 2217
    “…We composed a 3′ RACE-based RNA sequencing panel for the analysis of FGFR1–4 gene rearrangements, detection of activating mutations located within FGFR1–4, IDH1/2, ERBB2 (HER2), KRAS, NRAS, BRAF, and PIK3CA genes, and measurement of the expression of ERBB2, PD-L1, and FGFR1–4 transcripts. …”
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    Molecular Analysis of Biliary Tract Cancers with the Custom 3′ RACE-Based NGS Panel
  18. 2218
    “…G6PDH showed the highest activity in the first, whereas, NADP-IDH showed the same activity in the last days of the experiment. …”
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    Individual and combinative effect of NaCl and γ-radiation on NADPH-generating enzymes activity in corn (Zea mays L.) sprouts
  19. 2219
    “…We conclude that VPS-HA may improve IDH in diabetic HD patients.…”
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    Improvement of Intradialytic Hypotension in Diabetic Hemodialysis Patients Using Vitamin E-Bonded Polysulfone Membrane Dialyzers
  20. 2220
    “…Pearson’s Chi square test demonstrated GBMO-STS exhibited lower 1p/19q co-deletion, IDH1 mutation rates than AOA or GBMO-LTS (P = 0.032, P = 0.045 for 1p/19q co-deletion; P = 0.034, P = 0.005 for IDH1 mutation, respectively) but higher chromosome 1q, 19p polysomy rates compared with AOA or GBM (P = 0.037, P = 0.030 for 1q polysomy; P = 0.017, P = 0.011 for 19p polysomy, respectively). …”
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    Short-term survivors in glioblastomas with oligodendroglioma component: a clinical study of 186 Chinese patients from a single institution
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