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941por Sacli-Bilmez, Banu, Danyeli, Ayça Ersen, Yakicier, Cengiz, Pamir, M Necmettin, Özduman, Koray, Dincer, Alp, Ozturk-Isik, Esin“…Telomerase reverse transcriptase promoter (TERTp) mutations in the absence of IDH mutations (TERTp-only) are recently proposed as a characteristic of glioblastoma regardless of the morphological grade. …”
Publicado 2021
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942por Cai, Jia-Wei, Chen, Xiao-Yong, Chen, Jin-Yuan, Wu, Zan-Yi, Wu, Xi-Yue, Yu, Liang-Hong, You, Hong-HaiEnlace del recurso
Publicado 2021
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943por Maralani, Pejman Jabehdar, Myrehaug, Sten, Mehrabian, Hatef, Chan, Aimee KM, Wintermark, Max, Heyn, Chris, Conklin, John, Ellingson, Benjamin M., Rahimi, Saba, Lau, Angus Z, Tseng, Chia-Lin, Soliman, Hany, Detsky, Jay, Daghighi, Shadi, Keith, Julia, Munoz, David G., Das, Sunit, Atenafu, Eshetu G., Lipsman, Nir, Perry, James, Stanisz, Greg, Sahgal, Arjun“…The data were presented, analyzed, and described in the article, “Intravoxel incoherent motion (IVIM) modeling of diffusion MRI during chemoradiation predicts therapeutic response in IDH wildtype Glioblastoma”, published in Radiotherapy and Oncology [1].…”
Publicado 2021
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944por Kattih, Badder, Shirvani, Amir, Klement, Piroska, Garrido, Abel Martin, Gabdoulline, Razif, Liebich, Alessandro, Brandes, Maximilian, Chaturvedi, Anuhar, Seeger, Timon, Thol, Felicitas, Göhring, Gudrun, Schlegelberger, Brigitte, Geffers, Robert, John, David, Bavendiek, Udo, Bauersachs, Johann, Ganser, Arnold, Heineke, Joerg, Heuser, Michael“…Two recurrently mutated genes in CHIP and adult acute myeloid leukemia (AML) encode for isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2). Global expression of mutant IDH2 in transgenic mice-induced dilated cardiomyopathy and muscular dystrophy. …”
Publicado 2020
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945“…The objective of this study is to explore helpful imaging characteristics to refine RANO for assessing early treatment response (pseudoprogression and time-to-progression [TTP]) in patients with IDH wild-type glioblastoma. METHODS: This retrospective study enrolled 86 patients with IDH wild-type glioblastoma who underwent consecutive MRI examinations before and after concurrent chemoradiotherapy (CCRT). …”
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946por Seyfried, Thomas N., Shivane, Aditya G., Kalamian, Miriam, Maroon, Joseph C., Mukherjee, Purna, Zuccoli, Giulio“…The tumor cells were immunoreactive with antibodies to the IDH1 (R132H) mutation, P53 (patchy), MIB-1 index (4–6%), and absent ATRX protein expression. …”
Publicado 2021
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947“…His SM with associated clonal hematological non-mast cell lineage disease (SM-AHNMD) transformed to acute myelogenous leukemia with isocitrate dehydrogenase 2 (IDH2) mutation. A trial of enasidenib was given for 5 months but without any response. …”
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948por Deng, Maximilian Y., Sturm, Dominik, Pfaff, Elke, Sill, Martin, Stichel, Damian, Balasubramanian, Gnana Prakash, Tippelt, Stephan, Kramm, Christof, Donson, Andrew M., Green, Adam L., Jones, Chris, Schittenhelm, Jens, Ebinger, Martin, Schuhmann, Martin U., Jones, Barbara C., van Tilburg, Cornelis M., Wittmann, Andrea, Golanov, Andrey, Ryzhova, Marina, Ecker, Jonas, Milde, Till, Witt, Olaf, Sahm, Felix, Reuss, David, Sumerauer, David, Zamecnik, Josef, Korshunov, Andrey, von Deimling, Andreas, Pfister, Stefan M., Jones, David T. W.“…Our study reveals a unifying molecular signature for the majority of RIGs, with recurrent PDGFRA amplification and loss of CDKN2A/B and an absence of somatic hotspot mutations in genes encoding histone 3 variants or IDH1/2, uncovering diagnostic markers and potentially actionable targets.…”
Publicado 2021
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949por Zhu, Andrew X., Macarulla, Teresa, Javle, Milind M., Kelley, R. Kate, Lubner, Sam J., Adeva, Jorge, Cleary, James M., Catenacci, Daniel V. T., Borad, Mitesh J., Bridgewater, John A., Harris, William P., Murphy, Adrian G., Oh, Do-Youn, Whisenant, Jonathan R., Lowery, Maeve A., Goyal, Lipika, Shroff, Rachna T., El-Khoueiry, Anthony B., Chamberlain, Christina X., Aguado-Fraile, Elia, Choe, Sung, Wu, Bin, Liu, Hua, Gliser, Camelia, Pandya, Shuchi S., Valle, Juan W., Abou-Alfa, Ghassan K.“…IMPORTANCE: Isocitrate dehydrogenase 1 (IDH1) variations occur in up to approximately 20% of patients with intrahepatic cholangiocarcinoma. …”
Publicado 2021
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950por Beppu, Takaaki, Sato, Yuichi, Sasaki, Toshiaki, Terasaki, Kazunori, Iwaya, Takeshi, Ogasawara, Kuniaki“…Purpose: This study aimed to clarify whether positron emission tomography with (11)C-methyl-L-methionine ((11)C-met PET) can predict consequential outcomes at the time of discontinuing temozolomide (TMZ)-adjuvant chemotherapy in patients with residual isocitrate dehydrogenase gene (IDH)-mutant lower-grade glioma.Methods: In 30 patients showing residual lesions of IDH-mutant lower grade glioma (16 with diffuse astrocytoma and 14 with anaplastic astrocytoma), we performed (11)C-met PET, and calculated the tumor-to-normal brain tissue ratio of standardized uptake values (SUV(T/N)) at the time of discontinuing TMZ-adjuvant chemotherapy. …”
Publicado 2021
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951“…AIMS: To reveal the influence of hypoxia on tumor cells and immune cells in primary IDH-wt glioblastoma patients. METHODS: Single-cell RNA-seq data and bulk RNA-seq data were acquired from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases, respectively. …”
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952por Marker, Daniel F, Agnihotri, Sameer, Amankulor, Nduka, Murdoch, Geoffrey H, Pearce, Thomas M“…BACKGROUND: Infiltrative astrocytic tumors with and without isocitrate dehydrogenase (IDH) mutation frequently contain mutations in the TP53 tumor suppressor gene. …”
Publicado 2021
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953por Stadlbauer, Andreas, Heinz, Gertraud, Oberndorfer, Stefan, Zimmermann, Max, Kinfe, Thomas M., Buchfelder, Michael, Dörfler, Arnd, Kremenevski, Natalia, Marhold, Franz“…PURPOSE: This study aimed to determine the diagnostic performance of physiological MRI biomarkers including microvascular perfusion and architecture, neovascularization activity, tissue oxygen metabolism, and tension for recurrence detection of IDH-mutant WHO grade 3 glioma. METHODS: Sixty patients with IDH-mutant WHO grade 3 glioma who received overall 288 follow-up MRI examinations at 3 Tesla after standard treatment were retrospectively evaluated. …”
Publicado 2021
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954por Kikuchi, Kazufumi, Togao, Osamu, Yamashita, Koji, Momosaka, Daichi, Kikuchi, Yoshitomo, Kuga, Daisuke, Hata, Nobuhiro, Mizoguchi, Masahiro, Yamamoto, Hidetaka, Iwaki, Toru, Hiwatashi, Akio, Ishigami, Kousei“…Between May 2019 and May 2020, thirteen patients with IDH-mutant diffuse gliomas, including seven with astrocytomas and six with oligodendrogliomas, were evaluated. …”
Publicado 2022
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955por Bumes, Elisabeth, Fellner, Claudia, Fellner, Franz A., Fleischanderl, Karin, Häckl, Martina, Lenz, Stefan, Linker, Ralf, Mirus, Tim, Oefner, Peter J., Paar, Christian, Proescholdt, Martin Andreas, Riemenschneider, Markus J., Rosengarth, Katharina, Weis, Serge, Wendl, Christina, Wimmer, Sibylle, Hau, Peter, Gronwald, Wolfram, Hutterer, Markus“…SIMPLE SUMMARY: The enzyme isocitrate dehydrogenase (IDH) affects glioma cell metabolism in multiple ways. …”
Publicado 2022
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956por Ieni, Antonio, Pizzimenti, Cristina, Broggi, Giuseppe, Caltabiano, Rosario, Germanò, Antonino, Barbagallo, Giuseppe Maria Vincenzo, Vigneri, Paolo, Giuffrè, Giuseppe, Tuccari, Giovanni“…In the present pilot study, the immunohistochemical pattern of p62 was analyzed in a cohort of patients with isocitrate dehydrogenase (IDH)1/2 wild-type glioblastoma (GBM), in primary and recurrent samples, in order to verify the concordance or discordance between the primary and recurrent tumors. …”
Publicado 2022
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957por Garcia Vicente, Ana María, Pérez-Beteta, Julián, Amo-Salas, Mariano, Bosque, Jesús J., Noriega-Álvarez, Edel, Soriano Castrejon, Ángel María, Pérez-García, Víctor M.“…(1) Aim: To study the associations between imaging parameters derived from contrast-enhanced MRI (CE-MRI) and (18)F-fluorocholine PET/CT and their performance as prognostic predictors in isocitrate dehydrogenase wild-type (IDH-wt) high-grade gliomas. (2) Methods: A prospective, multicenter study (FuMeGA: Functional and Metabolic Glioma Analysis) including patients with baseline CE-MRI and (18)F-fluorocholine PET/CT and IDH wild-type high-grade gliomas. …”
Publicado 2022
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958por Montégut, Coline, Guillamo, Jean-Sébastien, Ducray, François, Dehais, Caroline, Cohen-Jonathan Moyal, Elisabeth, Desenclos, Christine, Petit, Antoine, Seizeur, Romuald, Bekaert, Lien, Gaultier, Claude, Motuo Fotso, Marie Jeannette, Blonski, Marie, Frenel, Jean-Sébastien, Vauléon, Elodie, Langlois, Olivier, Noel, Georges, Carpentier, Antoine F., Di Stefano, Anna Luisa, Bronnimann, Charlotte, Figarella-Branger, Dominique, Chinot, Olivier, Tabouret, Emeline“…Although they are classified based on the IDH mutation status very little is known considering this alteration in the elderly glioma population. …”
Publicado 2022
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959por Krigers, Aleksandrs, Klingenschmid, Julia, Cosar, Tolga, Moser, Patrizia, Thomé, Claudius, Freyschlag, Christian F.“…We investigated how progression-free survival (PFS) and overall survival (OS) in older patients with IDH wild-type glioblastoma were influenced by concomitant radio-chemotherapy and MGMT promotor methylation status in real-life settings. …”
Publicado 2022
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960por Gulaia, Valeriia, Shmelev, Mikhail, Romanishin, Aleksander, Shved, Nikita, Farniev, Vladislav, Goncharov, Nikolay, Biktimirov, Arthur, Vargas, Irene Lisa, Khodosevich, Konstantin, Kagansky, Alexander, Kumeiko, VadimEnlace del recurso
Publicado 2023
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