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2561
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2562por Hor, Su-yin, Burns, Penelope, Yong, Faith, Barratt, Ruth, Degeling, Chris, Williams Veazey, Leah, Wyer, Mary, Gilbert, LynEnlace del recurso
Publicado 2022
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2563“…Hypomethylating agents (HMAs) have been used for decades in the treatment of hematologic neoplasms, and now, have gathered attention again in terms of their combination with potent molecular-targeted agents such as a BCL-6 inhibitor venetoclax and an IDH1 inhibitor ivosidenib, as well as a novel immune-checkpoint inhibitor (anit-CD47 antibody) megrolimab. …”
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2564por Demetz, Matthias, Krigers, Aleksandrs, Moser, Patrizia, Kerschbaumer, Johannes, Thomé, Claudius, Freyschlag, Christian F.“…Clinical and routine neuropathological data were gained from patients’ charts. If IDH1, ATRX and EGFR were not routinely assessed, they were re-determined. …”
Publicado 2023
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2565por Fu, Minjie, Zhou, Zhirui, Huang, Xiao, Chen, Zhenchao, Zhang, Licheng, Zhang, Jinsen, Hua, Wei, Mao, Ying“…Specific molecular alterations (IDH mutation status) and clinical features (large tumor burden and double-positive sign) could predict better responses to BEV administration. …”
Publicado 2023
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2566por Leske, Henning, Camenisch Gross, Ulrike, Hofer, Silvia, Neidert, Marian Christoph, Leske, Sabine, Weller, Michael, Lehnick, Dirk, Rushing, Elisabeth Jane“…Our data confirm previously published prognostic factors in IDH-wildtype glioblastoma patients, including age and temozolomide treatment as well as the global MGMT methylation status. …”
Publicado 2023
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2567por Lu, Zhaomei, He, Sheng, Kashif, Muhammad, Zhang, Zufan, Mo, Shuming, Su, Guijiao, Du, Linfang, Jiang, Chengjian“…Transcriptome data showed that the expression levels of amt, gltB, gltD, ackA and idh were downregulated, while gdhA and fdhD were upregulated. …”
Publicado 2023
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2568por Landi, Alessia, Vermeire, Jolien, Iannucci, Veronica, Vanderstraeten, Hanne, Naessens, Evelien, Bentahir, Mostafa, Verhasselt, Bruno“…Moreover, EPS15, DNM3, IDH3G and ATP6AP1 knock-down significantly decreases HIV-1 replication in T cells. …”
Publicado 2014
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2569por Jaber, Mohammed, Wölfer, Johannes, Ewelt, Christian, Holling, Markus, Hasselblatt, Martin, Niederstadt, Thomas, Zoubi, Tarek, Weckesser, Matthias, Stummer, Walter“…Fluorescence correlated with WHO grade (P < .001) and Ki-67/MIB-1 index (P < .001), but not with MGMT promoter methylation status, IDH1 mutation status, or 1p19q co-deletion status. …”
Publicado 2015
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2570por O’Brien, Timothy D., Jia, Peilin, Caporaso, Neil E., Landi, Maria Teresa, Zhao, Zhongming“…Only five genes (CHRNA5, IDH3A, PSMA4, RP11-650 L12.2, and TBC1D2B) overlapped all subtypes. …”
Publicado 2018
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2571por Vomacka, Lena, Unterrainer, Marcus, Holzgreve, Adrien, Mille, Erik, Gosewisch, Astrid, Brosch, Julia, Ziegler, Sibylle, Suchorska, Bogdana, Kreth, Friedrich-Wilhelm, Tonn, Jörg-Christian, Bartenstein, Peter, Albert, Nathalie Lisa, Böning, Guido“…We found significant differences of the parameters between WHO grades and IDH mutation status, where the effect size was predominantly higher for voxel-based PVHs compared to the corresponding VOI-based parameters. …”
Publicado 2018
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2572por Liu, Yongming, Wei, Gui, Xia, Yuanyan, Liu, Xiaowei, Tang, Jin, Lu, Yanli, Lan, Hai, Zhang, Suzhi, Li, Chuan, Cao, Moju“…The results of our subsequent enzyme-linked immunosorbent assay (ELISA) experiments pointed out that the contents of both the IDH and OGDH enzymes accumulated more in the spikelets of NIL_Rf4 than in those of NIL_rf4. …”
Publicado 2018
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2573por Williams, Patrick, Basu, Sreyashi, Garcia‐Manero, Guillermo, Hourigan, Christopher S., Oetjen, Karolyn A., Cortes, Jorge E., Ravandi, Farhad, Jabbour, Elias J., Al‐Hamal, Zainab, Konopleva, Marina, Ning, Jing, Xiao, Lianchun, Hidalgo Lopez, Juliana, Kornblau, Steve M., Andreeff, Michael, Flores, Wilmer, Bueso‐Ramos, Carlos, Blando, Jorge, Galera, Pallavi, Calvo, Katherine R., Al‐Atrash, Gheath, Allison, James P., Kantarjian, Hagop M., Sharma, Padmanee, Daver, Naval G.“…Expression of these markers was correlated with patient age, karyotype, baseline next‐generation sequencing for 28 myeloid‐associated genes (including P53), and DNA methylation proteins (DNA methyltransferase 3α, isocitrate dehydrogenase 1[IDH1], IDH2, Tet methylcytosine dioxygenase 2 [TET2], and Fms‐related tyrosine kinase 3 [FLT3]). …”
Publicado 2018
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2574por Binder, H., Willscher, E., Loeffler-Wirth, H., Hopp, L., Jones, D. T. W., Pfister, S. M., Kreuz, M., Gramatzki, D., Fortenbacher, E., Hentschel, B., Tatagiba, M., Herrlinger, U., Vatter, H., Matschke, J., Westphal, M., Krex, D., Schackert, G., Tonn, J. C., Schlegel, U., Steiger, H.-J., Wick, W., Weber, R. G., Weller, M., Loeffler, M.“…We found analogies between astrocytoma-like LGG with grade IV IDH-wild type tumors regarding possible worsening of treatment resistance along a proneural-to-mesenchymal axis. …”
Publicado 2019
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2575“…Isolated diastolic hypertension (IDH) was defined as DBP ≥80 mmHg and SBP <130 mmHg, isolated systolic hypertension (ISH) as SBP ≥130 mmHg and DBP <80 mmHg, and systolic diastolic hypertension (SDH) as SBP ≥130 mmHg and DBP ≥80 mmHg. …”
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2576por Zeng, Ying, Zhu, Xiangfeng, Wang, Yali, Liu, Bo, Yang, Xin, Wang, Qiushi, Du, Juan, Ma, Yu, Lin, Li, Fu, Ping, Xiao, Hualiang, Guo, Qiao-Nan“…A 1p/19q analysis via FISH, MGMT promoter methylation by MS-PCR, and IDH1 and BRAF V600E mutation analysis by HRM-PCR were performed. …”
Publicado 2020
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2577por Hsu, Justin Bo-Kai, Chang, Tzu-Hao, Lee, Gilbert Aaron, Lee, Tzong-Yi, Chen, Cheng-Yu“…In both the GBM and LGG cohort study, most of the patients in the high-risk group had the IDH1 wild-type gene, and those in the low-risk group had IDH1 mutations. …”
Publicado 2019
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2578por Lebrun, Laetitia, Meléndez, Barbara, Blanchard, Oriane, De Nève, Nancy, Van Campenhout, Claude, Lelotte, Julie, Balériaux, Danielle, Riva, Matteo, Brotchi, Jacques, Bruneau, Michaël, De Witte, Olivier, Decaestecker, Christine, D’Haene, Nicky, Salmon, Isabelle“…As in the brain, grade I pilocytic IMAs frequently harbored KIAA1549-BRAF fusions but with different fusion types. Non-canonical IDH mutations were observed in only 2 grade II diffuse IMAs. …”
Publicado 2020
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2579por Golebiewska, Anna, Hau, Ann-Christin, Oudin, Anaïs, Stieber, Daniel, Yabo, Yahaya A., Baus, Virginie, Barthelemy, Vanessa, Klein, Eliane, Bougnaud, Sébastien, Keunen, Olivier, Wantz, May, Michelucci, Alessandro, Neirinckx, Virginie, Muller, Arnaud, Kaoma, Tony, Nazarov, Petr V., Azuaje, Francisco, De Falco, Alfonso, Flies, Ben, Richart, Lorraine, Poovathingal, Suresh, Arns, Thais, Grzyb, Kamil, Mock, Andreas, Herold-Mende, Christel, Steino, Anne, Brown, Dennis, May, Patrick, Miletic, Hrvoje, Malta, Tathiane M., Noushmehr, Houtan, Kwon, Yong-Jun, Jahn, Winnie, Klink, Barbara, Tanner, Georgette, Stead, Lucy F., Mittelbronn, Michel, Skupin, Alexander, Hertel, Frank, Bjerkvig, Rolf, Niclou, Simone P.“…We report the establishment a large cohort of unique organoids and patient-derived orthotopic xenografts (PDOX) of various glioma subtypes, including gliomas with mutations in IDH1, and paired longitudinal PDOX from primary and recurrent tumors of the same patient. …”
Publicado 2020
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2580por Ross, Jeffrey S., Sokol, Ethan S., Moch, Holger, Mileshkin, Linda, Baciarello, Giulia, Losa, Ferran, Beringer, Andreas, Thomas, Marlene, Elvin, Julia A., Ngo, Nhu, Jin, Dexter X., Krämer, Alwin“…Key genomic alterations included ERBB2 (7.3%), PIK3CA (6.3%), NF1 (5.6%), NF2 (4.6%), BRAF (4.3%), IDH1 (3.3%), PTEN, FGFR2, EGFR (3.6% each), MET (4.3%), CDK6 (3.0%), FBXW7, CDK4 (2.3% each), IDH2, RET, ROS1, NTRK (1.0% each), and ALK (0.7%). …”
Publicado 2020
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