Mostrando 3,101 - 3,120 Resultados de 4,168 Para Buscar '"IDH"', tiempo de consulta: 0.16s Limitar resultados
  1. 3101
    “…There were no significant differences in seizure control in patients with/without IDH1 mutation and with/without MGMT methylation. …”
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  2. 3102
    “…Further we verify that D-2-hydroxyglutarate (D-2HG) is high in venous plasma from patients with isocitrate dehydrogenases1 (IDH1) mutations. Through these paired comparisons, we can exclude the interpatient variation that is present in plasma samples usually taken from the cubital vein.…”
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  3. 3103
  4. 3104
  5. 3105
    “…The proposed fully automated method was useful for predicting IDH mutations (sensitivity = 0.93, specificity = 0.88), ATRX mutations (sensitivity = 0.94, specificity = 0.92), chromosome 7/10 aneuploidies (sensitivity = 0.90, specificity = 0.88), and CDKN2 family mutations (sensitivity = 0.76, specificity = 0.86).…”
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  6. 3106
  7. 3107
  8. 3108
    “…AIM: To assess sonographic findings of the kidneys in hypertensive patients’ co-morbidities with type 2 diabetes mellitus and ischemic heart disease (IDH). MATERIALS AND METHODS: This was a prospective cross-sectional study involved 100 participants with primary hypertension selected by a method of simple convenient sampling. …”
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  9. 3109
    “…Specifically, DGCR5 expression was significantly decreased in GBM and IDH wild-type glioma. Gene ontology analysis showed that DGCR5 was predominantly enriched in immune-related biological processes. …”
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  10. 3110
    “…In addition, the glucose loading PET/CT was more useful than the fasting PET/CT for the discrimination of oligodendrogliomas from IDH-wildtype glioblastomas. Glucose loading resulted in a greater reduction in (18)F-FDG uptake in the normal cortex than in tumors, which increases the usefulness of (18)F-FDG PET/CT for grading.…”
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  11. 3111
    “…The understanding of the molecular landscape of BTC has offered hope of targeted therapies to the identified actionable genomic aberrations, such as FGFR2 gene fusions, mutations of IDH1/2, HER2, BRAC1/2 and BRAF. Pembigatinib has become the first approved targeted therapy for BTC with FGFR2 fusion or other rearrangements. …”
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  12. 3112
    “…CD73 expression was upregulated on immune cells by 2-hydroxyglutarate in IDH1 mutant glioma patients. In murine glioma models, adenosine receptor inhibitors demonstrated a modest therapeutic response; however, the addition of other inhibitors of the adenosine pathway did not further enhance this therapeutic effect. …”
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  13. 3113
    “…Knockout mutants of KGD2 and IDH2, which consume and generate alpha-ketoglutarate in mitochondria, exhibited increased and decreased resistance to fluconazole through a process that depended on Pdr1. …”
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  14. 3114
    “…Alteration of MMR protein expression was statistically more frequent in anaplastic gliomas, in recurrent disease, in patients treated with temozolomide, and in IDH-mut gliomas. Immunohistochemical loss of MMR proteins was not associated with survival, adjusting for clinically relevant confounders. …”
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  15. 3115
    “…Certain immunohistochemistry, FISH, or PCR-based molecular markers, including isocitrate dehydrogenase1/2 (IDH1/2) mutations, epidermal growth factor receptor variant III (EGFRvIII) mutation, vascular endothelial growth factor overexpression (VEGF) overexpression, or (O6-Methylguanine-DNA methyltransferase promoter) MGMT promoter methylation status, are well-described; however, their clinical usefulness and accuracy is limited, and tumor tissue samples are always necessary. …”
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  16. 3116
    “…We present a case of a 33 year-old patient with glioblastoma (IDH wild type, MGMT unmethylated) who was diagnosed with COVID-19 pneumonia while undergoing chemotherapy. …”
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  17. 3117
    “…However, most MI tracers are in preclinical development, with only integrin α(V)β(3) and isocitrate dehydrogenase (IDH)-mutant MI tracers having been translated to patients. …”
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  18. 3118
    “…RESULTS: Out of 11,764 study individuals, 88.03% (CI: 87.43–88.61) were normotensive and 11.97% (CI: 11.39–12.57) individuals were hypertensive. Prevalence of ISH, IDH and SDH were 241(2.05%), 403 (3.43%) and 764 (6.49%) respectively. …”
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  19. 3119
  20. 3120
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