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  1. 2621
    “…Well-characterised entities (n=50, including IDH-mutant tumours (n=18), PXA (n=12)) were excluded. …”
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    HGG-15. HIGH-GRADE GLIOMAS OCCURRING IN TEENAGERS AND YOUNG ADULT PATIENTS COMPRISE NOVEL MOLECULAR SUBGROUPS
  2. 2622
    “…BACKGROUND: Glioma grade 4 (GG4) tumors, including astrocytoma IDH-mutant grade 4 and the astrocytoma IDH wt are the most common and aggressive primary tumors of the central nervous system. …”
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    Machine learning to improve interpretability of clinical, radiological and panel-based genomic data of glioma grade 4 patients undergoing surgical resection
  3. 2623
    “…In conclusion, our study improves the understanding of TSPO as an imaging marker in gliomas by unveiling IDH-dependent differences in TSPO expression/regulation, regional heterogeneity of the TSPO PET signal and functional implications of TSPO in terms of tumor immune cell interactions. …”
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    Translocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages
  4. 2624
    “…AIM: In patients with isocitrate dehydrogenase (IDH) mutated anaplastic glioma determine the dosimetric benefits of delivering radiation therapy using a PET guided integrated boost IMRT technique (ib-IMRT) compared with standard IMRT (s-IMRT) in reducing dose to normal brain. …”
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    Reducing radiation dose to normal brain through a risk adapted dose reduction protocol for patients with favourable subtype anaplastic glioma
  5. 2625
    “…Here, we characterized the landscapes of mutations in H3 K27M, isocitrate dehydrogenase 1 (IDH1) R132H, BRAF V600E, and the TERT promoter in 83 diffuse spinal cord astrocytic tumors. …”
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    The molecular characteristics of spinal cord gliomas with or without H3 K27M mutation
  6. 2626
    “…In contrast, in lower-grade astrocytoma, mainly in those harboring the IDH1 mutation, the gene expression profile indicates that tumor cells might be sensitized to oxidative stress due to reduced GSH synthesis. …”
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    Glutaminolysis dynamics during astrocytoma progression correlates with tumor aggressiveness
  7. 2627
    “…RESULTS: (18)F-FET PET sensitivity, specificity, positive predictive value, negative predictive value were 86.2, 81.3, 89.3, 76.5%, respectively; higher diagnostic accuracy was yielded in IDH-wild-type glioma patients compared to IDH-mutant glioma patients (sensitivity: 81.8 versus 88.9%; specificity: 80.8 versus 81.8%). …”
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    Diagnostic and Prognostic Potential of (18)F-FET PET in the Differential Diagnosis of Glioma Recurrence and Treatment-Induced Changes After Chemoradiation Therapy
  8. 2628
    “…The impacts of TRPM7 silencing on the levels of glycolysis-related HK2, PDK1 and oxidative phosphorylation (OXPHOS)-related IDH3B and UQCRC1, HIF-1α expression and AMPK phosphorylation were determined in ovarian cancer. …”
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    TRPM7 silencing modulates glucose metabolic reprogramming to inhibit the growth of ovarian cancer by enhancing AMPK activation to promote HIF-1α degradation
  9. 2629
    “…Clinical characteristics and information on IDH and MGMT promoter methylation status were collected. …”
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    CXCR4 expression in glioblastoma tissue and the potential for PET imaging and treatment with [(68)Ga]Ga-Pentixafor /[(177)Lu]Lu-Pentixather
  10. 2630
    “…No significant correlation of IDH, IFD, JOA, NDI or aVAS with nVAS score was found. …”
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    Intervertebral-spreader-assisted anterior cervical discectomy and fusion prevents postoperative axial pain by alleviating facet joint pressure
  11. 2631
    “…RESULTS: Prediction rates were obtained on 2 test datasets: 69.86% for 1p/19q codeletion status on US dataset and 79.50% for IDH mutation/wild-type on TCGA dataset. Comparisons with that of using annotated GT tumor data for training showed an average of 3.0% degradation (2.92% for 1p/19q codeletion status and 3.23% for IDH genotype). …”
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    Prediction of glioma-subtypes: comparison of performance on a DL classifier using bounding box areas versus annotated tumors
  12. 2632
    “…We found that most G-I-CC are IDH-wildtype grade-4 glioblastomas involving the corpus callosum genu and with bilateral lobe infiltration. …”
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    Gliomas Infiltrating the Corpus Callosum: A Systematic Review of the Literature
  13. 2633
    “…Further, the optimized strain C. glutamicum ΔramB Δgdh IDH(R453C) (pEKEx2-malEcad(opt)), produced 3.38 ± 0.28 g itaconic acid L(−1) at 25 °C from an acetate-containing aqueous side-stream of fast pyrolysis. …”
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    Metabolic engineering of Corynebacterium glutamicum for acetate-based itaconic acid production
  14. 2634
    “…Moreover, high-risk scores were associated with wild-type IDH1, wild-type ATRX, and 1P/19Q non-co-deletion. …”
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    Interferon gamma-related gene signature based on anti-tumor immunity predicts glioma patient prognosis
  15. 2635
    “…We found that MMR gene mutations occurred in the late stage in IDH-mutant glioma during gene evolution, which activates multiple signaling pathways and significantly increases distant recurrence potential. …”
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    Molecular and clonal evolution in vivo reveal a common pathway of distant relapse gliomas
  16. 2636
    “…Immunohistochemistry and bi-directional Sanger sequencing for IDH2 mutation were used for diagnosis. Tall cell carcinoma with reverse polarity is a rare and newly described entity with characteristic morphological and molecular findings, which carries an excellent prognosis.…”
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    Tall Cell Carcinoma with Reverse Polarity of Breast: Report of a Case with Unique Morphologic and Molecular Features
  17. 2637
    “…Targets of interest in CCA include mutated isocitrate dehydrogenase-1 (mIDH-1), human epidermal growth factor receptor 2 (HER2) overexpression/amplification, and fibroblast growth factor receptor 2 (FGFR2) fusion, in addition to less frequently observed targets such as BRAF V600E, deficient mismatch repair/high microsatellite instability (dMMR/MSI-H), and high tumor mutation burden (TMB-H). …”
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    Targeted Therapies in Advanced Cholangiocarcinoma
  18. 2638
    “…We review the standard of care treatment options including combination venetoclax and hypomethylating agents, in addition to targeted therapies such as FLT3 and IDH inhibitors. Lastly, we shed light on challenges facing the care of older adults and their representation in clinical trials.…”
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    Treatment of Acute Myeloid Leukemia in Older Adults
  19. 2639
    “…The proportion of polymorphic loci was low (only 5.26% for the locus Idh). The low frequency of heterozygosity for both populations revealed a high fixation of alleles for each locus. …”
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    Allozyme differentiation of two populations of the genus Neoplecostomus Eigenmann & Eigenmann, 1888 (Teleostei, Loricariidae) from the upper Paraná River basin, Brazil
  20. 2640
    “…Examples include mutations in genes encoding proteins that modify chromatin structure (EZH2, ASXL1, IDH1/2, JAK2V617F, and IKZF1) as well as epigenetic modification of genes critical for cell proliferation and survival (suppressors of cytokine signaling, polycythemia rubra vera-1, CXC chemokine receptor 4, and histone deacetylase (HDAC)). …”
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    Epigenetic abnormalities in myeloproliferative neoplasms: a target for novel therapeutic strategies
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