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281por Zorzan, Eleonora, Hanssens, Katia, Giantin, Mery, Dacasto, Mauro, Dubreuil, Patrice“…In the present study, the mutational profile of the Tet methylcytosine dioxygenase 2 (TET2), the isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2), the serine/arginine-rich splicing factor 2 (SRSF2), the splicing factor 3b subunit 1 (SF3B1), the Kirsten rat sarcoma viral oncogene homolog (KRAS) and the neuroblastoma RAS viral oncogene homolog (NRAS), commonly mutated in human myeloid malignancies and mastocytosis, was investigated in canine MCTs. …”
Publicado 2015
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282por Cai, Hong-Qing, Wang, Peng-Fei, Zhang, Hai-Peng, Cheng, Zhi-Jian, Li, Shou-Wei, He, Jie, Zhang, Yu, Hao, Jia-Jie, Wang, Ming-Rong, Yan, Chang-Xiang, Wan, Jing-Hai“…ATRX(-)/IDH1(R132H)showed the longest median survival (19.6 months). …”
Publicado 2018
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283“…SIMPLE SUMMARY: Isocitrate dehydrogenase 3α (IDH3α) is highly expressed in many cancers and is associated with poor patient prognosis. …”
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284por Shi, Diana D., Lee, Joyce H., Wang, Adam C., Khanal, Januka, Gao, Wenhua, Kaelin, William G., McBrayer, Samuel K.“…Lower-grade gliomas exhibit a high prevalence of isocitrate dehydrogenase 1 (IDH1) mutations, but faithful models for studying these tumors are lacking. …”
Publicado 2023
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285por Kaye, Brandon, Ali, Assad, Correa Bastianon Santiago, Raphael Augusto, Ibrahim, Bilal, Isidor, Julio, Awad, Hany, Sabahi, Mohammadmahdi, Obrzut, Michal, Adada, Badih, Ranjan, Surabhi, Borghei-Razavi, Hamid“…Methods: Two hundred ninety-three consecutive patients with IDH wild-type GBM were included in the analysis. …”
Publicado 2023
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286por Garrett, Matthew C., Albano, Rebecca, Carnwath, Troy, Elahi, Lubayna, Behrmann, Catherine A., Pemberton, Merissa, Woo, Daniel, O’Brien, Eric, VanCauwenbergh, Brett, Perentesis, John, Shah, Sanjit, Hagan, Matthew, Kendler, Ady, Zhao, Chuntao, Paranjpe, Aditi, Roskin, Krishna, Kornblum, Harley, Plas, David R., Lu, Q. Richard“…Low-grade and secondary high-grade gliomas frequently contain mutations in the IDH1 or IDH2 metabolic enzymes that are hypothesized to drive tumorigenesis by inhibiting many of the chromatin-regulating enzymes that regulate DNA structure. …”
Publicado 2023
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287por Zhang, Yunxiao, Wen, Yunyu, Nie, Jing, Wang, Tong, Wang, Gang, Gao, Qiaoping, Cao, Yongfu, Wang, Hai, Qi, Songtao, Xie, Sidi“…In this study, weighted gene coexpression network analysis (WGCNA) was performed to analyze RNA binding protein (RBP) expression data from The Cancer Genome Atlas (TCGA) for the IDH-wild type GBM cohort. The CIBERSORT algorithm quantified the cellular composition of immune cells and was used to identify key modules associated with CD8+ T cell infiltration. …”
Publicado 2023
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289por Zarnegar-Lumley, Sara, Alonzo, Todd A., Gerbing, Robert B., Othus, Megan, Sun, Zhuoxin, Ries, Rhonda E., Wang, Jim, Leonti, Amanda, Kutny, Matthew A., Ostronoff, Fabiana, Radich, Jerald P., Appelbaum, Frederick R., Pogosova-Agadjanyan, Era L., O’Dwyer, Kristen, Tallman, Martin S., Litzow, Mark, Atallah, Ehab, Cooper, Todd M., Aplenc, Richard A., Abdel-Wahab, Omar, Gamis, Alan S., Luger, Selina, Erba, Harry, Levine, Ross, Kolb, E. Anders, Stirewalt, Derek L., Meshinchi, Soheil, Tarlock, Katherine“…Somatic mutations in isocitrate dehydrogenase (IDH) genes occur frequently in adult acute myeloid leukemia (AML) and less commonly in pediatric AML. …”
Publicado 2023
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290por Blanco-Carmona, Enrique, Narayanan, Ashwin, Hernandez, Inmaculada, Nieto, Juan C., Elosua-Bayes, Marc, Sun, Xueyuan, Schmidt, Claudia, Pamir, Necmettin, Özduman, Koray, Herold-Mende, Christel, Pagani, Francesca, Cominelli, Manuela, Taranda, Julian, Wick, Wolfgang, von Deimling, Andreas, Poliani, Pietro Luigi, Rehli, Michael, Schlesner, Matthias, Heyn, Holger, Turcan, Şevin“…The isocitrate dehydrogenase (IDH) gene is recurrently mutated in adult diffuse gliomas. …”
Publicado 2023
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291The Frequency and Clinical Significance of IDH1 Mutations in Chinese Acute Myeloid Leukemia Patients“…IDH1 mutations are significant in both diagnosis and prognosis of these conditions. …”
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292por Akbay, Esra A., Moslehi, Javid, Christensen, Camilla L., Saha, Supriya, Tchaicha, Jeremy H., Ramkissoon, Shakti H., Stewart, Kelly M., Carretero, Julian, Kikuchi, Eiki, Zhang, Haikuo, Cohoon, Travis J., Murray, Stuart, Liu, Wei, Uno, Kazumasa, Fisch, Sudeshna, Jones, Kristen, Gurumurthy, Sushma, Gliser, Camelia, Choe, Sung, Keenan, Marie, Son, Jaekyoung, Stanley, Illana, Losman, Julie A., Padera, Robert, Bronson, Roderick T., Asara, John M., Abdel-Wahab, Omar, Amrein, Philip C., Fathi, Amir T., Danial, Nika N., Kimmelman, Alec C., Kung, Andrew L., Ligon, Keith L., Yen, Katharine E., Kaelin, William G., Bardeesy, Nabeel, Wong, Kwok-Kin“…Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) have been discovered in several cancer types and cause the neurometabolic syndrome D2-hydroxyglutaric aciduria (D2HGA). …”
Publicado 2014
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293por Mäkelä, Katri, Nordfors, Kristiina, Finne, Jukka, Jokilammi, Anne, Paavonen, Timo, Haapasalo, Hannu, Korja, Miikka, Haapasalo, Joonas“…PolySia expression was significantly stronger in IDH1 mutated tumors than in IDH1 non-mutated (p = 0.001, chi-square test). …”
Publicado 2014
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294por Chittaranjan, Suganthi, Chan, Susanna, Yang, Cindy, Yang, Kevin C., Chen, Vincent, Moradian, Annie, Firme, Marlo, Song, Jungeun, Go, Nancy E., Blough, Michael D., Chan, Jennifer A., Cairncross, J. Gregory, Gorski, Sharon M., Morin, Gregg B., Yip, Stephen, Marra, Marco A.“…The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K). Approximately 70% of ODGs with 1p19q co-deletions harbor somatic mutations in the Capicua Transcriptional Repressor (CIC) gene on chromosome 19q13.2. …”
Publicado 2014
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295por Myung, Jae Kyung, Cho, Hwa jin, Kim, Hanna, Park, Chul-Kee, Lee, Se Hoon, Choi, Seung Hong, Park, Peom, Yoon, Jung Min, Park, Sung-Hye“…GBMO could be divided into two groups based on the presence of an IDH1 mutation. The IDH1 mutation was more frequently found in secondary GBMO, which had lower frequencies of EGFR amplification but higher MGMT methylation than the wild type IDH1 group, and patients with mutant IDH1 GBMO were on average younger than those with wild-type IDH1. …”
Publicado 2014
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296por Moriya, Kunihiko, Kaneko, Mika K, Liu, Xing, Hosaka, Masami, Fujishima, Fumiyoshi, Sakuma, Jun, Ogasawara, Satoshi, Watanabe, Mika, Sasahara, Yoji, Kure, Shigeo, Kato, Yukinari“…We report on a 24-year-old woman who was diagnosed as having Maffucci syndrome with anaplastic astrocytoma. We analyzed the IDH1 and IDH2 mutations of enchondroma, hemangioma and anaplastic astrocytoma tissues and the same somatic mosaic mutation in IDH2 gene was identified in all these tissues. …”
Publicado 2014
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297por Xia, Liang, Wu, Bin, Fu, Zhiquan, Feng, Fang, Qiao, Enqi, Li, Qinglin, Sun, Caixing, Ge, Minghua“…We performed a meta-analysis of the association between IDH mutations and survival in gliomas. METHODS: Pubmed and EMBASE databases were searched for studies reporting IDH mutations (IHD1/2 and IDH1) and survival in gliomas. …”
Publicado 2015
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298por Ebrahimi, Azadeh, Skardelly, Marco, Bonzheim, Irina, Ott, Ines, Mühleisen, Helmut, Eckert, Franziska, Tabatabai, Ghazaleh, Schittenhelm, Jens“…ATRX loss in astrocytomas was also strongly associated with IDH1/2 and H3F3A mutation (p < 0.0001). Among 196 glial tumors with nuclear ATRX loss, 173 (89 %) had an IDH1 or IDH2 mutation. …”
Publicado 2016
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299“…A total of 15.3% of enrolled GBMs demonstrated loss of ATRX expression (ATRX-), 10.4% expressed an aberrant IDH1 R132H protein (IDH1+), and 48.4% exhibited p53 overexpression (p53+). …”
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300por Cha, Hanvit, Lee, Seoyoon, Hwan Kim, Sung, Kim, Hyunjin, Lee, Dong-Seok, Lee, Hyun-Shik, Lee, Jin Hyup, Park, Jeen-Woo“…Therefore, we evaluated the role of IDH2 in DSS-induced colitis using IDH2-deficient (IDH2(-/-)) mice. …”
Publicado 2017
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