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3001por van Nes, Karin Alexandra, van Loveren, Cor, Luteijn, Michiel Fridthjof, Slot, Dagmar ElseEnlace del recurso
Publicado 2022
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3002“…Alterations in genes such as the FGFR, HER2, IDH1, and BRAF, result in cancer development, growth, and proliferation. …”
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3003por Ding, Yuxuan, Wang, Qiang, Wang, Feijiang, Wu, Nan, Li, Jianrui, He, Xia, Pan, Hao, Wang, Lijun“…Epithelioid glioblastoma (EGBM, classified as glioblastoma, IDH wild type, grade 4 according to the fifth edition of the World Health Organization (WHO) Classification of Tumors of the Central Nervous System (CNS) (WHO CNS5)) is a highly aggressive malignancy, with a median progression-free survival (mPFS) of about 6 months in adults. …”
Publicado 2023
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3004por Prener, Martin, Opheim, Giske, Shams, Zahra, Søndergaard, Christian Baastrup, Lindberg, Ulrich, Larsson, Henrik B. W., Ziebell, Morten, Larsen, Vibeke Andrée, Vestergaard, Mark Bitsch, Paulson, Olaf B.“…Three of the patients, including the MRS 2-HG-negative patient, were operated on, and all of them had the IDH mutation. Conclusion: Our findings were consistent with the existing literature on 3T and 7T MRS.…”
Publicado 2023
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3005Adenylate kinase 2 is a biomarker related to the prognosis of glioma and the immune microenvironment“…Older patients and those with higher‐grade, IDH‐wildtype, 1p/19q codeletion‐free, and MGMT‐unmethylated tumors had higher levels of AK2 expression, linking to poor outcomes. …”
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3006por Ah-Pine, F., Khettab, M., Bedoui, Y., Slama, Y., Daniel, M., Doray, B., Gasque, P.“…Glioblastoma, IDH wild-type is the most common and aggressive form of glial tumors. …”
Publicado 2023
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3007por Lessi, Francesca, Morelli, Mariangela, Franceschi, Sara, Aretini, Paolo, Menicagli, Michele, Marranci, Andrea, Pasqualetti, Francesco, Gambacciani, Carlo, Pieri, Francesco, Grimod, Gianluca, Zucchi, Vanna, Cupini, Samanta, Di Stefano, Anna Luisa, Santonocito, Orazio Santo, Mazzanti, Chiara Maria“…We collected blood samples from a recurrent IDH wt GBM patient. We genotyped the parental recurrent tumor tissue and the respective primary GBM tissue. …”
Publicado 2023
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3008por Jahanshahi, Amirreza, Salarinejad, Sareh, Oraee-Yazdani, Saeed, Chehresonboll, Yasaman, Morsali, Soroush, Jafarizadeh, Ali, Falahatian, Masih, Rahimi, Faezeh, Jaberinezhad, Mehran“…The pathology results revealed adult-type diffuse glioma with isocitrate dehydrogenase (IDH) mutation. Bilateral blindness, as well as bilateral temporal lobe involvement, each has many different causes. …”
Publicado 2023
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3009por Chatha, Gurkirat, Dhaliwal, Tarundeep, Castle-Kirszbaum, Mendel David, Amukotuwa, Shalini, Lai, Leon, Kwan, Edward“…Average vessel density did not correlate with age, sex, previous treatment, or IDH status. CONCLUSIONS: ASL PWI imaging is a reliable marker of evaluating the vascularity of high grade gliomas and may be used as an adjunct to DSC PWI.…”
Publicado 2023
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3010“…These combinations include isocitrate dehydrogenase-1/2 (IDH1/2) inhibitors (i.e., ivosidenib and enasidenib), fms-like tyrosine kinase 3 (FLT3) inhibitors (i.e., gilteritinib), anti-CD47 antibodies (i.e., magrolimab), mouse double minute-2 (MDM2) inhibitors, and p53 reactivators (i.e., eprenetapopt). …”
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3011“…Diabetic β-cells showed dataset-specific patterns of DEGs (FDR ≤ 0.05) implicated in the regulation of glutathione metabolism (ANPEP, PGD, IDH2, and CTH), protein-folding (HSP90AB1, HSP90AA1, HSPA1B, HSPA8, BAG3, NDC1, NUP160, RLN1, and RPS19BP1), and unfolded protein response (CREB3L4, ERP27, and BID). …”
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3012“…MEG3 expression was compared in patient‐derived glioma cells concerning IDH1 mutation and WHO grades. Silencing of MEG3 inhibited cell proliferation and reduced cell migration while overexpression of MEG3 promoted proliferation in glioma cells. …”
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3013por Todorova, Valentina K., Byrum, Stephanie D., Mackintosh, Samuel G., Jamshidi-Parsian, Azemat, Gies, Allen J., Washam, Charity L., Jenkins, Samir V., Spiva, Timothy, Bowman, Emily, Reyna, Nathan S., Griffin, Robert J., Makhoul, Issam“…The functional analysis of the differentially expressed exosomal miRNAs (i.e., mir-483, mir-133a, mir-34a, mir-155, mir-183, mir-182), their predicted targets, and exosomal differentially expressed proteins (i.e., POSTN, STAM, EXOC8, SNX9, COL1A2, IDH1, FN1) showed correlation with pathways associated with HBV, virus activity and invasion, exosome formation and adhesion, and exogenous protein binding. …”
Publicado 2023
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3014por Klingenschmid, Julia, Krigers, Aleksandrs, Schön, Victoria, Pinggera, Daniel, Kerschbaumer, Johannes, Grams, Astrid E., Thomé, Claudius, Freyschlag, Christian F.“…RESULTS: Female gender has shown significant correlation with TMT, while TMT did not correlate with preoperative and follow-up functional scores, age, WHO classification, IDH mutation, MGMT promoter methylation, EGFR and ATRX expression, or 1p/19q co-deletion. …”
Publicado 2023
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3015por Sun, Jin-Min, Fan, Hong-Ye, Zhu, Yan, Pan, Ting-Ting, Wu, Yong-Ping, Zhang, Dao-Yong, Hou, Xiao-Yu“…High levels of MAP4K1 mRNA were prevalent in IDH-WT and 1p/19q non-codeletion gliomas and correlated with poor prognosis of patients. …”
Publicado 2023
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3016por Sahm, Felix, Brandner, Sebastian, Bertero, Luca, Capper, David, French, Pim J, Figarella-Branger, Dominique, Giangaspero, Felice, Haberler, Christine, Hegi, Monika E, Kristensen, Bjarne W, Kurian, Kathreena M, Preusser, Matthias, Tops, Bastiaan B J, van den Bent, Martin, Wick, Wolfgang, Reifenberger, Guido, Wesseling, Pieter“…Additionally, because of its importance as a predictive marker in IDH-wildtype glioblastomas, tools for the analysis of MGMT promoter methylation status are covered. …”
Publicado 2023
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3017por Zhang, Lei, Martin, Greg, Mohankumar, Kumaravel, Wright, Gus A., Mariyam, Fuada, Safe, Stephen“…Piperlongumine also downregulated the pro-reductant isocitrate dehydrogenase 1 (IDH1) and thioredoxin domain-containing 5 (TXNDC5) gene products resulting in the induction of ROS as previously observed for other inverse NR4A1 agonists. …”
Publicado 2023
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3018por Guo, Yangyang, Bao, Jingxia, Lin, Danfeng, Hong, Kai, Cen, Kenan, Sun, Jie, Wang, Zhepei, Wu, Zhixuan“…There were remarkable variations in IDH1 (91% and 64%) across low-as well as high-risk groups. …”
Publicado 2023
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3019por Lu, Yinglin, Zhou, Jing, Li, Fan, Cao, Heng, Zhang, Xingyu, Yu, Debing, He, Zongliang, Ji, Hongjie, Lv, Kunpeng, Wu, Guansuo, Yu, Minli“…The screening of enriched genes showed that hyper-methylation inhibited the expression of Idh3a, Got1, Bcl2, Mylk2, Klf2, Erbin, and Klhl38, and hypo-methylation stimulated the expression of Col22a1, Dnmt3b, Fn1, E2f1, Rprm, and Wfikkn1. …”
Publicado 2023
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3020“…Additionally, TMSB10 exhibited marked elevation in gliomas with wild-type IDH and noncodeletion of 1p/19q. Survival analysis indicated that high TMSB10 expression was significantly associated with worse overall survival, disease-specific survival, and progression-free survival in glioma patients. …”
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