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Mostrando 421 - 440 Resultados de 4,168 Para Buscar '"IDH"', tiempo de consulta: 0.13s Limitar resultados
  1. 421
    “…BACKGROUND: Mutations in isocitrate dehydrogenase 1 or 2 (IDH1/2) define glioma subtypes and are considered primary events in gliomagenesis, impacting tumor epigenetics and metabolism. …”
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    Cystathionine-γ-lyase drives antioxidant defense in cysteine-restricted IDH1-mutant astrocytomas
  2. 422
    “…RESULTS: 267 patients with glioblastoma, IDH-wildtype (WHO grade IV) received surgery of whom 81 patients with residual tumor were included in the analysis. …”
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    Does positive MGMT methylation outbalance the limitation of subtotal resection in glioblastoma IDH-wildtype patients?
  3. 423
    “…In this prospective study, we correlated quantitative MRI data with histological features of 25 patients with isocitrate dehydrogenase (IDH) wild-type glioma. We found that the relative shortening of T1 relaxation time after the application of contrast agent was pronounced in the presence of tumor cells and vascular proliferates, indicating a disruption of the blood brain barrier (BBB). …”
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    Matching Quantitative MRI Parameters with Histological Features of Treatment-Naïve IDH Wild-Type Glioma
  4. 424
    por Murnyak, Balazs, Huang, L. Eric
    Publicado 2021
    “…Since the initial discovery of recurrent isocitrate dehydrogenase 1 (IDH1) mutations at Arg132 in glioma, IDH1 hotspot mutations have been identified in cholangiocarcinoma, chondrosarcoma, leukemia, and various other types of cancer of sporadic incidence. …”
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    Association of TP53 Alteration with Tissue Specificity and Patient Outcome of IDH1-Mutant Glioma
  5. 425
    “…Introduction: Prediction of IDH mutation status for Lower-grade glioma (LrGG) is clinically significant. …”
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    NI-12 The ratio of T1-Weighted to T2-Weighted Signal Intensity and IDH mutation in glioma
  6. 426
    “…Maffucci syndrome is a rare, highly variable somatic mosaic condition, and well-known cancer-related gain-of-function variants in either the IDH1 or IDH2 genes have been found in the affected tissues of most reported individuals. …”
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    Somatic IDH1 variant (p.R132C) in an adult male with Maffucci syndrome
  7. 427
    “…We showed that knockdown of IDH2 induced SDC2 expression in human umbilical vein endothelial cells (HUVECs). …”
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    Effect of Ulinastatin on Syndecan-2-Mediated Vascular Damage in IDH2-Deficient Endothelial Cells
  8. 428
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    Markedly prolonged disease course, with breakthrough seizures, in a glioma with an isolated IDH1 mutation
  9. 429
    por Huang, L. Eric
    Publicado 2022
    “…This new entity of IDH-mutant astrocytoma not only signifies an exception to the generally favorable outcome of IDH-mutant glioma, but also brings into question whether, and, if so, how, CDKN2A/B homozygous deletion overrides the anti-tumor activity of IDH mutation by promoting the proliferation of stem/neural progenitor-like cells. …”
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    Impact of CDKN2A/B Homozygous Deletion on the Prognosis and Biology of IDH-Mutant Glioma
  10. 430
    “…SIMPLE SUMMARY: Mutations of isocitrate dehydrogenase (IDH) genes are the distinctive genetic feature of lower-grade gliomas (LGGs). …”
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    Precision Oncology in Lower-Grade Gliomas: Promises and Pitfalls of Therapeutic Strategies Targeting IDH-Mutations
  11. 431
    “…Herein, the authors describe their experience of the potential benefit and clinical outcomes of using combination pembrolizumab (an immune checkpoint inhibitor) and laser interstitial thermal therapy in a case series of patients with recurrent IDH-wild-type glioblastoma.…”
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    Prolonged response of recurrent IDH-wild-type glioblastoma to laser interstitial thermal therapy with pembrolizumab
  12. 432
    “…IDH1 mutation has been reported in various tumors especially Cholangiocarcinoma, while the IDH1_R132H is reported to be the most common mutation of IDH1. …”
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    Computational study on novel natural compound inhibitor targeting IDH1_R132H
  13. 433
    por Sears, Thomas K., Woolard, Kevin D.
    Publicado 2022
    “…Considering the epigenetic dysregulation of IDH(mut) gliomas, we hypothesized that epigenetic-targeting drugs may yield therapeutic benefits in gliomas bearing IDH(mut). …”
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    R132H IDH1 sensitizes glioma to the antiproliferative and cytotoxic effects of BET inhibition
  14. 434
    “…RESULTS: Median age of AML patients was 39.5 years (18-75). ASXL1, IDH and CBL mutations were detected in 14 (20%), 10 (14%) and 5 (7%) patients, respectively. …”
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    High Frequency of ASXL1 and IDH Mutations in Young Acute Myeloid Leukemia Egyptian Patients
  15. 435
    “…For statistical analysis, Fisher’s exact test was used to assess associations between two variables, and the Mann-Whitney U test to compare the values between the IDH-wildtype and IDH-mutant groups. The optimal cut-off values of MET T/N ratio and MRS parameters for discriminating IDH-wildtype from IDH-mutant were obtained using receiver operating characteristics curves. …”
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    Radiological Prediction of Isocitrate Dehydrogenase (IDH) Mutational Status and Pathological Verification for Lower-Grade Astrocytomas
  16. 436
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    Corrigendum to: IDH knockdown alters foraging behavior in the termite Odontotermes formosanus in different social contexts
  17. 437
    “…PURPOSE: The role of temozolomide chemotherapy alone in isocitrate dehydrogenase (IDH)-mutant astrocytomas has not been conclusively determined. …”
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    Limited efficacy of temozolomide alone for astrocytoma, IDH-mutant, CNS WHO grades 2 or 3
  18. 438
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    Metabolic biomarkers of radiotherapy response in plasma and tissue of an IDH1 mutant astrocytoma mouse model
  19. 439
    “…The IDH2 inhibitor enasidenib was recently approved for IDH2-mutated relapsed or refractory AML. …”
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    Enasidenib as maintenance following allogeneic hematopoietic cell transplantation for IDH2-mutated myeloid malignancies
  20. 440
    “…This study was designed to determine whether MTAP status correlates with clinical outcome and uptake of 11C-methionine in astrocytoma with IDH mutations. METHODS: We conducted a MTAP immunohistochemistry staining of 30 IDH-mutant astrocytoma patients who underwent 11C-methionine positron emission tomography scans prior to surgical resection from 2000 to 2020. …”
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    NI-1 METHYLTHIOADENOSINE PHOSPHOLYLASE STATUS CORRELATES WITH PROGNOSIS AND METHIONINE UPTAKE IN IDH MUTANT ASTROCYTOMA
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