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  1. 3761
    “…Molecular characterization of 23 PDX identified all of them as IDH-wt (R132) with frequent mutations in EGFR, TP53, FAT1, and within the PI3K/Akt/mTOR pathway. …”
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    Clinically relevant glioblastoma patient-derived xenograft models to guide drug development and identify molecular signatures
  2. 3762
    “…As for the detection of actionable mutations, 38% (n = 69) of patients had useful genetic mutation (FLT3‐ITD/TKD, IDH1/2, and DNMT3A (R822)) for treatment selection. …”
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    Clinical utility of genomic profiling of AML using paraffin‐embedded bone marrow clots: HM‐SCREEN‐Japan 01
  3. 3763
    “…GTR based on RTV improved median OS in the overall cohort (19.0 months, P < .0001), and in the subgroups with IDH wildtype tumors (18.5 months, P = .00055), MGMT methylated tumors (35.0 months, P < .0001), aged <70 (20.0 months, P < .0001), NIHSS 0–1 (19.0 months, P = .0038), KPS 90–100 (19.5 months, P = .0012), and KPS ≤80 (17.0 months, P = .036). …”
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    Impact of maximal extent of resection on postoperative deficits, patient functioning, and survival within clinically important glioblastoma subgroups
  4. 3764
    “…Further analysis showed TET2, NPM1, SRSF2, and IDH1 gene mutations, and epigenetic genes (p < 0.050) presented significantly higher frequency in older patients. …”
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    Gene mutation analysis using next‐generation sequencing and its clinical significance in patients with myeloid neoplasm: A multi‐center study from China
  5. 3765
    “…Additionally, EMT-related genes were upregulated in GBM archetypes (wild-type IDH1(R132) ) that historically have poorer treatment responses, with said genes being significant predictors of poorer survival in the TCGA cohort. …”
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    Identification of Prominent Genes between 3D Glioblastoma Models and Clinical Samples via GEO/TCGA/CGGA Data Analysis
  6. 3766
    “…From a population-based cohort of over 1800 pediatric and AYA (adolescent and young adult) gliomas, FGFR mutations were found in 6% of pediatric low-grade gliomas (LGG) and 16 % of IDH-WT AYA gliomas. Given the frequency of FGFR driver alterations, we assembled a large cohort of 370 FGFR mutated glioma across all ages (6 months to 87 years) 53% of which were LGG. …”
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    LGG-20. LANDSCAPE OF FGFR ALTERATIONS IN PEDIATRIC AND AYA GLIOMAS
  7. 3767
    “…Indeed, it was associated to a better prognosis in MAPK-induced tumors, but to a worse survival in IDH-wild-type glioblastomas. CDKN2A homozygous deletion present in all type of high grade pediatric or adult gliomas was significantly linked to a worse outcome in the entire population. …”
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    DIPG-33. P16 IMMUNOHISTOCHEMICAL EXPRESSION AS A SURROGATE ASSESSMENT OF CDKN2A ALTERATION IN GLIOMAS LEADING TO PROGNOSTIC SIGNIFICANCES
  8. 3768
    “…Categorical variables included sex (male vs female), genetic mutation status for 10 selected genes (BRAF, FGFR1, TSC1, TSC2, NF1, MYB, EGFR, ALK, IDH1, and RB1) that are known to play a role in the pathogenesis of pLGG (mutated vs non-mutated), and tumor location (9 categories). …”
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    LGG-19. MULTI-MODALITY CHARACTERIZATION OF PEDIATRIC LOW-GRADE GLIOMA: THE ADDED VALUE OF DIFFERENT DATA MODALITIES
  9. 3769
    “…Specific HOXAs could distinguish IDH mutation (HOXA1-7, HOXA9, HOXA13) and molecular GBM subtypes (HOXA1-2, HOXA9-11, HOXA13). …”
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    Development and validation of a predictive model in diagnosis and prognosis of primary glioblastoma patients based on Homeobox A family
  10. 3770
    “…Age, sex, MGMT methylation and IDH-mutation status were not associated with tumor dynamics during treatment. …”
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    PREDICTORS OF TUMOR DYNAMICS DURING A COURSE OF 30-FRACTION RADIOTHERAPY FOR GLIOBLASTOMA
  11. 3771
    “…The most common paediatric alterations included BRAF p.V600E (11%) and FGFR alterations (7%) while BRAF fusions (4%), H3 p.K27M (4%) and H3.3 p.G34R (1%) were rare. IDH mutation was found in 57% of tumours. Molecular GBM accounted for 7%. …”
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    THE CLINICAL AND MOLECULAR LANDSCAPE OF GLIOMAS IN ADOLESCENTS AND YOUNG ADULTS
  12. 3772
    “…Final pathological diagnosis including molecular diagnostics was consistent with WHO grade 4 IDH-wildtype H3G34 mutant diffuse hemispheric glioma with osseous metastases. …”
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    SDPS-08 OSSEOUS METASTASES IN H3G34-MUTANT DIFFUSE HEMISPHERIC GLIOMAS
  13. 3773
    “…Patients aged ≥65 years who underwent radiotherapy for IDH-wildtype eGBM between 2006 and 2021 were included. …”
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    LMAP-04 CHOOSING WISELY BETWEEN RADIOTHERAPY DOSE-FRACTIONATION SCHEDULES: THE MOLECULAR GRADED PROGNOSTIC ASSESSMENT (MOLGPA) FOR ELDERLY GLIOBLASTOMA (EGBM-MOLGPA)
  14. 3774
    “…In conclusion, the proposed four-gene (PTPN12, IDH2, P2RX4, and KDELR2) prognostic hazard model had satisfactory prognostic ability. …”
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    Identification of co-expressed gene networks promoting CD8(+) T cell infiltration and having prognostic value in uveal melanoma
  15. 3775
    “…According to Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses, ten genes (DGAT1, IDH2, CYP11B1, GFUS, CYC1, GPT, PYCR3, OPLAH, ALDH1A3, and NAPRT) associated with lactation fat percentage, milk yield, antioxidant activity, stress resistance, and inflammation and immune response were identified as key candidates for lactation traits. …”
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    Genome-Wide Association Study of Lactation Traits in Chinese Holstein Cows in Southern China
  16. 3776
    “…RESULTS: We studied 681 patients with first recurrence of Isocitrate Dehydrogenase (IDH) wild-type glioblastomas, including 310 patients who underwent re-resection. …”
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    Prognostic evaluation of re-resection for recurrent glioblastoma using the novel RANO classification for extent of resection: A report of the RANO resect group
  17. 3777
    “…METHODS: We retrospectively reviewed clinical and imaging data of 71 patients with newly diagnosed primary (IDH1 wildtype) mGBM who underwent operative treatment in 2015–2020 at the authors’ institution. …”
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    The role of cytoreductive surgery in multifocal/multicentric glioblastomas
  18. 3778
    “…To our knowledge, this study is the first to investigate the potential of conventional radiomics, sophisticated multi-resolution fractal texture features, and different molecular features (MGMT, IDH mutations) as a diagnostic and prognostic tool for prediction of REP from non-REP cases using computational and statistical modeling methods. …”
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    Prediction of Rapid Early Progression and Survival Risk with Pre-Radiation MRI in WHO Grade 4 Glioma Patients
  19. 3779
    “…Potential treatment targets were found in 31 patients (26%), most commonly ALK mutations/fusions (n = 4), RAS/RAF/MEK/ERK pathway mutations (n = 14), FGFR1 mutations/fusions (n = 5), IDH1 mutations (n = 2), and NTRK2 gene fusions (n = 2). …”
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    Diagnostic Yield From a Nationwide Implementation of Precision Medicine for all Children With Cancer
  20. 3780
    “…Hypertension phenotypes were categorized as normotension, pre-hypertension, isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and systolic-diastolic hypertension (SDH). …”
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    The associations of obesity phenotypes with the risk of hypertension and its transitions among middle-aged and older Chinese adults
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