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Mostrando 221 - 240 Resultados de 4,168 Para Buscar '"IDH"', tiempo de consulta: 0.29s Limitar resultados
  1. 221
    por Bao, Jing, Pan, Zhenjiang, Wei, Shepeng
    Publicado 2023
    “…Initial management involves maximising surgical resection while preserving neurologic function. IDH mutations and MGMT promoter methylation should be checked in tumour samples. …”
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    Initial Treatment of IDH-Wildtype Glioblastoma in Adults Older Than 70 Years
  2. 222
    “…IDH1 mutations frequently occur early in human glioma. …”
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    IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma
  3. 223
    “…In this project, we analyzed matched IDH-mutant astrocytomas before and after progression to grade 4 from six patients (discovery cohort) with genome-wide sequencing, 21 additional patients with targeted sequencing, and 33 patients from Glioma Longitudinal AnalySiS cohort for validation. …”
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    Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting
  4. 224
    “…Mutations in isocitrate dehydrogenase 1 and 2 (IDH1, 2) have been demonstrated in the majority of World Health Organization grade 2 and grade 3 gliomas in adults. …”
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    2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated glioma patients
  5. 225
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    Metabolic alterations due to IDH1 mutation in glioma: opening for therapeutic opportunities?
  6. 226
    por Van Noorden, Cornelis JF
    Publicado 2014
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    The NADP(+)-dependent IDH1 mutation and its relevance for glioblastoma patient survival
  7. 227
    por Chu, Bo, Wu, Ting, Miao, Lin, Mei, Yide, Wu, Mian
    Publicado 2015
    “…MiR-181a is able to target isocitrate dehydrogenase 1 (IDH1), a metabolic enzyme in TCA cycle. Via targeting IDH1, miR-181a decreases expression of genes involved in lipid synthesis and increases expression of genes involved in β-oxidation, thereafter inhibiting lipid accumulation. …”
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    MiR-181a regulates lipid metabolism via IDH1
  8. 228
    “…Clinical parameters were obtained from medical records. Mutations of IDH1/2 were analyzed in these patients, by immunohistochemistry for the R132H mutation of IDH1 and by high-resolution melting-curve analysis, followed by Sanger sequencing for IDH1 and IDH2 exon 4 mutations. …”
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    IDH-Mutation Is a Weak Predictor of Long-Term Survival in Glioblastoma Patients
  9. 229
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    IDH mutation-induced suppression of type-1 anti-glioma immune response
  10. 230
    “…BACKGROUND: The relative contribution of isocitrate dehydrogenase mutations (mIDH) and O6-methylguanine-DNA methyltransferase promoter methylation (methMGMT) as biomarkers in glioblastoma remain poorly understood. …”
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    IDH mutation and MGMT promoter methylation in glioblastoma: results of a prospective registry
  11. 231
    “…Randomized controlled trials, and prospective and retrospective studies of patients with glioblastomas that provided IDH mutation and survival data were included. OS and PFS were used to evaluate the association of IDH1 and IDH1/2 mutations and prognosis. …”
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    Isocitrate Dehydrogenase (IDH)1/2 Mutations as Prognostic Markers in Patients With Glioblastomas
  12. 232
    “…Up to 90% of grades II-III gliomas contain a single mutant isocitrate dehydrogenase 1 (IDH1) allele. IDH1 mutant-mediated transformation is associated with TMZ resistance; however, there is no clinically available means of sensitizing IDH1 mutant tumors to TMZ. …”
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    PLK1 inhibition enhances temozolomide efficacy in IDH1 mutant gliomas
  13. 233
    “…Leveraging the multi-platform data, we observed that ARID1A exhibited DNA hypermethylation and decreased expression in the IDH mutant subtype. More broadly, we found that IDH mutations are associated with an expanded histological spectrum of liver tumors with molecular features that stratify with CCA. …”
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    Integrative Genomic Analysis of Cholangiocarcinoma Identifies Distinct IDH-Mutant Molecular Profiles
  14. 234
    “…NLRs, PLRs, and LMRs were calculated before surgery. IDH mutations were detected immunohistochemically after tumor resection, and patients' clinical outcomes were analyzed after classification into GBM, pGBM, and IDH-wild type glioblastoma (IDH-wt GBM) groups. …”
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    Preoperative inflammation markers and IDH mutation status predict glioblastoma patient survival
  15. 235
    “…Isocitrate dehydrogenase (IDH) 2 participates in the TCA cycle and catalyzes the conversion of isocitrate to α-ketoglutarate and NADP(+) to NADPH. …”
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    Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice
  16. 236
    “…The role of isocitrate dehydrogenase 1 (IDH1) mutation in brain stem glioma is not clear. …”
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    IDH1 Mutation in Brain Stem Glioma: Case Report and Review of Literature
  17. 237
    “…IDH2 deficiency also promoted pigmentation on the dorsal skin of mice, as evident from the elevated levels of melanin synthesis markers. …”
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    IDH2 deficiency accelerates skin pigmentation in mice via enhancing melanogenesis
  18. 238
    “…Molecular studies demonstrated the presence of IDH1 IDH1 c.395G>A p.R132H and CIC c.601C>T p.R281W mutations and 1p/19q codeletion. …”
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    Primary Leptomeningeal Oligodendroglioma, IDH-Mutant, 1p/19q-Codeleted
  19. 239
    “…Enasidenib (AG-221) is an allosteric inhibitor that binds to the IDH2 dimer interface and blocks 2HG production by IDH2 mutants(9,10). …”
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    Acquired resistance to IDH inhibition through trans or cis dimer-interface mutations
  20. 240
    “…Due to the paucity of cell models of Isocitrate Dehydrogenase 1 mutant (IDH1(mut)) GSCs, biology under hypoxic conditions has not been sufficiently studied as compared to IDH1 wildtype (IDH1(wt)) GSCs. …”
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    Identification of a Prognostic Hypoxia-Associated Gene Set in IDH-Mutant Glioma
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