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  1. 2261
    “…This molecular information is being increasingly used to refine diagnosis, risk stratification, monitoring of residual disease and response to treatment. ASXL1, SRSF2, EZH2, IDH1/IDH2 and U2AF1 mutations are associated with a more advanced disease and reduced overall survival in primary myelofibrosis (PMF), whereas spliceosome mutations in Polycythemia vera (PV) and essential thrombocythemia (ET) adversely affect both overall (SF3B1, SRSF2 in ET and SRSF2 in PV) and myelofibrosis-free (U2AF1, SF3B1 in ET) survival. …”
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    Impact of Mutational Profile on the Management of Myeloproliferative Neoplasms: A Short Review of the Emerging Data
  2. 2262
    “…The risk score, age, grade, and IDH1 mutation were identified as independent prognostic factors in patients with LGGs. …”
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    An Immune-Related Signature for Predicting the Prognosis of Lower-Grade Gliomas
  3. 2263
    “…Compared with mutational profiling routinely analyzed using tumor samples, several additional targets with currently available therapies, including IDH1, IDH2, and PDGFRA mutations, were discovered. …”
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    Clinical Utility of a Cell-Free DNA Assay in Patients With Colorectal Cancer
  4. 2264
    “…Small molecule inhibitors targeting cellular oncoproteins and enzymes such as BCR-ABL, JAK2, Bruton tyrosine kinase, FLT3, BCL-2, IDH1, IDH2, are biomarker-driven chemotherapy-free agents approved for several major hematological malignancies. …”
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    Novel agents and regimens for hematological malignancies: recent updates from 2020 ASH annual meeting
  5. 2265
    “…SBF2-AS1 was found to be significantly related to IDH mutation status and SBF2-AS1 was highly expressed in IDH wildtype group. …”
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    Prognostic Value of Immune-Related lncRNA SBF2-AS1 in Diffuse Lower-Grade Glioma
  6. 2266
    “…Age, gender, history of smoking, tumor side, tumor grade, Ki-67 expression, and IDH1 mutation were not associated with seizure. …”
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    Seizure in Indonesian Glioma Patients: Associated Risk Factors and Impact on Survival
  7. 2267
    “…We independently validated three protein hits, Idh3b, Aifm1, and Cpt1b, as RyR2 interactors by western blots and showed that Aifm1 and Idh3b had significantly decreased binding to RyR2 S2814D compared to WT and S2814A, consistent with MS findings. …”
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    Phosphorylation-Dependent Interactome of Ryanodine Receptor Type 2 in the Heart
  8. 2268
    “…Immunohistochemistry was used to detect the expression of CD276, isocitrate dehydrogenase-1 (IDH1), matrix metallopeptidase 9 (MMP9), p53, and Ki-67, and 1p/19q co-deletion was detected by fluorescence in situ hybridization (FISH). …”
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    High expression of cluster of differentiation 276 indicates poor prognosis in glioma
  9. 2269
    “…Mutations targeting genes encoding DNA methyltransferase (DNMT), TET family of DNA demethylases, and isocitrate dehydrogenase (IDH1, IDH2) that produce TET inhibitory metabolite, 2-hyoxyglutarate (2-HG), are found in more than half of acute myeloid leukemia (AML). …”
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    CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML
  10. 2270
    “…The post-operative prognosticators were: (1) IDH-wt, (2) TP53 mutation, and (3) temozolomide monotherapy. …”
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    Systematic review—Time to malignant transformation in low-grade gliomas: Predicting a catastrophic event with clinical, neuroimaging, and molecular markers
  11. 2271
    “…Three radiogenomics-NB molecular mutation models (e.g., IDH mutation, 1p/19q codeletion, and ATRX mutation) are investigated. …”
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    Joint Modeling of RNAseq and Radiomics Data for Glioma Molecular Characterization and Prediction
  12. 2272
    “…Here, we describe the development of a CAR targeting the tumor-specific isocitrate dehydrogenase 2 (IDH2) with R140Q mutation presented on the cell surface in complex with a common human leukocyte antigen allele, HLA-B*07:02. …”
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    Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens
  13. 2273
    “…The results showed that isocitrate dehydrogenase 1 (IDH1) mutation was significantly correlated with the incidence of perioperative epilepsy. …”
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    Correlation Between Tumor Molecular Markers and Perioperative Epilepsy in Patients With Glioma: A Systematic Review and Meta-Analysis
  14. 2274
    “…The onco-metabolite 2-hydroxyglutarate (2HG), a biomarker of IDH-mutant gliomas, can be detected with (1)H MR spectroscopy ((1)H-MRS). …”
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    Comparison of 2-Hydroxyglutarate Detection With sLASER and MEGA-sLASER at 7T
  15. 2275
    “…Nine cases had glioblastomas-IDH1-wild and one case had glioblastoma-IDH1-mutant. …”
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    Caractéristiques épidémiologiques, cliniques, thérapeutiques et évolutives des patients atteints de glioblastome cérébral: série de cas pris en charge au centre d´oncohématologie du Centre Hospitalier Universitaire Mohammed VI de Marrakech en 2016 et 2017
  16. 2276
    “…When patients were stratified according to the cIMPACT-NOW update 6, subventricular zone involvement was negatively associated with outcome in IDH-wildtype astrocytomas and 1p19q-codeleted oligodendrogliomas but not in IDH-mutant astrocytomas. …”
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    Subventricular zone involvement is associated with worse outcome in glioma WHO grade 2 depending on molecular markers
  17. 2277
    “…The comprehensive results showed IDH, pentatricopeptide repeat-containing protein (PPRC), Unigene.16454, and caffeoyl-CoA O methyltransferase 5-like (CCOAOMT) are the top-ranked stable genes across all the samples. …”
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    Validation of Reference Genes for Quantitative Real-Time PCR Normalization in Ananas comosus var. bracteatus During Chimeric Leaf Development and Response to Hormone Stimuli
  18. 2278
    “…Moreover, we observed high frequencies of mutations in RUNX1, SRSF2, IDH2, NRAS, and EZH2 in cases comprising at least 1 DTA (DNMT3A, TET2, ASXL1) mutation, whereas in cases without DTA mutations, TP53, KRAS, WT1, and SF3B1 were more frequent across entities, suggesting differences in pathophysiology. …”
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    Mutational patterns and their correlation to CHIP-related mutations and age in hematological malignancies
  19. 2279
    “…The ultrasound semantic features were correlated with histological features like tumor grade, IDH status, and MIB index. Results 68 patients were analyzed using the semantic proforma. …”
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    Development of a Standardized Semantic Feature-Based Reporting Proforma for Intraoperative Ultrasound Findings in Brain Tumors and Application in High-Grade Gliomas – A Preliminary Study
  20. 2280
    “…High GSDMD expression was significantly associated with WHO grade IV, IDH 1/2 wild-type, mesenchymal subtypes and shorter overall survival.Moreover, GSDMD expression increased with after treating with TMZ in a time-dependent manner. …”
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    Gasdermin D Is a Novel Prognostic Biomarker and Relates to TMZ Response in Glioblastoma
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