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3101por Maschio, Marta, Zarabla, Alessia, Maialetti, Andrea, Giannarelli, Diana, Koudriavtseva, Tatiana, Villani, Veronica, Zannino, Silvana“…There were no significant differences in seizure control in patients with/without IDH1 mutation and with/without MGMT methylation. …”
Publicado 2020
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3102por Xiong, Nanxiang, Gao, Xiaofei, Zhao, Hongyang, Cai, Feng, Zhang, Fang-cheng, Yuan, Ye, Liu, Weichao, He, Fangping, Zacharias, Lauren G., Lin, Hong, Vu, Hieu S., Xing, Chao, Yao, Dong-Xiao, Chen, Fei, Luo, Benyan, Sun, Wenzhi, DeBerardinis, Ralph J., Xu, Hao, Ge, Woo-ping“…Further we verify that D-2-hydroxyglutarate (D-2HG) is high in venous plasma from patients with isocitrate dehydrogenases1 (IDH1) mutations. Through these paired comparisons, we can exclude the interpatient variation that is present in plasma samples usually taken from the cubital vein.…”
Publicado 2020
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3103por Barekatain, Yasaman, Yan, Victoria C., Arthur, Kenisha, Ackroyd, Jeffrey J., Khadka, Sunada, De Groot, John, Huse, Jason T., Muller, Florian L.“…This method can identify tumors with specific oncometabolite alterations such as IDH mutations by 2-hydroxyglutarate and PGD-deleted tumors by gluconate. …”
Publicado 2020
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3104por Kalidindi, Kalyan Kumar Varma, Sath, Sulaiman, Vishwakarma, Gayatri, Chhabra, Harvinder Singh“…CONCLUSION: The 52 patients with CES due to IDH had greater canal compromise versus 56 without CES. …”
Publicado 2020
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3105“…The proposed fully automated method was useful for predicting IDH mutations (sensitivity = 0.93, specificity = 0.88), ATRX mutations (sensitivity = 0.94, specificity = 0.92), chromosome 7/10 aneuploidies (sensitivity = 0.90, specificity = 0.88), and CDKN2 family mutations (sensitivity = 0.76, specificity = 0.86).…”
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3106por Jaedicke, Katrin M., Bissett, Susan M., Finch, Tracy, Thornton, Jared, Preshaw, Philip M.Enlace del recurso
Publicado 2018
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3108por Gameraddin, Moawia, Musa, Walaa Ismail, Abdelmaboud, Suzan, Alshoabi, Sultan, Alsultan, Kamal Dahan, Abdelmalik, Bushra A.“…AIM: To assess sonographic findings of the kidneys in hypertensive patients’ co-morbidities with type 2 diabetes mellitus and ischemic heart disease (IDH). MATERIALS AND METHODS: This was a prospective cross-sectional study involved 100 participants with primary hypertension selected by a method of simple convenient sampling. …”
Publicado 2020
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3109“…Specifically, DGCR5 expression was significantly decreased in GBM and IDH wild-type glioma. Gene ontology analysis showed that DGCR5 was predominantly enriched in immune-related biological processes. …”
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3110por Kim, Dongwoo, Ko, Hae Young, Lee, Sangwon, Lee, Yong-ho, Ryu, Sujin, Kim, Seon Yoo, Chung, Jee-in, Lee, Misu, Moon, Ju Hyung, Chang, Jong Hee, Yun, Mijin“…In addition, the glucose loading PET/CT was more useful than the fasting PET/CT for the discrimination of oligodendrogliomas from IDH-wildtype glioblastomas. Glucose loading resulted in a greater reduction in (18)F-FDG uptake in the normal cortex than in tumors, which increases the usefulness of (18)F-FDG PET/CT for grading.…”
Publicado 2020
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3111“…The understanding of the molecular landscape of BTC has offered hope of targeted therapies to the identified actionable genomic aberrations, such as FGFR2 gene fusions, mutations of IDH1/2, HER2, BRAC1/2 and BRAF. Pembigatinib has become the first approved targeted therapy for BTC with FGFR2 fusion or other rearrangements. …”
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3112por Ott, Martina, Tomaszowski, Karl-Heinz, Marisetty, Anantha, Kong, Ling-Yuan, Wei, Jun, Duna, Maya, Blumberg, Katia, Ji, Xiaorong, Jacobs, Carmen, Fuller, Gregory N., Langford, Lauren A., Huse, Jason T., Long, James P., Hu, Jian, Li, Shulin, Weinberg, Jeffrey S., Prabhu, Sujit S., Sawaya, Raymond, Ferguson, Sherise, Rao, Ganesh, Lang, Frederick F., Curran, Michael A., Heimberger, Amy B.“…CD73 expression was upregulated on immune cells by 2-hydroxyglutarate in IDH1 mutant glioma patients. In murine glioma models, adenosine receptor inhibitors demonstrated a modest therapeutic response; however, the addition of other inhibitors of the adenosine pathway did not further enhance this therapeutic effect. …”
Publicado 2020
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3113por Gale, Andrew N., Sakhawala, Rima M., Levitan, Anton, Sharan, Roded, Berman, Judith, Timp, Winston, Cunningham, Kyle W.“…Knockout mutants of KGD2 and IDH2, which consume and generate alpha-ketoglutarate in mitochondria, exhibited increased and decreased resistance to fluconazole through a process that depended on Pdr1. …”
Publicado 2020
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3114por Caccese, Mario, Ius, Tamara, Simonelli, Matteo, Fassan, Matteo, Cesselli, Daniela, Dipasquale, Angelo, Cavallin, Francesco, Padovan, Marta, Salvalaggio, Alessandro, Gardiman, Marina Paola, Skrap, Miran, Zagonel, Vittorina, Lombardi, Giuseppe“…Alteration of MMR protein expression was statistically more frequent in anaplastic gliomas, in recurrent disease, in patients treated with temozolomide, and in IDH-mut gliomas. Immunohistochemical loss of MMR proteins was not associated with survival, adjusting for clinically relevant confounders. …”
Publicado 2020
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3115“…Certain immunohistochemistry, FISH, or PCR-based molecular markers, including isocitrate dehydrogenase1/2 (IDH1/2) mutations, epidermal growth factor receptor variant III (EGFRvIII) mutation, vascular endothelial growth factor overexpression (VEGF) overexpression, or (O6-Methylguanine-DNA methyltransferase promoter) MGMT promoter methylation status, are well-described; however, their clinical usefulness and accuracy is limited, and tumor tissue samples are always necessary. …”
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3116por Thakkar, Jigisha, Teitcher, Michael, Anderson, Douglas, Barton, Kevin, Melain, Edward“…We present a case of a 33 year-old patient with glioblastoma (IDH wild type, MGMT unmethylated) who was diagnosed with COVID-19 pneumonia while undergoing chemotherapy. …”
Publicado 2020
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3117por Li, Deling, Patel, Chirag B., Xu, Guofan, Iagaru, Andrei, Zhu, Zhaohui, Zhang, Liwei, Cheng, Zhen“…However, most MI tracers are in preclinical development, with only integrin α(V)β(3) and isocitrate dehydrogenase (IDH)-mutant MI tracers having been translated to patients. …”
Publicado 2020
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3118“…RESULTS: Out of 11,764 study individuals, 88.03% (CI: 87.43–88.61) were normotensive and 11.97% (CI: 11.39–12.57) individuals were hypertensive. Prevalence of ISH, IDH and SDH were 241(2.05%), 403 (3.43%) and 764 (6.49%) respectively. …”
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