“…We investigated 350 glioma patients for the expression of the key EMT factors SLUG and TWIST by immunohistochemistry and immunofluorescence related to morpho-genetic alterations such as EGFR-amplification, IDH-1 (R132H) mutation and 1p/19q LOH. Furthermore, transcriptional cluster and survival analyses were performed. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Intradural disc herniations (IDH) are rare, particularly in the cervical spine, where they account for less than 5% of all discs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mutations in certain mitochondrial proteins, such as IDH2 have been shown to contribute to leukemogenesis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In contrast, isocitrate dehydrogenase 2 (Idh2) gene deletion, which results in defect of the NADPH-associated mitochondrial antioxidant system, exacerbated cisplatin-induced changes in mice. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Using a publicly available data set of magnetic resonance imaging images from patients diagnosed with low-grade gliomas, we demonstrated that the dictionary-based model performs well in predicting 2 biomarkers of interest (1p/19q codeletion and IDH1 mutation). Furthermore, the visual regions (atoms) associated with these dictionaries show association with key molecular pathways implicated in gliomagenesis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…So far, multiple efforts have focused on single specific metabolic enzymes responsible for the altered Krebs cycle in human cancers, including metformin for ETC complex I, IDH1/2 inhibitors, PDH inhibitor CPI-613, MPC1/2 inhibitor UK5099, MCT1 inhibitor AZD3965, CPT1 inhibitors etomoxir/perhexiline/ST1326, FASN inhibitor orlistat/TVB-2640, MCD inhibitor CBM-301106, ACAA2 inhibitor trimetazidine. …”
Enlace del recurso
Enlace del recurso

“…However, CAP also affected bacterioferritin (Bfr), Isocitrate dehydrogenase (Idh), Trigger factor (Tig) and a chemotaxis protein, which may be involved in P. aeruginosa’s specific response to CAP. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Sequencing DNA from the three AMLs revealed somatic mutations homologous to those considered to be drivers of human AML, including predicted loss- or gain-of-function mutations in Tet2, Gata2, Idh1, and Ikzf1. However, the engineered U2af1(S34F) missense mutation reverted to WT in two of the three AML cases, implying that U2af1(S34F) is dispensable, or even selected against, once leukemia is established.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The patient underwent urgent tumor resection, and histologic results revealed an IDH-mutant glioblastoma multiforme. The patient was discharged with a substantially improved psychopathology and without neurological deficits. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: We found that ADAMTSL4 was enriched in GBM (WHO grade IV), especially for those with IDH1/2 wild-type and MGMT unmethylated groups. According to the TCGA classification scheme, ADAMTSL4 can act as a potential marker for subtypes with poorer prognosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Primary brain tumor initiating cell lines from IDH-wild type GBM stably expressing H2B-Dendra2 were implanted orthotopically in the brains of SCID mice. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mutations in isocitrate dehydrogenase (IDH) or a reduced expression of L-2-hydroxyglutarate (HG)-dehydrogenase result in accumulation of D-2-HG or L-2-HG, respectively, in tumor tissues. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Isocitrate dehydrogenase (IDH) mutation is the most recently introduced molecular marker and is important for the GBM classification because distinguishes primary (de novo) from secondary GBM. …”
Enlace del recurso
Enlace del recurso

“…Based on the transcriptional quantification of DNA modification genes (dnmt, tet, and tdg) and their candidate regulators (idh genes, microRNAs, and long non-coding RNAs) and on RNA-protein interaction prediction, we suggest the occurrence of passive demethylation in gonads of FB+ and 5hmC loss by Tet inhibition or by 5hmC oxidation in MB+ muscle. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Targeted high‐throughput sequencing revealed the presence of IDH1, SRSF2, and WT1 additional pathogenic mutations. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Results: High DOCK1 expression was associated with older age (P=0.019), wild-type CEBPA (P=0.002), IDH1/2 mutations (P=0.010) and RUNX1 mutation (P=0.005). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, multiple targeted agents are opening opportunities to treat subgroups of patients whose disease harbors mutations in TP53, IDH, FLT3, and genes involved in splicing machinery. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, expression of IGFBP2 mRNA was related to the occurrence of isocitrate dehydrogenase 1 (IDH1) mutation, high heat shock protein 27 (Hsp27) expression and telomerase reverse transcriptase (TERT) promoter mutation (TERTp(+)) (P=0.013, 0.015 and 0.016, respectively), and patients with TERTp(+)/IGFBP2(high) showed the shortest survival. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This risk signature was identified to independently predict the outcome of GBM patients, as well as stratified by IDH1 status, MGMT promoter status, and radio-chemotherapy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We elucidated that the reduction of cellular NAD(+) during the aging process was an important contributor for ARHL; it facilitated oxidative stress and pro‐inflammatory responses in the cochlear tissue through regulating sirtuins that alter various signaling pathways, such as NF‐κB, p53, and IDH2. However, augmentation of NAD(+) by β‐lap effectively prevented ARHL and accompanying deleterious effects through reducing inflammation and oxidative stress, sustaining mitochondrial function, and promoting mitochondrial biogenesis in rodents. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso