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  1. 2821
    “…Hypermethylation was significantly associated with IDH1/2 mutation. Comparative SNP analysis indicates higher incidence of loss of heterozygosity of MTSS1 in anaplastic astrocytomas and secondary glioblastomas as well as hypermethylation of the remaining allele. …”
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    MTSS1 is epigenetically regulated in glioma cells and inhibits glioma cell motility
  2. 2822
    “…Patients with defects in TET2 molecule show better response to treatment with azacitidine. IDH and DNMT3A mutations are associated with a good response to decitabine therapy. …”
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    Genetics and Epigenetics of Myelodysplastic Syndromes and Response to Drug Therapy: New Insights
  3. 2823
    por Koeffler, H P, Leong, G
    Publicado 2017
    “…More recently, investigators noted that AML patients who achieved complete morphological remission after chemotherapy often have clonal hematopoiesis predominantly marked by either DNMT3A, TET2 or IDH1/2 mutations, which were also present at diagnosis of AML. …”
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    Preleukemia: one name, many meanings
  4. 2824
    “…In a small cohort of glioma patients, we finally demonstrated that peripheral blood EVs cargo can be successfully used to detect the presence of IDH1(G395A), an essential biomarker in the current management of human glioma…”
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    DNA sequences within glioma-derived extracellular vesicles can cross the intact blood-brain barrier and be detected in peripheral blood of patients
  5. 2825
    “…Molecular biological analyses revealed the absence of histone H3.3 mutation (H3F3A K27M), and presence of methylation of O-6-methylguanine-DNA methyltransferase (MGMT) promoter and a mutation in isocitrate dehydrogenase 1 (IDH-1). The patient received local radiotherapy and temozolomide chemotherapy. …”
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    Adult Diffuse Astrocytoma in the Medulla Oblongata: Molecular Biological Analyses Including H3F3A Mutation of Histone H3.3
  6. 2826
    “…In multivariate analysis, co-polysomy maintained an independent prognostic impact on survival (P=0.001) after adjustment for age, KPS, grade, removal degree, tumor size, Ki-67 index, and IDH1/2. In the WHO(2016) cohort (N=572), we validated the prognostic merit of co-polysomy after adjusting for related factors. …”
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    1q/19p co-polysomy predicts longer survival in patients with astrocytic gliomas
  7. 2827
    “…Genomic profiling of patient tumor and normal sample identified a TP53 germline mutation with loss of heterozygosity, somatic mutations including IDH2, and aberrant activation of biological pathways. …”
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    Molecular Guided Therapy Provides Sustained Clinical Response in Refractory Choroid Plexus Carcinoma
  8. 2828
    “…NAMPT signature also correlates directly with EGFR positive and IDH negative tumors. Finally, NAMPT inhibition increases sensitivity to apoptosis in both NAMPT-expressing cells and tumorspheres. …”
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    NAMPT overexpression induces cancer stemness and defines a novel tumor signature for glioma prognosis
  9. 2829
    “…Such signature resolves the heterogeneous class of IDH-wild type lower-grade gliomas, identifying the patients with worse prognosis independently from clinical and molecular features (p = 0·03, by Cox proportional-hazards model). …”
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    Specific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivo
  10. 2830
    “…In univariate and multivariate analysis, LGALS3 expression independently predicted shorter OS in the proneural subtype of GBM (HR: 1.487, 95% CI: 1.229‐1.798, P < 0.001), after adjustment of age, gender, IDH1 mutations, temozolomide chemotherapy, radiotherapy and LGALS3BP expression. …”
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    Increased LGALS3 expression independently predicts shorter overall survival in patients with the proneural subtype of glioblastoma
  11. 2831
    “…Analyses of 28 PPGL tumor tissues using the dedicated PPGL panel revealed pathogenic or likely pathogenic variants in known PPGL susceptibility genes in 21 (75%) cases, including mutations in IDH2, ATRX and HRAS. These mutations suggest sporadic tumor development. …”
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    Optimizing Genetic Workup in Pheochromocytoma and Paraganglioma by Integrating Diagnostic and Research Approaches
  12. 2832
    “…In application to the glioblastoma dataset from The Cancer Genome Atlas, MHN proposed a novel interaction in line with consecutive biopsies: IDH1 mutations are early events that promote subsequent fixation of TP53 mutations. …”
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    Modelling cancer progression using Mutual Hazard Networks
  13. 2833
    “…SHCBP1 was enriched in the cell cycle, DNA replication, ECM receptor interaction, and P53 signaling pathway. Age, grade, IDH status, chromosome 19/20 cogain, and SHCBP1 were independent factors for prognosis. …”
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    PART1 and hsa-miR-429-Mediated SHCBP1 Expression Is an Independent Predictor of Poor Prognosis in Glioma Patients
  14. 2834
    “…A germline NOTCH1 missense mutation was identified in the peripheral blood sample, the primary tumor and the relapse tumor; in addition, we identified a tumor protein p53 (TP53) heterozygous nonsense mutation in the primary tumor and a TP53 homozygous nonsense mutation and an IDH1 heterozygous missense mutation in the relapse tumor. …”
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    From astrocytoma to glioblastoma: a clonal evolution study
  15. 2835
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    SARS-CoV-2: The viral shedding vs infectivity dilemma
  16. 2836
    “…In gliomas with high PDIA3 expression, somatic mutations showed the correlation with loss of PTEN and amplification of EGFR; meanwhile, in PDIA3 low gliomas, mutations in isocitrate dehydrogenase (IDH) took 80%. Moreover, PDIA3 was found to positively correlate with ESTIMATE scores and diverse infiltrating immune and stromal cell types localizing in tumor microenvironment. …”
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    PDIA3 correlates with clinical malignant features and immune signature in human gliomas
  17. 2837
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    Antiviral efficacy of personal care formulations against Severe Acute Respiratory Syndrome Coronavirus 2
  18. 2838
    “…Finally, a nomogram composed of the GDRG signature, age, pharmacotherapy, radiotherapy, IDH mutations and MGMT promoter methylation was generated and validated in two large GBM cohorts to predict GBM prognosis. …”
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    Glioblastoma cell differentiation trajectory predicts the immunotherapy response and overall survival of patients
  19. 2839
    “…They included proteins involved in ER stress (GRP78, and endoplasmin), mitochondrial proteins (GRP75, ECHM, IDH3A, NDUS1, and NDUS3), proteins involved in the maintenance of the cell morphology (EFHD2, TCPA, NDRG1, and ezrin), and some other proteins (HNRPF, HNRH1, K2C8, vimentin, PBDC1, EF2, PCNA, biliverdin reductase, G3BP1, FRIL, and HSP27). …”
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    Markers of acute toxicity of DDT exposure in pancreatic beta-cells determined by a proteomic approach
  20. 2840
    “…Several other novel agents including orally available and longer acting HMAs, the BCL-2 inhibitor venetoclax, oral agents targeting driver mutations (IDH1/2, FLT3), immunotherapies, and new options for intensive chemotherapy have been studied with variable success and will be reviewed herein. …”
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    Emerging treatment options for patients with high-risk myelodysplastic syndrome
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