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Mostrando 21 - 40 Resultados de 4,168 Para Buscar '"IDH"', tiempo de consulta: 0.23s Limitar resultados
  1. 21
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    Combination treatment of an IDH1 inhibitor with chemotherapy in IDH1 mutant acute myeloid leukemia
  2. 22
    por Zeng, Zhihong, Konopleva, Marina
    Publicado 2021
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    Concurrent inhibition of IDH and methyltransferase maximizes therapeutic efficacy in IDH mutant acute myeloid leukemia
  3. 23
    “…IDH-wildtype glioma and IDH-mutant glioma have different genetical and metabolic background although their histological appearances are similar. …”
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    CBMS-1 Targeting amino acid metabolic vulnerabilities in IDH-mutant and IDH-wildtype gliomas
  4. 24
    por Murugan, A. K., Alzahrani, A. S.
    Publicado 2022
    “…Background: There are isolated reports of mutations in genes for isocitrate dehydrogenases (IDH1 and IDH2), but few have been examined in a large number of different malignancies. …”
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    Isocitrate Dehydrogenase IDH1 and IDH2 Mutations in Human Cancer: Prognostic Implications for Gliomas
  5. 25
    “…This study aimed to find any ambiguous genetic outlier for “oligodendroglioma, IDH-mutant and 1p/19q-codeleted (O_IDH_mut)” and “astrocytoma, IDH-mutant (A_IDH_mut)” and to redefine the genetic landscape and prognostic factors of IDH-mutant gliomas. …”
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    Genomic profiles of IDH-mutant gliomas: MYCN-amplified IDH-mutant astrocytoma had the worst prognosis
  6. 26
    “…METHODS: The clinical, pathologic, and molecular features of 18 IDH-mutant astrocytomas and 20 IDH-wild-type glioblastomas with MMR mutations in the primary tumor were analyzed in comparison to 361 IDH-mutant and 906 IDH-wild-type tumors without MMR mutations. …”
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    Mismatch repair protein mutations in isocitrate dehydrogenase (IDH)-mutant astrocytoma and IDH-wild-type glioblastoma
  7. 27
    “…We assessed the effect of IDH1 (R132) mutations on IDH-mediated NADPH production in glioblastomas in situ. …”
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    The prognostic IDH1(R132) mutation is associated with reduced NADP(+)-dependent IDH activity in glioblastoma
  8. 28
    “…Isocitrate dehydrogenase 1 and 2 (IDH) mutations are frequently found in various cancer types such as gliomas, chondrosarcomas and myeloid malignancies. …”
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    Novel Multiplex Bead-Based Assay for Detection of IDH1 and IDH2 Mutations in Myeloid Malignancies
  9. 29
    “…Mutations in isocitrate dehydrogenase 1/2 (IDH1/2(MT)) are drivers of a variety of myeloid neoplasms. …”
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    CLINICAL AND BIOLOGICAL IMPLICATIONS OF ANCESTRAL AND NON-ANCESTRAL IDH1 AND IDH2 MUTATIONS IN MYELOID NEOPLASMS
  10. 30
    “…Mutated IDH1 (IDH1(MUT)) enzymes consume NADPH to produce d-2-hydroxyglutarate (d-2HG) resulting in the decreased reducing power needed for detoxification of reactive oxygen species (ROS), for example. …”
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    IDH1-mutant cancer cells are sensitive to cisplatin and an IDH1-mutant inhibitor counteracts this sensitivity
  11. 31
    por Wouters, Bas J.
    Publicado 2021
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    Targeting IDH1 and IDH2 Mutations in Acute Myeloid Leukemia: Emerging Options and Pending Questions
  12. 32
    “…Anaplastic lymphoma kinase (ALK), isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) and matrix metalloproteinase 8 (MMP8) gene mutations have been frequently reported in human cancers; however, to the best of our knowledge, they have not been specifically examined in differentiated thyroid cancers (DTCs). …”
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    Analysis of ALK, IDH1, IDH2 and MMP8 somatic mutations in differentiated thyroid cancers
  13. 33
    “…A subset of these gliomas contains mutations in isocitrate dehydrogenase 1 (IDH1(mut)) or, less commonly, IDH2 (together called “IDH(mut)”). …”
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    The efficacy of an unrestricted cycling ketogenic diet in preclinical models of IDH wild-type and IDH mutant glioma
  14. 34
    “…The G105G SNP (rs11554137) in the IDH1 gene is observed in about 10–15% of patients with a diffuse glioma. …”
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    Prognostic Analysis of the IDH1 G105G (rs11554137) SNP in IDH-Wildtype Glioblastoma
  15. 35
    “…SIMPLE SUMMARY: Chondrosarcomas are cartilage tumours that often harbour a mutation in one of the isocitrate dehydrogenase (IDH) genes. IDH mutations are important drivers at the beginning of cartilage tumour development, but their role in later stages remains unclear. …”
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    IDH Mutations in Chondrosarcoma: Case Closed or Not?
  16. 36
    “…More than 50% of patients with chondrosarcomas exhibit gain-of-function mutations in either isocitrate dehydrogenase 1 (IDH1) or IDH2. In this study, we performed genome-wide CpG methylation sequencing of chondrosarcoma biopsies and found that IDH mutations were associated with DNA hypermethylation at CpG islands but not other genomic regions. …”
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    Induction of sarcomas by mutant IDH2
  17. 37
    por Raineri, Silvia, Mellor, Jane
    Publicado 2018
    “…This is exemplified by the isoforms of isocitrate dehydrogenase (IDH1/2), which metabolize isocitrate to α-Ketoglutarate (α-KG). …”
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    IDH1: Linking Metabolism and Epigenetics
  18. 38
    por Platten, M., Bunse, L., Wick, W.
    Publicado 2021
    “…Isocitrate dehydrogenase (IDH)1 mutations, most frequently encoding for the neomorphic protein IDH1R132H, are frequent driver mutations found in the majority of diffuse World Health Organization grade 2 and 3 gliomas. …”
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    Emerging targets for anticancer vaccination: IDH
  19. 39
    “…Oligodendrogliomas are defined at the molecular level by the presence of an IDH mutation and codeletion of chromosomal arms 1p and 19q. …”
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    Oligosarcomas, IDH-mutant are distinct and aggressive
  20. 40
    “…PURPOSE: Isocitrate dehydrogenase (IDH) 1 and IDH2 mutations (IDH1/2mt) are frequent in glioma. …”
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    Multicenter Phase II Trial of the PARP Inhibitor Olaparib in Recurrent IDH1- and IDH2-mutant Glioma
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