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481por Viswanath, Pavithra, Radoul, Marina, Izquierdo-Garcia, Jose Luis, Luchman, Hema Artee, Gregory Cairncross, J., Pieper, Russell O., Phillips, Joanna J., Ronen, Sabrina M.“…Unusually, however, PC and PE levels are reduced in mutant isocitrate dehydrogenase 1 (IDHmut) gliomas that produce the oncometabolite 2-hydroxyglutarate (2-HG) relative to wild-type IDH1 (IDHwt) gliomas. The goal of this study was to determine the molecular mechanism underlying this unusual metabolic reprogramming in IDHmut gliomas. …”
Publicado 2018
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482por Marosi, ChristineEnlace del recurso
Publicado 2018
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483por Li, Jiang‐jiang, Li, Ruilei, Wang, Wenxiang, Zhang, Baihua, Song, Xin, Zhang, Chunfang, Gao, Yang, Liao, Qianjin, He, Ya, You, Shuo, Tan, Zheqiong, Luo, Xiangjian, Li, Yueshuo, Tang, Min, Weng, Xinxian, Yi, Wei, Peng, Shifang, Liu, Shaohui, Tan, Ying, Bode, Ann M., Cao, Ya“…In our previous study, we found that IDH2 polymorphism rs11540478 is a risk factor for lung cancer. …”
Publicado 2018
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484por Zhang, Xinpei, Shi, Jinlong, Zhang, Jilei, Yang, Xinrui, Zhang, Gaoqi, Yang, Siyuan, Wang, Jing, Ke, Xiaoyan, Fu, Lin“…Another common gene involved in AML is IDH1/2. However, the influence of IDH1/2 mutations on outcomes in DNMT3A-mutated patients remains unknown. …”
Publicado 2018
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485por Oppermann, Henry, Dietterle, Johannes, Purcz, Katharina, Morawski, Markus, Eisenlöffel, Christian, Müller, Wolf, Meixensberger, Jürgen, Gaunitz, Frank“…METHODS: Cell viability of nine patient derived primary (isocitrate dehydrogenase wildtype; IDH1R132H non mutant) glioblastoma cell cultures and of eleven patient derived fibroblast cultures was determined by measuring ATP in cell lysates and dehydrogenase activity after incubation with 0, 50 or 75 mM carnosine for 48 h. …”
Publicado 2018
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486Persistent IDH1/2 mutations in remission can predict relapse in patients with acute myeloid leukemiapor Ok, Chi Young, Loghavi, Sanam, Sui, Dawen, Wei, Peng, Kanagal-Shamanna, Rashmi, Yin, C. Cameron, Zuo, Zhuang, Routbort, Mark J., Tang, Guilin, Tang, Zhenya, Jorgensen, Jeffrey L., Luthra, Rajyalakshmi, Ravandi, Farhad, Kantarjian, Hagop M., DiNardo, Courtney D., Medeiros, L. Jeffrey, Wang, Sa A., Patel, Keyur P.“…Persistence of IDH1 or IDH2 mutations in remission bone marrow specimens of patients with acute myeloid leukemia has been observed, but the clinical impact of these mutations is not well known. …”
Publicado 2019
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487por Yang, Hung-Chi, Yu, Hsiang, Liu, You-Cheng, Chen, Tzu-Ling, Stern, Arnold, Lo, Szecheng J., Chiu, Daniel Tsun-Yee“…Global metabolomic analysis was employed to address whether or not metabolic pathways were altered by severe NADPH insufficiency by the idh-1;gspd-1(RNAi) double-deficiency. The principal component analysis (PCA) points to a distinct metabolomic profile of idh-1;gspd-1(RNAi) double-deficiency. …”
Publicado 2019
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488por Falini, Brunangelo, Spinelli, Orietta, Meggendorfer, Manja, Martelli, Maria Paola, Bigerna, Barbara, Ascani, Stefano, Stein, Harald, Rambaldi, Alessandro, Haferlach, TorstenEnlace del recurso
Publicado 2019
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489por Kim, Geon-Hee, Choi, So Young, Oh, Taek-In, Kan, Sang-Yeon, Kang, Hyeji, Lee, Sujin, Oh, Taerim, Ko, Hyun Myung, Lim, Ji-Hong“…The R132H mutation in isocitrate dehydrogenase 1 (IDH1(R132H)) is commonly observed and associated with better survival in glioblastoma multiforme (GBM), a malignant brain tumor. …”
Publicado 2019
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490por Urbanovska, Irena, Megova, Magdalena Houdova, Dwight, Zachary, Kalita, Ondrej, Uvirova, Magdalena, Simova, Jarmila, Tuckova, Lucie, Buzrla, Petr, Palecek, Tomas, Hajduch, Marian, Dvorackova, Jana, Drabek, Jiri“…Mutations in IDH1/2 genes are a marker of good prognosis for glioma patients, associated with low grade gliomas and secondary glioblastomas. …”
Publicado 2018
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491por Chae, Unbin, Park, Jeen-Woo, Lee, Sang-Rae, Lee, Hong Jun, Lee, Hyun-Shik, Lee, Dong-Seok“…The results of this study suggest that Idh2 plays an important role in cellular senescence. …”
Publicado 2019
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492por Li, Kay Ka-Wai, Shi, Zhi-Feng, Malta, Tathiane M, Chan, Aden Ka-Yin, Cheng, Shaz, Kwan, Johnny Sheung Him, Yang, Rui Ryan, Poon, Wai Sang, Mao, Ying, Noushmehr, Houtan, Chen, Hong, Ng, Ho-Keung“…BACKGROUND: IDH-mutant glioblastoma is classified by the 2016 CNS WHO as a group with good prognosis. …”
Publicado 2019
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493por Sweta, Jajoriya, Khandelwal, Ravina, Srinitha, Sivaraj, Pancholi, Rashi, Adhikary, Ritu, Ali, Meer Asif, Nayarisseri, Anuraj, Vuree, Sugunakar, Singh, Sanjeev Kumar“…These drugs are identified as high potential IDH2 inhibitors and can halt AML when validated through further In vitro screening.…”
Publicado 2019
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494por Wang, Qi, Zhang, Lei, Cui, Yong, Zhang, Chi, Chen, Huairui, Gu, Juan, Qian, Jun, Luo, Chun“…Mutation of the isocitrate dehydrogenase (IDH) gene is regarded a novel indicator for the prognosis of patients with glioma. …”
Publicado 2020
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495por Berens, Michael E., Sood, Anup, Barnholtz-Sloan, Jill S., Graf, John F., Cho, Sanghee, Kim, Seungchan, Kiefer, Jeffrey, Byron, Sara A., Halperin, Rebecca F., Nasser, Sara, Adkins, Jonathan, Cuyugan, Lori, Devine, Karen, Ostrom, Quinn, Couce, Marta, Wolansky, Leo, McDonough, Elizabeth, Schyberg, Shannon, Dinn, Sean, Sloan, Andrew E., Prados, Michael, Phillips, Joanna J., Nelson, Sarah J., Liang, Winnie S., Al-Kofahi, Yousef, Rusu, Mirabela, Zavodszky, Maria I., Ginty, Fiona“…All features were compared between IDH mt and IDHwt patients and were finally combined to provide a holistic/integrated comparison. …”
Publicado 2019
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496Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Originpor Biedermann, Julia, Preussler, Matthias, Conde, Marina, Peitzsch, Mirko, Richter, Susan, Wiedemuth, Ralf, Abou-El-Ardat, Khalil, Krüger, Alexander, Meinhardt, Matthias, Schackert, Gabriele, Leenders, William P., Herold-Mende, Christel, Niclou, Simone P., Bjerkvig, Rolf, Eisenhofer, Graeme, Temme, Achim, Seifert, Michael, Kunz-Schughart, Leoni A., Schröck, Evelin, Klink, Barbara“…IDH1(R132H) (isocitrate dehydrogenase 1) mutations play a key role in the development of low-grade gliomas. …”
Publicado 2019
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497In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding sitepor Chaturvedi, Anuhar, Goparaju, Ramya, Gupta, Charu, Weder, Julia, Klünemann, Thomas, Araujo Cruz, Michelle Maria, Kloos, Arnold, Goerlich, Kerstin, Schottmann, Renate, Othman, Basem, Struys, Eduard A., Bähre, Heike, Grote-Koska, Denis, Brand, Korbinian, Ganser, Arnold, Preller, Matthias, Heuser, Michael“…Mutations in isocitrate dehydrogenase 1 (IDH1) are found in 6% of AML patients. Mutant IDH produces R-2-hydroxyglutarate (R2HG), which induces histone- and DNA-hypermethylation through inhibition of epigenetic regulators, thus linking metabolism to tumorigenesis. …”
Publicado 2019
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498Tumor mutational burden predicts survival in patients with low-grade gliomas expressing mutated IDH1por Alghamri, Mahmoud S, Thalla, Rohit, Avvari, Ruthvik P, Dabaja, Ali, Taher, Ayman, Zhao, Lili, Ulintz, Peter J, Castro, Maria G, Lowenstein, Pedro R“…Finally, we identified 6 gene sets that predict survival for LGG-mIDH-A and LGG-mIDH-O. CONCLUSIONS: we demonstrate that tumor mutational burden is a powerful, robust, and clinically relevant prognostic factor of MS in mIDH patients.…”
Publicado 2020
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499por Arita, Hideyuki, Ohno, Makoto, Nakamura, Taishi, Tanaka, Shota, Miyake, Yohei, Saito, Kuniaki, Tamura, Kaoru, Okita, Yoshiko, Fukai, Junya, Uda, Takehiro, Hata, Nobuhiro, Amura, Sabit, Kurozumi, Kazuhiko, Eriel, Sandika, Yamaguchi, Shigeru, Kanamori, Masayuki“…We investigated the value of prognostication incorporating TERT using the Japanese original cohort of 560 IDH-mutated adult gliomas. We collected the information of molecular status of IDH, TERT and 1p/19q and patient clinical data including Karnofsky performance status (KPS). …”
Publicado 2019
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500por Liu, Yang, Lu, Yanxin, Li, Aiguo, Celiku, Orieta, Han, Sue, Qian, Mingyu, Yang, Chunzhang“…Isocitrate dehydrogenase (IDH) mutations are common genetic abnormalities in lower grade gliomas. …”
Publicado 2020
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