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  1. 2801
    “…RECENT FINDINGS: Tumor molecular markers as IDH1 mutation and MGMT methylation status may provide future treatment targets. …”
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    Online Artículo Texto
    Seizure Management and Prophylaxis Considerations in Patients with Brain Tumors
  2. 2802
    “…Pediatric and adult IDH-wildtype gliomas (GBM) differ in both their clinical and molecular characteristics. …”
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    DIPG-56. PEDIATRIC GLIOMAS EXHIBIT A UNIQUE LIPID METABOLIC PHENOTYPE DISTINCT FROM ADULT GBMS
  3. 2803
    “…Immunohistochemistry (IHC) for PD-1 and FOXP3 was performed on paraffin-embedded tissue sections manually and their expressions were noted. Data on IDH1 mutational status and mitotic index was collected and statistically analyzed. …”
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    Immunohistochemical Analysis of PD-1 and FOXP3 in Tumor-Infiltrating Lymphocytes in Human Gliomas
  4. 2804
    “…Methods: We examined 138 plasma samples from 36 patients with isocitrate dehydrogenase (IDH) wild-type glioblastoma at multiple stages of treatment. …”
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    Profile Characterization of Biogenic Amines in Glioblastoma Patients Undergoing Standard-of-Care Treatment
  5. 2805
    “…From a biological perspective, it has been observed that ten-eleven translocators (TET2) mutated T lymphocytes tend to polarize to TFH, while Tregs lose their inhibitory properties. IDH2 R172 was shown to have inhibitory effects on TET2, mimicking the effects of TET2 mutations, as well as having effects on histone methylation. …”
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    The Role of Epigenetic Modifier Mutations in Peripheral T-Cell Lymphomas
  6. 2806
    “…To decipher the RAR-dependent and RAR-independent effects of RXR, the genes encoding the RAR or RXR isotypes were functionally inactivated by CRISPR/Cas9-mediated editing in an IDH1-/p53-positive SLGC line with good responsiveness to RA. …”
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    RAR-Dependent and RAR-Independent RXR Signaling in Stem-like Glioma Cells
  7. 2807
    “…Transgenic tomato (Solanum lycopersicum) plants were generated expressing a fragment of the mitochondrial NAD-dependent isocitrate dehydrogenase gene (SlIDH1) in the antisense orientation. The transgenic plants displayed a mild reduction in the activity of the target enzyme in the leaves but essentially no visible alteration in growth from the wild-type. …”
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    Mild Reductions in Mitochondrial NAD-Dependent Isocitrate Dehydrogenase Activity Result in Altered Nitrate Assimilation and Pigmentation But Do Not Impact Growth
  8. 2808
    “…Since TET proteins and many lysine demethylases require 2-oxoglutarate as a cofactor, aberrations in cofactor biochemical pathways, including mutations in isocitrate dehydrogenase (IDH), may affect levels of 5hmC and 5mC in certain types of tumors, either directly or indirectly. …”
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    5-hydroxymethylcytosine and its potential roles in development and cancer
  9. 2809
    “…For all of the following biomarkers the present evidence level for clinical utility was regarded as lower than that of 1p/19q status: MGMT gene promoter methylation testing (glioblastoma), IDH mutation testing (diffusely growing gliomas), BRAF fusion testing (pilocytic astrocytoma) and CIMP testing (diffusely growing gliomas). …”
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    Clinical Neuropathology Practice News 4-2012: levels of evidence for brain tumor biomarkers
  10. 2810
    “…These analyses identified highly recurrent epigenetic factor mutations in TET2, DNMT3A and IDH2 as well as a new highly prevalent RHOA p.Gly17Val (NM_001664) mutation present in 22/35 (67%) of angioimmunoblastic T-cell lymphomas (AITL) and in 8/44 (18%) not otherwise specified PTCL (PTCL NOS) samples. …”
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    Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas
  11. 2811
    “…Oncogenic activating mutations are now known to occur in a number of epigenetic modifiers (i.e. IDH1/2, EZH2, DNMT3A), pinpointing epigenetic pathways that are involved in tumorigenesis. …”
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    Driver mutations of cancer epigenomes
  12. 2812
    “…RESULTS: A majority (63.3%) of patients were in the 16-59 years age group. 75% of patients had attended the IDH for rabies post-exposure prophylaxis (PEP) within 24 hours. …”
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    Epidemiological Characteristics of Patients Attending for Rabies Post-Exposure Prophylaxis at the Infectious Diseases Hospital of Lucknow, India
  13. 2813
    “…Using data acquired from the Cancer Genome Atlas (TCGA), we show that CD97 is upregulated among the classical and mesenchymal subtypes of GBM and significantly decreased among IDH1 mutant GBMs. Given its proven roles in tumor invasion, expression among aggressive genetic subtypes of GBM, and association with overall survival, CD97 is an attractive therapeutic target for patients with GBM.…”
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    Proportional Upregulation of CD97 Isoforms in Glioblastoma and Glioblastoma-Derived Brain Tumor Initiating Cells
  14. 2814
    por Lin, Qiong, Wagner, Wolfgang
    Publicado 2015
    “…For example, in acute myeloid leukemia (AML) higher epigenetic age-predictions are associated with increased incidence of mutations in RUNX1, WT1, and IDH2, whereas mutations in TET2, TP53, and PML-PARA translocation are more frequent in younger age-predictions. …”
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    Epigenetic Aging Signatures Are Coherently Modified in Cancer
  15. 2815
    “…Three energy metabolism related genes (MT-ND6, Idh2, and Acadl) were upregulated when mitoK(ATP) opened. …”
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    Genome-Wide Expression Profiling of Anoxia/Reoxygenation in Rat Cardiomyocytes Uncovers the Role of MitoK(ATP) in Energy Homeostasis
  16. 2816
    “…Chromosomal copy number aberrations (CNAs), IDH 1/2 mutations, MGMT promoter methylation, and expression of p53 and ATRX were assessed. …”
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    Molecular–genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort
  17. 2817
    por Zhang, Chang-Ming, Brat, Daniel J.
    Publicado 2016
    “…Molecular classes were closely aligned with the status of isocitrate dehydrogenase (IDH) mutations, tumor protein 53 mutations and the co-deletion of chromosome arms 1p and 19q, but were not closely aligned with histologic classes. …”
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    Genomic profiling of lower-grade gliomas uncovers cohesive disease groups: implications for diagnosis and treatment
  18. 2818
    “…Herein, we report the experimental validation of the proposed reannotations for two such genes (KB1_0495 and KB1_0553) from D . mccartyi strains in the KB‐1 community. KB1_0495 or DmIDH was originally annotated as an NAD (+)‐dependent isocitrate dehydrogenase, but biochemical assays revealed its activity primarily with NADP (+) as a cofactor. …”
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    Experimental validation of in silico model‐predicted isocitrate dehydrogenase and phosphomannose isomerase from D ehalococcoides mccartyi
  19. 2819
    “…Among these patients, 98.4% had a unique molecular profile, and aside from three primary brain tumor patients with a single genetic lesion (IDH1 R132H), no two patients within a given histology were molecularly identical. …”
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    Molecular inimitability amongst tumors: implications for precision cancer medicine in the age of personalized oncology
  20. 2820
    “…While no cell line carried IDH1 mutations, five cell lines showed hTERT promoter activating mutations with a concomitant increase in hTERT transcript levels. …”
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    Elucidating the cancer-specific genetic alteration spectrum of glioblastoma derived cell lines from whole exome and RNA sequencing
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