“…Potential ALK‐I‐resistance mutations were also found in PIK3CA and IDH2. Finally, a c‐MYC gain, along with a loss of CCND1 and FGFR3, was detected in a patient progressing on a first‐line treatment with crizotinib. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CCT6A protein expression was correlated with increased World Health Organization (WHO) grade (P < 0.001) and less isocitrate dehydrogenase (IDH) mutation (P = 0.002); meanwhile, CCT6A mRNA expression was only related to elevated WHO grade (P = 0.001). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Immunogenic cell death regulators and immune checkpoints were also diversely expressed in the four immune subtypes. CONCLUSION: TP53, IDH1, C3, and TCF12 are effective antigens for the development of anti-glioma mRNA vaccines. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Meanwhile, the expression of proteins associated with synthesis and degradation of ketone bodies, butanoate metabolism, and citrate cycle signaling transduction pathway were upregulated in the group with starter diet supplementation, including 3-hydroxy-3-methylglutaryl coenzyme A synthase (HMGCS2, fold change [FC] = 1.93), 3-hydroxybutyrate dehydrogenase 1 (BDH1, FC = 1.91), and isocitrate dehydrogenase 1 (IDH1, FC = 8.12). The metabolic processes associated with ammonia detoxification and antioxidant stress were also affected by starter diet supplementation, with proteins, microsomal glutathione S-transferase 3 (MGST3, FC = 2.37) and IDH1, linked to the biosynthesis of glutamate and glutathione metabolism pathway being upregulated in the group with starter diet supplementation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, the detection of NSCLC with rarely arising mutations of the isocitrate dehydrogenase (IDH) gene was demonstrated through 45 times enhanced oncometabolite levels. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Patients with Astrocytoma, IDH mutant LrGGs were more likely to show lower cognitive performance than patients with Oligodendroglioma, IDH mutant 1p19q co-deleted LrGGs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Results: The cohort included eight pilocytic astrocytomas, one oligodendroglioma, six IDH(wildtype) glioblastomas, four IDH(mutant) grade four astrocytomas, and one sample of each (astroblastoma, central neurocytoma, medulloblastoma, and liponeurocytoma). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The investigated ddPCR-based assays enable the detection of diagnostically relevant glioma-associated mutations in the IDH1, IDH2, H3-3A, BRAF, and PRKCA genes, as well as in the TERT promoter. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Genes such as FRZB, ASPN, and PHLDA1 were significantly upregulated, whereas IDH2 and ENDOG were significantly downregulated. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Noteworthily, demethylation-inhibiting IDH1 mutation increases the DNA 6mA content in human gliomas, but the depletion of the demethylase candidate ALKBH1 fails to do so, together suggesting the presence of other unknown 6mA demethylase for erasing misincorporated DNA 6mA. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Other markers, including IDH1, BRAF VE1, Olig-2, and EMA, were negative. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Its projection of survival can be equally estimated before and after surgery. IDH-mutation caused longer survival and higher functionality.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Results: All GBMs were wild-type IDH, with a subgroup of classical GBMs according to the EGFR amplification (44%). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Twelve (17.9%) clinical trials dealt with isocitrate dehydrogenase (IDH) 1/2 targeting therapy either in combination with cisplatin (Cis) and gemcitabine (Gem) as first-line treatment for BTCs or in monotherapy in patients with IDH1 mutant advanced malignancies, including cholangiocarcinoma (CCA). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CBX2/6/7 were positively correlated with IDH mutation and CBX1/2/4/5/8 were closely related to GBM subtypes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In groups with high-CuproptosisScore, PIK3CA, MUC16, NF1, TTN, TP53, PTEN, and EGFR showed high mutation frequency. IDH1, TP53, ATRX, CIC, and FUBP1 demonstrated high mutation frequency in low-CuproptosisScore group. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The NGS panel included eight genes CCND1, DIS3, EGR1, FAM46C (TENT5C), FGFR3, PRDM1, TP53, TRAF3, and seven hotspots in BRAF, IDH1, IDH2, IRF4, KRAS, NRAS. RESULTS: Mutations were detected in 64/90 (71%) of cases. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, single-cell sequencing analyses further demonstrated a polyclonal pattern was present at either MDS or AML stages, whereas IDH2 mutated cell clones appeared only at the leukemia stage. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Predictive factors for response to regorafenib in recurrent glioblastoma, IDH-wildtype, are scarcely recognized. The objective of this study was to identify molecular predictive factors for response to regorafenib using a clinically available platform. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Compared with traditional clinicopathological features [age, sex, grade, isocitrate dehydrogenase (IDH) status], the prognostic accuracy of this model is more stable and stronger. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso