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Mostrando 581 - 600 Resultados de 4,168 Para Buscar '"IDH"', tiempo de consulta: 0.20s Limitar resultados
  1. 581
    “…Recent characterization of spatiotemporal genomic architecture of IDH-wild-type multifocal glioblastomas (M-GBMs) suggests a clinically unobserved common-ancestor (CA) with a less aggressive phenotype, generating highly genetically divergent malignant gliomas/GBMs in distant brain regions. …”
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    Online Artículo Texto
    Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution
  2. 582
    “…At present, small-molecule inhibitors of IDH1 mutated enzyme are under investigation in preclinical and clinical phases as promising innovative treatments for IDH1-mutated intrahepatic cholangiocarcinomas. …”
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    Online Artículo Texto
    IDH1 Targeting as a New Potential Option for Intrahepatic Cholangiocarcinoma Treatment—Current State and Future Perspectives
  3. 583
    “…Methods: We investigated OS in a cohort of 44 patients diagnosed with wild type IDH glioblastoma (58.2 ± 11.4 years, 1.9/1 male/female) treated with neurosurgical resection followed by adjuvant chemo and radiotherapy. …”
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    Online Artículo Texto
    Assessment of Pre-operative Measurements of Tumor Size by MRI Methods as Survival Predictors in Wild Type IDH Glioblastoma
  4. 584
    “…Subsequently, the difference in median of the (23)Na concentration of this whole tumor area was compared between IDH-mutated and IDH wild-type gliomas as well as MGMT methylated and MGMT not-methylated glioblastomas using Whitney-Mann U-tests. …”
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    Online Artículo Texto
    Ultra-high-field sodium MRI as biomarker for tumor extent, grade and IDH mutation status in glioma patients
  5. 585
    “…Hierarchical molecular classification of IDH‐wildtype glioblastomas revealed 3 distinct groups of IDH‐wildtype glioblastomas. …”
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    Online Artículo Texto
    A tailored next‐generation sequencing panel identified distinct subtypes of wildtype IDH and TERT promoter glioblastomas
  6. 586
    “…One hundred and seventy IDH-wild-type GBM were screened for CT patterns using whole-genome single nucleotide polymorphism (SNP) arrays. …”
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    Online Artículo Texto
    RNA-sequencing of IDH-wild-type glioblastoma with chromothripsis identifies novel gene fusions with potential oncogenic properties
  7. 587
    “…Results: We observed that few immune cells infiltrate mutant IDH1/2 gliomas whereas the immune content of IDH1/2 wild-type tumors was more heterogeneous. …”
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    Online Artículo Texto
    Immune Profiling of Gliomas Reveals a Connection with IDH1/2 Mutations, Tau Function and the Vascular Phenotype
  8. 588
    “…Diffuse IDH-mutant astrocytoma mostly occurs in adults and carries a favorable prognosis compared to IDH-wildtype malignant gliomas. …”
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    Online Artículo Texto
    Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis
  9. 589
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    Impact of Inversion Time for FLAIR Acquisition on the T2-FLAIR Mismatch Detectability for IDH-Mutant, Non-CODEL Astrocytomas
  10. 590
    “…Report descriptions differed for IDH wild and mutant gliomas. Report features can be used to predict glioma IDH status.…”
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    Online Artículo Texto
    A Quantitative Assessment of Pre-Operative MRI Reports in Glioma Patients: Report Metrics and IDH Prediction Ability
  11. 591
    “…INTRODUCTION: Epileptic seizures in patients with low-grade, isocitrate dehydrogenase (IDH) mutated gliomas reach 90%, a major source of morbidity for these patients. …”
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    DDRE-27. IDH MUTATED GLIOMAS PROMOTE EPILEPTOGENESIS VIA D-2-HYDROXYGLUTARATE DEPENDENT MTOR HYPERACTIVATION
  12. 592
    “…Mutations in isocitrate dehydrogenase 1 or 2 (IDH1/2) define glioma subtypes and are considered primary events in gliomagenesis, impacting tumor epigenetics and metabolism. …”
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    FSMP-07. CYSTATHIONINE-Γ-LYASE DRIVES ANTIOXIDANT DEFENSE IN CYSTEINE-RESTRICTED IDH1 MUTANT ASTROCYTOMAS
  13. 593
    “…BACKGROUND: IDH1-mutated glioma is a recently defined disease entity with distinctive patterns of tumor cell biology, metabolism, and resistance to therapy. …”
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    DDRE-08. NRF2/GLUTATHIONE METABOLISM AS A NOVEL THERAPEUTIC TARGET FOR IDH1-MUTATED GLIOMA
  14. 594
    “…Phenotype experiment was carried out in the wild-type IDH1 and mutant IDH1(R132H) plasmid treated cell line. …”
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    Wild-type IDH1 inhibits the tumor growth through degrading HIF-α in renal cell carcinoma
  15. 595
    por Libura, Marta, Bialopiotrowicz, Emilia, Giebel, Sebastian, Wierzbowska, Agnieszka, Roboz, Gail J., Piatkowska-Jakubas, Beata, Pawelczyk, Marta, Gorniak, Patryk, Borg, Katarzyna, Wojtas, Magdalena, Florek, Izabella, Matiakowska, Karolina, Jazwiec, Bozena, Solarska, Iwona, Noyszewska-Kania, Monika, Piechna, Karolina, Zawada, Magdalena, Czekalska, Sylwia, Salamanczuk, Zoriana, Karabin, Karolina, Wasilewska, Katarzyna, Paluszewska, Monika, Urbanowska, Elzbieta, Gajkowska-Kulik, Justyna, Semenczuk, Grazyna, Rybka, Justyna, Wrobel, Tomasz, Ejduk, Anna, Kata, Dariusz, Grosicki, Sebastian, Robak, Tadeusz, Pluta, Agnieszka, Kominek, Agata, Piwocka, Katarzyna, Pyziak, Karolina, Sroka-Porada, Agnieszka, Wrobel, Anna, Przybylowicz, Agnieszka, Wojtaszewska, Marzena, Lewandowski, Krzysztof, Gil, Lidia, Piekarska, Agnieszka, Knopinska, Wanda, Bolkun, Lukasz, Warzocha, Krzysztof, Kuliczkowski, Kazimierz, Sacha, Tomasz, Basak, Grzegorz, Jedrzejczak, Wieslaw Wiktor, Holowiecki, Jerzy, Juszczynski, Przemysław, Haus, Olga
    Publicado 2021
    “…We assessed the prognostic significance of IDH1/2 mutations (IDH1/2(+)) in 398 AML patients with normal karyotype (NK-AML), treated with daunorubicine + cytarabine (DA), DA + cladribine (DAC), or DA + fludarabine. …”
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    IDH2 mutations in patients with normal karyotype AML predict favorable responses to daunorubicin, cytarabine and cladribine regimen
  16. 596
    “…METHODS: We analyzed the data of 100 adult patients (over 18 years old) with IDH‐wildtype GBM from our database between February 2006 and October 2018. …”
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    Clinical significance of CDKN2A homozygous deletion in combination with methylated MGMT status for IDH‐wildtype glioblastoma
  17. 597
    “…We show here that B7H3 expression is significantly decreased in IDH-mutated gliomas and in cultured IDH1-R132H glioma cells. …”
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    The Inhibition of B7H3 by 2-HG Accumulation Is Associated With Downregulation of VEGFA in IDH Mutated Gliomas
  18. 598
    “…Several studies have shown that 75% to 80% of secondary glioblastoma (GBM) showed IDH1 mutations, whereas only 5% of primary GBM have IDH1 mutations. …”
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    Opposed Interplay between IDH1 Mutations and the WNT/β-Catenin Pathway: Added Information for Glioma Classification
  19. 599
    “…However, the histomolecular heterogeneity in these series, mixing grade 3 with grade 4, and IDH-mutated with IDH-wildtype gliomas, represents a major selection bias that may influence survival analyses. …”
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    Feasibility, Safety and Impact on Overall Survival of Awake Resection for Newly Diagnosed Supratentorial IDH-Wildtype Glioblastomas in Adults
  20. 600
    “…[Image: see text] Human isocitrate dehydrogenase (IDH1) and its cancer-associated variant (IDH1 R132H) are rendered electroactive through coconfinement with a rapid NADP(H) recycling enzyme (ferredoxin-NADP(+) reductase) in nanopores formed within an indium tin oxide electrode. …”
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    Exploiting Electrode Nanoconfinement to Investigate the Catalytic Properties of Isocitrate Dehydrogenase (IDH1) and a Cancer-Associated Variant
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