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  1. 3541
    “…However, due to cost implications, we would recommend that efforts are focused on ways to target the highest scoring antigens, such as WT1, NRAS, IDH1 and TP53, although in the future other candidates may prove successful.…”
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    A Direct Comparison, and Prioritisation, of the Immunotherapeutic Targets Expressed by Adult and Paediatric Acute Myeloid Leukaemia Cells: A Systematic Review and Meta-Analysis
  2. 3542
    “…The aim of this exploratory study was to investigate whether tumor type is related to the spatial tractography pattern of the frontal aslant tract (FAT) in low-grade gliomas (LGGs). METHODS: In 64 IDH-mutated LGG patients, the FAT was generated using a pipeline for automatic tractography. …”
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    Oligodendrogliomas tend to infiltrate the frontal aslant tract, whereas astrocytomas tend to displace it
  3. 3543
    “…With exception of GAA, and 2-hydroxyglutarate in IDH-mutant gliomas, differences between non-enhancing tumour and brain microdialysate were modest and less consistent. …”
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    Blood-brain barrier disruption defines the extracellular metabolome of live human high-grade gliomas
  4. 3544
    “…This case illustrates the importance of considering DMG H3K27- altered glioma in adults older than 40 years who present with infiltrative IDH wildtype glioma in midline locations. Recognition of this diagnosis may allow enrollment in clinical trials and should prompt molecular testing for concurrent targetable alterations in the RAS-MAPK-pathway (e.g., mutations in BRAF V600E, FGFR1, NF1 and NTRK) and PI3K-mTOR pathway (e.g., PIK3CA mutation).…”
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    CEREBELLAR DIFFUSE MIDLINE GLIOMA, H3K27M ALTERED IN A FIFTY-FIVE-YEAR-OLD PATIENT
  5. 3545
    “…At the time of diagnosis, her karyotype was normal; however, FLT3-ITD, NPM1, DNMT3A, and IDH2 mutations were detected. She received induction therapy with daunorubicin and cytarabine and achieved hematological complete remission (HCR). …”
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    Gilteritinib Affects the Selection of Dominant Clones in Clonal Hematopoiesis: Sequential Genetic Analysis of an FLT3-ITD Positive AML Patient with Long-Term Gilteritinib Therapy
  6. 3546
    “…Moreover, the expression level of CDCA2 was significantly higher in glioma, and the level is correlated with grade, age, IDH1 mutation and 1p19q codeletion states. Further cell experimental results supported that the ability of cell proliferation, migration, invasion and radioresistance of glioma cells was significantly decreased after downregulated CDCA2 expression, and these changes may be achieved through the RAD51 and p21/CDK2/CyclinE1 signaling pathways. …”
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    SDPS-17 COMPREHENSIVE ANALYSIS OF CELL DIVISION CYCLE ASSOCIATED GENE FAMILY EXPRESSION PATTERN AND PROGNOSIS VALUE REVEALS CDCA2 AS A NOVEL ONCOGENE FOR GLIOMA
  7. 3547
    “…The majority of patients in the low-risk group had isocitrate dehydrogenase 1 (IDH1) mutations. The expression levels of these lncRNAs were significantly higher in glioblastoma cell lines than in normal cells. …”
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    Mutation-derived, genomic instability-associated lncRNAs are prognostic markers in gliomas
  8. 3548
    “…The high-risk group present poor prognosis with mutation of NPM1, TP53 (Multiple Hit) and FLT3(multiple hit), while IDH2 (Missense Mutation), MUC16 (Multiple Hit/Missense Mutation) occur mutation in low-risk group presenting favorite prognosis than high-risk group. …”
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    Identification and validation of a prognostic risk-scoring model based on the level of TIM-3 expression in acute myeloid leukemia
  9. 3549
    “…Astrocytoma and glioblastoma (GB) are reclassified subtypes of adult diffuse gliomas based on distinct isocitrate dehydrogenase (IDH) mutation in the fifth edition of the WHO Classification of Tumors of the Central Nervous System. …”
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    Distinct aneuploid evolution of astrocytoma and glioblastoma during recurrence
  10. 3550
    “…RNA sequencing (RNA-Seq) further shows that PTL decreased SLC25A1 expression at the mRNA level and that inhibition of SLC25A1 synergistically decreased the expression of IDH2 and several pivotal genes involved in mitochondrial respiratory chain complex, resulting in the production of ROS and mitochondrial dysfunction. …”
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    A novel SLC25A1 inhibitor, parthenolide, suppresses the growth and stemness of liver cancer stem cells with metabolic vulnerability
  11. 3551
    “…The CHCHD2 mRNA levels were increased in high-vs. low-grade glioma, IDH-wt GBMs, and in tumor vs. non-tumor tissue. …”
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    CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia-induced invasion and therapeutic resistance
  12. 3552
    “…According to trials providing patient’s detailed molecular diagnosis, we find that the effectiveness of OV treatment has no significant difference in patients with different IDH or MGMT status. CONCLUSIONS: Current clinical trials have initially shown the potential of oncolytic virotherapy as a new treatment for malignant glioma. …”
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    Clinical advances in oncolytic virus therapy for malignant glioma: a systematic review
  13. 3553
    “…Covariates included age, Karnofsky performance status, IDH1 mutation, and extent of resection. RESULTS: Median follow-up time and progression-free survival were 16 and 9 months, respectively. …”
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    Quantitative analysis of MGMT promoter methylation in glioblastoma suggests nonlinear prognostic effect
  14. 3554
    “…High BCL2A1 expression was associated with advanced WHO grade, IDH 1/2 wild type and the mesenchymal (ME) subtype, and its overexpression in glioma predicted resistance to temozolomide (TMZ) chemotherapy and unfavorable prognosis. …”
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    BCL2A1 is associated with tumor-associated macrophages and unfavorable prognosis in human gliomas
  15. 3555
    “…Here, we identify potential therapeutic targets and risk factors, including IDH1 p.R132S, high PD-L1 expression, and predominant macrophage infiltration, suggesting the potential benefits of combinational immune therapy and targeted therapy for SFTs. …”
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    Comprehensive analysis reveals potential therapeutic targets and an integrated risk stratification model for solitary fibrous tumors
  16. 3556
    “…This differential MRD reduction with GO2 varied across molecular subtypes, being greatest for IDH mutations. The 5-year overall survival (OS) was 29% for patients in the GO2 arm and 24% for those in the GO1 arm (hazard ratio [HR], 0.89; P = .14). …”
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    Fractionated vs single-dose gemtuzumab ozogamicin with determinants of benefit in older patients with AML: the UK NCRI AML18 trial
  17. 3557
    “…METHODS: From our methylome database of IDH (isocitrate dehydrogenase)-wildtype GB, we identified 158 non-GC and 65 GC cases. …”
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    Gliomatosis cerebri (GC) growth pattern: A single-center analysis of clinical, histological, and molecular characteristics of GC and non-GC glioblastoma
  18. 3558
    “…Mutational analysis of TET2, UTX, CBL, EZH2, ASXL1, TP53, RAS, IDH1/2, and DNMT-3A was performed on 21 of 41 patients, and revealed 13 mutations in 11 patients, but did not show any molecular markers of responsiveness to LEN. …”
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    Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide
  19. 3559
    “…Additionally, polymorphism and association analysis revealed that mutations in ATP5B, KRT8, PGM1, SLC22A7 and IDH1 genes could be potential markers for skatole levels in boars. …”
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    Identification of the Novel Candidate Genes and Variants in Boar Liver Tissues with Divergent Skatole Levels Using RNA Deep Sequencing
  20. 3560
    “…In rabbit ileal loop assays, the environmental isolates showed only 2-4 folds lesser fluid accumulation in comparison to N16961 and a V. cholerae clinical isolate IDH02365 of 2009. Pulsed Field Gel electrophoresis and Random amplification of Polymorphic DNA indicated that these isolates showed considerable diversity and did not share the same clonal lineage even though they were derived from the same water source. …”
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    Synergistic Effect of Various Virulence Factors Leading to High Toxicity of Environmental V. cholerae Non-O1/ Non-O139 Isolates Lacking ctx Gene : Comparative Study with Clinical Strains
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