Materias dentro de su búsqueda.
Mostrando 261 - 280 Resultados de 4,168 Para Buscar '"IDH"', tiempo de consulta: 0.13s Limitar resultados
  1. 261
    “…Isocitrate dehydrogenase (IDH1) catalyzes the reversible NADP(+)-dependent oxidation of isocitrate to α-ketoglutarate (αKG). …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics
  2. 262
    “…Isocitrate dehydrogenase 1 (IDH1) is a key enzyme involved in glucose metabolism that mediates the malignant transformation of tumors. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Exosomal IDH1 increases the resistance of colorectal cancer cells to 5-Fluorouracil
  3. 263
    por Voisin, Mathew, Zadeh, Gelareh
    Publicado 2021
    “…BACKGROUND: IDH mutation is the main factor used in the prognostication of diffuse gliomas, however within IDH mutated gliomas there still remains a high variability in both tumor progression and overall survival.(1) Digital droplet polymerase chain reaction (ddPCR) is one of the latest molecular amplification techniques that offers high precision in addition to the ability of absolute quantification of mutant allele copies.(2) METHODS: A total of 102 IDH mutant diffuse glioma tumor samples ranging from WHO grade 2 to 4 were collected. …”
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    NGMA-1. Quantification of IDH mutant alleles predicts outcome in diffuse gliomas
  4. 264
    “…INTRODUCTION: IDH1/2 mutations are prevalent in cartilaginous tumors including chondrosarcoma. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Prognostic importance of IDH mutations in chondrosarcoma: An individual patient data meta‐analysis
  5. 265
    “…Mutant isocitrate dehydrogenase 1/2 (mIDH1/2) gain a novel function for the conversion of α-ketoglutarate (α-KG) to oncometabolite R-2-hydroxyglutarate (R-2-HG). …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Synthetic lethality and synergetic effect: the effective strategies for therapy of IDH-mutated cancers
  6. 266
    “…In the present study, we report one case of carotid body PGL with a somatic mutation in the gene encoding isocitrate dehydrogenase 2 (IDH2). The missense mutation in IDH2 resulted in R172G amino acid substitution, which exhibits neomorphic activity and production of D-2-hydroxyglutarate.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Identification of Isocitrate Dehydrogenase 2 (IDH2) Mutation in Carotid Body Paraganglioma
  7. 267
    “…BACKGROUND: IDH-wild-type glioblastoma (GBM) is the most frequent brain-derived malignancy. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    The Prognostic Value of NANO Scale Assessment in IDH-Wild-Type Glioblastoma Patients
  8. 268
    “…Recently, small-molecule inhibitors of mutant IDH1/2 have been Food and Drug Administration–approved for the treatment of IDH1/2-mutated acute myeloid leukemia. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    IDH1/2 Mutations in Cancer Stem Cells and Their Implications for Differentiation Therapy
  9. 269
    “…The discovery of the oncometabolite 2-hydroxyglutarate in isocitrate dehydrogenase 1–mutated (IDH1-mutated) tumor entities affirmed the role of metabolism in cancer. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Tissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment
  10. 270
    “…Herein, we use global methylation profiling to evaluate a reference cohort of IDH-mutant astrocytomas with and without prior evidence of CIN (n = 42), and apply the resulting methylation-based characteristics to a larger test cohort of publicly-available IDH-mutant astrocytomas (n = 245). …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Global DNA methylation profiling reveals chromosomal instability in IDH-mutant astrocytomas
  11. 271
    “…Recurrent mutations in IDH1 or IDH2 in acute myeloid leukemia (AML) are associated with increased DNA methylation, but the genome-wide patterns of this hypermethylation phenotype have not been comprehensively studied in AML samples. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells
  12. 272
    “…The patients presented with glioblastoma, IDH-wildtype at 9 months, 5 years, and 6 years following treatment completion. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Glioblastoma, IDH-wildtype: A New Association with IgM Paraproteinaemic Neuropathy?
  13. 273
    “…BACKGROUND: The accurate grading of IDH-mutant astrocytoma is essential to make therapeutic strategies and assess the prognosis of patients. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Grading of IDH-mutant astrocytoma using diffusion, susceptibility and perfusion-weighted imaging
  14. 274
    “…Between February 2017 and July 2018, ten patients were enrolled, six with IDH1-mutant and four with IDH1 wild-type gliomas. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Detection of IDH1 Mutations in Plasma Using BEAMing Technology in Patients with Gliomas
  15. 275
    “…The majority of these tumors harbor mutations in either IDH1 or IDH2. Glutamine metabolism has been implicated as a critical regulator of tumors with IDH mutations. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Distinct Roles of Glutamine Metabolism in Benign and Malignant Cartilage Tumors With IDH Mutations
  16. 276
    por Shi, Diana D., Savani, Milan R., Levitt, Michael M., Wang, Adam C., Endress, Jennifer E., Bird, Cylaina E., Buehler, Joseph, Stopka, Sylwia A., Regan, Michael S., Lin, Yu-Fen, Puliyappadamba, Vinesh T., Gao, Wenhua, Khanal, Januka, Evans, Laura, Lee, Joyce H., Guo, Lei, Xiao, Yi, Xu, Min, Huang, Bofu, Jennings, Rebecca B., Bonal, Dennis M., Martin-Sandoval, Misty S., Dang, Tammie, Gattie, Lauren C., Cameron, Amy B., Lee, Sungwoo, Asara, John M., Kornblum, Harley I., Mak, Tak W., Looper, Ryan E., Nguyen, Quang-De, Signoretti, Sabina, Gradl, Stefan, Sutter, Andreas, Jeffers, Michael, Janzer, Andreas, Lehrman, Mark A., Zacharias, Lauren G., Mathews, Thomas P., Losman, Julie-Aurore, Richardson, Timothy E., Cahill, Daniel P., DeBerardinis, Ralph J., Ligon, Keith L., Xu, Lin, Ly, Peter, Agar, Nathalie Y.R., Abdullah, Kalil G., Harris, Isaac S., Kaelin, William G., McBrayer, Samuel K.
    Publicado 2022
    “…Mutations affecting isocitrate dehydrogenase (IDH) enzymes are prevalent in glioma, leukemia, and other cancers. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
  17. 277
    “…Leptomeningeal metastasis of glioblastoma (GBM), IDH-wildtype to Meckel’s cave is rare. We encountered a case of leptomeningeal metastasis of GBM to Meckel’s cave in an elderly female patient who presented with pain around her right eye. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Glioblastoma, IDH-wildtype with leptomeningeal metastasis to Meckel’s cave: A case report
  18. 278
    “…OBJECTIVE: IDH-mutant lower-grade gliomas (LGGs, grade 2 or 3) eventually transform into secondary grade 4 astrocytomas (sA(IDHmut/G4)). …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Radiotherapy delays malignant transformation and prolongs survival in patients with IDH-mutant gliomas
  19. 279
    “…SIX4 promotes progression of osteosarcoma via upregulating isocitrate dehydrogenase 1 (IDH1), which provides novel prognostic biomarkers and promising therapeutic targets for osteosarcoma patients.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    SIX4 upregulates IDH1 and metabolic reprogramming to promote osteosarcoma progression
  20. 280
    “…BACKGROUND: We aimed to evaluate the mutation profile, transcriptional variants, and prognostic impact of the epidermal growth factor receptor (EGFR) gene in isocitrate dehydrogenase (IDH)‐wildtype glioblastomas (GBMs). METHODS: We sequenced EGFR, evaluated the EGFR splicing profile using a next‐generation sequencing oncopanel, and analyzed the outcomes in 138 grade IV IDH‐wildtype GBM cases. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Distribution and favorable prognostic implication of genomic EGFR alterations in IDH ‐wildtype glioblastoma
Herramientas de búsqueda: RSS