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Mostrando 321 - 340 Resultados de 4,168 Para Buscar '"IDH"', tiempo de consulta: 0.17s Limitar resultados
  1. 321
    por Zou, Han, Li, Chang, Wanggou, Siyi, Li, Xuejun
    Publicado 2020
    “…We identified 12205 (20.18%), 6125 (10.13%) and 5206 (8.61%) genes associated with the overall survival (OS) of the IDH-wildtype, IDH-mutation 1p/19q intact and IDH-mutation 1p/19q codeletion gliomas, respectively. …”
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    Survival Risk Prediction Models of Gliomas Based on IDH and 1p/19q
  2. 322
    “…Because IDH1(R132H) requires a wild-type allele to produce (D)-2-hydroxyglutarate for epigenetic reprogramming, loss of IDH1(R132H) heterozygosity is associated with glioma progression in an IDH1-wildtype-like phenotype. …”
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    The neural stem-cell marker CD24 is specifically upregulated in IDH-mutant glioma
  3. 323
    por Sonego, Maura, Baldassarre, Gustavo
    Publicado 2020
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    A new role for IDH1 in the control of ovarian cancer cells metabolism and senescence
  4. 324
    “…However, little is known about the nutrient requirements of isocitrate dehydrogenase 1 (IDH1) mutant gliomas. The IDH1 mutation involves the acquisition of a neomorphic enzymatic activity which generates D-2-hydroxyglutarate from α-ketoglutarate. …”
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    Metabolic Landscape of a Genetically Engineered Mouse Model of IDH1 Mutant Glioma
  5. 325
    “…Mutations in isocitrate dehydrogenase 1 (IDH1mut) are reported in 70-90% of low-grade gliomas and secondary glioblastomas. …”
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    MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma
  6. 326
    “…One of the most significant of these changes has been the division of adult astrocytomas into IDH-wildtype and IDH-mutant categories in addition to histologic grade as part of the main-line diagnosis, although a great deal of heterogeneity in the clinical outcome still remains to be explained within these categories. …”
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    Beyond IDH-Mutation: Emerging Molecular Diagnostic and Prognostic Features in Adult Diffuse Gliomas
  7. 327
    “…Notably, ME1 interference ultimately resulted in adaptive upregulation of mitochondrial IDH2 dependent of AMPK-FoxO1 activation to replenish the NADPH pool and mitigate cytosolic ROS. …”
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    Cytosolic ME1 integrated with mitochondrial IDH2 supports tumor growth and metastasis
  8. 328
    “…Mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2) catalyzes the oxidative decarboxylation of isocitrate into α-ketoglutarate with concurrent reduction of NADP(+) to NADPH. …”
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    IDH2 Deficiency Is Critical in Myogenesis and Fatty Acid Metabolism in Mice Skeletal Muscle
  9. 329
    “…BACKGROUND: IDH-mutant lower-grade gliomas (LGGs) evolve under the selective pressure of therapy, but well-characterized patient-derived cells (PDCs) modeling evolutionary stages are lacking. …”
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    Patient-derived cells from recurrent tumors that model the evolution of IDH-mutant glioma
  10. 330
    “…Approximately 96% of patients with glioblastomas (GBM) have IDH1 wildtype GBMs, characterized by extremely poor prognosis, partly due to resistance to standard temozolomide treatment. …”
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    XGBoost Improves Classification of MGMT Promoter Methylation Status in IDH1 Wildtype Glioblastoma
  11. 331
    “…BACKGROUND: The prognosis of IDH1-mutant glioma is significantly better than that of wild-type glioma, and the preoperative identification of IDH mutations in glioma is essential for the formulation of surgical procedures and prognostic assessment. …”
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    The Value of Enhanced MR Radiomics in Estimating the IDH1 Genotype in High-Grade Gliomas
  12. 332
    “…Here we analyze the frequency of F3T3-fusion positivity, its associated genetic and methylation profiles, and its impact on survival in 906 IDH-wildtype GBM patients. We establish an F3T3 prevalence of 4.1% and delineate its associations with cancer signaling pathway alterations. …”
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    Genetic and epigenetic landscape of IDH-wildtype glioblastomas with FGFR3-TACC3 fusions
  13. 333
    “…IDH1 mutations occur in about 20–30% of gliomas and are a promising target for the treatment of cancer. …”
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    Discovery of Novel IDH1 Inhibitor Through Comparative Structure-Based Virtual Screening
  14. 334
    “…METHODS: We collected adult cases diagnosed with IDH-wildtype GBM and enrolled in Kansai Molecular Diagnosis Network for CNS Tumors (212 cases). …”
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    MPC-02 Prognostic effects of molecular factors in elderly patients with IDH-wildtype Glioblastomas
  15. 335
    “…BACKGROUND: Non-invasive diagnosis of IDH1 mutation for gliomas has great clinical significance, and PET has natural advantage to detect metabolism, as IDH mutated gliomas share lower glucose consumption. …”
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    The diagnostic value of lower glucose consumption for IDH1 mutated gliomas on FDG-PET
  16. 336
    “…METHODS: This study included 187 IDH-mutant glioblastomas and used 173 IDH-wildtype glioblastomas for comparison. …”
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    Predictive value of MGMT promoter methylation on the survival of TMZ treated IDH-mutant glioblastoma
  17. 337
    “…BACKGROUND: We aimed to determine whether plasma cell-free DNA (cfDNA) concentration is associated with survival in patients with isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM). METHODS: Pre-operative and post-chemoradiotherapy blood samples were prospectively collected from patients with newly diagnosed IDH wild-type GBM. …”
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    Association of plasma cell-free DNA with survival in patients with IDH wild-type glioblastoma
  18. 338
    “…Multiparametric images with 16-class clustering revealed the highest classification performance to differentiate IDH status with the AUC, accuracy, and F1-score of 0.81, 0.76, and 0.76, respectively. …”
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    Differentiating IDH status in human gliomas using machine learning and multiparametric MR/PET
  19. 339
    “…Westerns presented differential expression of SPHK1 and SPHK2 in IDH(WT) glioblastoma cells, while IDH(mut) exclusively expressed SPHK1. …”
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    DDRE-20. TARGETING SPHINGOLIPID PATHWAY REVEALS VULNERABILITY IN IDH1(MUT) GLIOMA
  20. 340
    “…Isocitrate dehydrogenase (IDH) mutations have been most commonly observed in glioma, but the involvement of mutant IDH in SCD1 expression also remains unknown. …”
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    BIMG-10. IDH1 MUTATIONS INDUCE ORGANELLE DEFECTS VIA DYSREGULATED PHOSPHOLIPIDS
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