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  1. 2541
    “…Previous studies reported poor outcome, likely due to the inclusion of isocitrate dehydrogenase (IDH) wildtype astrocytomas and advocated defensive surgical and adjuvant treatment. …”
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    Isocitrate-dehydrogenase-mutant lower grade glioma in elderly patients: treatment and outcome in a molecularly characterized contemporary cohort
  2. 2542
    “…New therapeutic pathways for the treatment of this tumor type are still being identified with new emerging potential targets such as isocitrate dehydrogenase (IDH), fibroblast growth factor receptor 2 (FGFR2), or BRAF mutation.…”
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    New Options for Systemic Therapies in Intrahepatic Cholangiocarcinoma (iCCA)
  3. 2543
    “…. • Glioblastomas arising from MCT-MT appear to exhibit wild type IDH gene status. • Advanced-stage glioblastoma arising from MCT-MT exhibits aggressive behavior and requires adjuvant therapy. • Optimal adjuvant therapy regimen for glioblastoma arising from MCT-MT remains unknown.…”
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    Secondary somatic glioblastoma arising from a mature ovarian cystic teratoma in a patient with underlying Li-Fraumeni syndrome
  4. 2544
    por Takahashi, Shinichiro
    Publicado 2011
    “…The aim of this review is to summarize the current findings for the identification of these gene mutations (Dnmt, TET2, IDH1/2, NPM1, ASXL1, etc.), most of which are frequently found in cytogenetically normal AML. …”
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    Current findings for recurring mutations in acute myeloid leukemia
  5. 2545
    “…Novel “genome-wide” techniques have identified additional important molecular alterations as mutations in isocitrate dehydrogenase 1 (IDH1) and its prognostic importance. This review summarizes findings and techniques of genetic, epigenetic, transcriptional, and proteomic studies of glioblastoma. …”
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    Recent advances in the molecular understanding of glioblastoma
  6. 2546
    “…Immunohistochemical analyses demonstrated that the tumor cells were immunopositive for epidermal growth factor receptor and immunonegative for p53 mutation and IDH1 R132H, indicating that it had different genetic features from a typical cerebellar glioblastoma. …”
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    Exophytic Cerebellar Glioblastoma in the Cerebellopontine Angle: Case Report and Review of the Literature
  7. 2547
    “…Recent sequencing studies have clarified the recurrent mutations in ras homology family member A (RHOA) and in genes encoding epigenetic regulators, tet methyl cytosine dioxygenase 2 (TET2), DNA methyl transferase 3 alpha (DNMT3A) and isocitrate dehydrogenase 2, mitochondrial (IDH2), as well as those related to the T‐cell receptor signaling pathway in AITL. …”
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    Review of the biologic and clinical significance of genetic mutations in angioimmunoblastic T‐cell lymphoma
  8. 2548
    “…Further study into the association between AMPA signaling, IDH1 status and seizures is warranted.…”
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    Adjunctive perampanel for glioma-associated epilepsy()
  9. 2549
    por Naoe, Tomoki
    Publicado 2020
    “…Recently, drugs targeted to Bcl-2, SMO, FLT3, and IDH1/2 have been shown to prolong overall survival alone or in combination with reduced-intensity chemotherapy. …”
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    ＜Editors’ Choice＞ How to improve outcomes of elderly patients with acute myeloid leukemia: era of excitement
  10. 2550
    por Millar, Beverley C., Moore, John E.
    Publicado 2021
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    Re-purposing of domestic steam disinfectors within the Hospital-at-Home setting: Reconciliation of steam disinfector thermal performance against SARS- CoV-2 (COVID-19), norovirus and other viruses’ thermal susceptibilities
  11. 2551
    “…Genes such as DNA methyltransferase 3A (DNMT3A), ten eleven translocation methylcytosine dioxygenase 2 (TET2), additional sex combs-like 1 (ASXL1), enhancer of zeste homolog 2 (EZH2) and isocitrate dehydrogenase 1/2 (IDH1/2) show functional impact in disease pathogenesis. …”
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    The Impact of Epigenetic Modifications in Myeloid Malignancies
  12. 2552
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    Universal testing for SARS-CoV-2 infection on admission among hospitalized emergency patients: A survey report from a single facility in Tokyo
  13. 2553
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    A hospital-wide response to multiple outbreaks of COVID-19 in health care workers: Lessons learned from the field
  14. 2554
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    Use of portable air cleaners to reduce aerosol transmission on a hospital COVID-19 ward
  15. 2555
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    Emergency care practitioners’ knowledge, preparedness and experiences of managing COVID-19 in Australia
  16. 2556
    “…In this review, we discuss the development of promising new molecular targeted approaches for AML, including menin inhibition, novel IDH1/2 inhibitors, and preclinical means to target TET2, ASXL1, and RNA splicing factor mutations. …”
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    Translating recent advances in the pathogenesis of acute myeloid leukemia to the clinic
  17. 2557
    “…She was found to have a 3 cm right-sided ring-enhancing lesion that was excised and found to be a grade IV Isocitrate dehydrogenase (IDH) wildtype GB.…”
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    Schwannomatosis Presenting With a Grade IV Glioblastoma: A Case Report and Literature Review
  18. 2558
    “…The standard of care for isocitrate dehydrogenase (IDH)-wildtype glioblastoma (GBM) is maximal resection followed by chemotherapy and radiation. …”
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    FLAIRectomy: Resecting beyond the Contrast Margin for Glioblastoma
  19. 2559
    por Alturkustani, Murad
    Publicado 2022
    “…Gliosarcoma is a rare subtype of glioblastoma, isocitrate dehydrogenase (IDH) wildtype. This biphasic tumor has two components. …”
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    Gliosarcoma With Glioneuronal and Rhabdomyosarcoma Components
  20. 2560
    “…CONCLUSION: Monitoring of patients on oral anticoagulants helps prevent the occurrence of IDH and avoid its complications, which can be fatal.…”
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    Acute pancreatitis secondary to spontaneous intramural duodenal hematoma: A case report and a review of the literature()
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