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  1. 381
    “…Metabolic flexibility might be particularly constrained in tumors bearing mutations in isocitrate dehydrogenase 1 (IDH1) leading to the production of the oncometabolite 2-hydroxygluratate (2HG). …”
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    Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype
  2. 382
    “…Isocitrate dehydrogenases (IDH) convert isocitrate to alpha-ketoglutarate (α-KG). …”
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    D2HGDH regulates alpha-ketoglutarate levels and dioxygenase function by modulating IDH2
  3. 383
    “…Lu and colleagues demonstrated that expression of mutant forms of IDH1 or IDH2 caused global increases in histone methylation and increased levels of 2 hydroxyglutarate (Figure 1B). …”
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    Registered report: IDH mutation impairs histone demethylation and results in a block to cell differentiation
  4. 384
    “…BACKGROUND: The high frequency of mutations in the isocitrate dehydrogenase 1 (IDH1) gene in diffuse gliomas indicates its importance in the process of gliomagenesis. …”
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    IDH1(R132H) in Neural Stem Cells: Differentiation Impaired by Increased Apoptosis
  5. 385
    “…We used immunohistochemistry (IHC) to detect IDH1-R132H mutation and ATRX status and showed that the IDH1-R132H and (or) ATRX status could be necessary to provide the basic molecular information for the “integrated diagnosis” of gliomas. …”
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    Detection of ATRX and IDH1-R132H immunohistochemistry in the progression of 211 paired gliomas
  6. 386
    “…WHO(2007) grading of diffuse gliomas in adults is well-established. However, IDH mutations make classification of gliomas according to the WHO(2007) edition controversial. …”
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    IDH-1(R132H) mutation status in diffuse glioma patients: implications for classification
  7. 387
    “…Isocitrate dehydrogenase (IDH1) is an NADP-dependent enzyme that catalyzes the decarboxylation of isocitrate to alpha-ketoglutarate. …”
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    Decreased expression of IDH1-R132H correlates with poor survival in gastrointestinal cancer
  8. 388
    “…BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) mutation is common in low-grade glioma (approximately 80%) and acute myeloid leukemia (approximately 10%). …”
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    IDH1 R132C mutation is detected in clear cell hepatocellular carcinoma by pyrosequencing
  9. 389
    “…We have utilized a high-diversity phage display library to engineer antibody fragments (Fabs) that can modulate the activity of the enzyme isocitrate dehydrogenase 1 (IDH1). We show that a conformation-specific Fab can reactivate an IDH1 mutant associated with brain tumors. …”
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    Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody
  10. 390
    “…Isocitrate dehydrogenase (IDH) plays an indispensable role in the tricarboxylic acid cycle, and IDH mutations are present in nearly 75% of glioma and 20% of acute myeloid leukemia. …”
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    Structure based discovery of clomifene as a potent inhibitor of cancer-associated mutant IDH1
  11. 391
    “…In six model systems, including patient-derived stem cell-like glioblastoma cultures, inhibition of Bcl-xL induces significantly more apoptosis in IDH1-mutated cells than in wild-type IDH1 cells. …”
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    Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL
  12. 392
    “…Heterozygous mutations in NADP‐dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. …”
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    Altered metabolic landscape in IDH‐mutant gliomas affects phospholipid, energy, and oxidative stress pathways
  13. 393
    “…Isocitrate dehydrogenases 1 and 2 (IDH1,2), the key Krebs cycle enzymes that generate NADPH reducing equivalents, undergo heterozygous mutations in >70% of low- to mid-grade gliomas and ~20% of acute myeloid leukemias (AMLs) and gain an unusual new activity of reducing the α-ketoglutarate (α-KG) to D-2 hydroxyglutarate (D-2HG) in a NADPH-consuming reaction. …”
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    Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic Strategies
  14. 394
    “…To further investigate the role of IDH, we obtained methylation data of 777 samples from CGGA (Chinese Glioma Genome Atlas) and TCGA (The Cancer Genome Atlas) with IDH mutation status available. …”
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    MEGF10, a Glioma Survival-Associated Molecular Signature, Predicts IDH Mutation Status
  15. 395
    “…INTRODUCTION: The gene encoding isocitrate dehydrogenase 1 (IDH1) is frequently mutated in several tumor types including gliomas. …”
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    IDH1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis
  16. 396
    “…IDH‐mutant gliomas are classified into astrocytic or oligodendroglial tumors by 1p/19q status in the WHO 2016 classification, with the latter presenting with characteristic morphology and better prognosis in general. …”
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    IDH‐mutated astrocytomas with 19q‐loss constitute a subgroup that confers better prognosis
  17. 397
    “…CONCLUSION: IDH wild-type LGG vessels are molecularly distinct from the vasculature of IDH-mutated LGGs. …”
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    IDH mutation status is associated with distinct vascular gene expression signatures in lower-grade gliomas
  18. 398
    “…Previous studies uncovered mutations in IDH1 in several malignancies, with the most frequent mutation being IDH1 R132H. …”
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    IDH1 mutation promotes lung cancer cell proliferation through methylation of Fibulin-5
  19. 399
    “…The family of isocitrate dehydrogenase (IDH) enzymes is vital for cellular metabolism, as IDH1 and IDH2 are required for the decarboxylation of isocitrate to α-ketoglutarate. …”
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    Characterization of cancer-associated IDH2 mutations that differ in tumorigenicity, chemosensitivity and 2-hydroxyglutarate production
  20. 400
    “…In addition, we observed that low FREM2 expression was associated with progression of IDH-mutant low-grade glioma patients. Multivariate analysis showed positive association between FREM2 and favorable prognosis of IDH-wild type glioblastoma. …”
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    High FREM2 Gene and Protein Expression Are Associated with Favorable Prognosis of IDH-WT Glioblastomas
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