Mostrando 621 - 640 Resultados de 4,168 Para Buscar '"IDH"', tiempo de consulta: 0.24s Limitar resultados
  1. 621
    “…In this study, to develop a feasible drug for IDH mutant glioma, we have investigated the changes of the lipid distribution and the mechanism of antineoplastic effect of SCD inhibition in IDH mutant glioma. …”
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  2. 622
    “…A histopathological diagnosis of glioblastoma was made in four patients and one of gliosarcoma in one patient. The initial status of IDH1, IDH2, H3F3A, HIST1H3B, and BRAF was “wild-type” in all patients. …”
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  3. 623
  4. 624
    “…Mitochondrial isocitrate dehydrogenase 2 (IDH2) is an important metabolic enzyme in the tricarboxylic acid cycle (TCA) cycle. …”
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  5. 625
    “…We aimed to analyze these modulations with 12 common driver genes in Isocitrate Dehydrogenase 1 wildtype glioblastomas (IDH1-W-GBs). Using Cbioportal, groups of tumor samples with and without DAs in these 12 genes were generated from the IDH1-W-GBs available from “The Cancer Genomics Atlas Firehose Legacy Study Group” (TCGA-FL-SG) on Glioblastomas (GBs). …”
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  6. 626
  7. 627
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  10. 630
    “…Mutations in isocitrate dehydrogenase (IDH) represent an independent predictor of better survival in patients with gliomas. …”
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  11. 631
  12. 632
    “…This is most evident by the significantly heightened seizure rate in patients with isocitrate dehydrogenase mutated (IDH(mut)) tumors compared to patients with IDH wildtype (IDH(wt)) gliomas. …”
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  13. 633
  14. 634
    “…Further, an empirical study revealed a significant genotype-by-environmental interaction (GxE) between Idh-1 genotype and temperature which affected fitness. …”
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  15. 635
    “…It has been reported that IDH1 (IDH1R132) mutation was a frequent genomic alteration in grade II and grade III glial tumors but rare in primary glioblastoma (pGBM). …”
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  16. 636
    “…All tumors and tumor components were analyzed for allelic loss of 1p/19q (LOH 1p/19q), for TP53- mutations and for R132 mutations in the IDH1 gene. The investigation of non- microdissected tumor tissue revealed clonality in 75% (38/51). …”
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  17. 637
    “…Monoallelic point mutations of the NADP(+)-dependent isocitrate dehydrogenases IDH1 and IDH2 occur frequently in gliomas, acute myeloid leukemias, and chondromas, and display robust association with specific DNA hypermethylation signatures. …”
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  18. 638
    “…Remarkably after nearly nine months, the tumor not only engrafted, but it also retained classic histological and genetic features of human oligodendroglioma, in particular cells with a clear cytoplasm, showing an infiltrative growth pattern, and harboring mutations of IDH1 (R132H) and of the tumor suppressor genes, FUBP1 and CIC. …”
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  19. 639
    “…Isocitrate dehydrogenase 1 (IDH1) gene mutations occur in ~ 60 – 90% of diffuse and anaplastic gliomas and secondary glioblastomas. …”
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  20. 640
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