Materias dentro de su búsqueda.
Mostrando 81 - 100 Resultados de 4,168 Para Buscar '"IDH"', tiempo de consulta: 1.72s Limitar resultados
  1. 81
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    IDH1 mutations in a Brazilian series of Glioblastoma
  2. 82
    “…Almost all described mutations are heterozygous missense mutations affecting a conserved arginine residue in the substrate binding site of IDH1 (R132) or IDH2 (R172). But the exact mechanism of IDH mutations in neoplasia is not understood. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Promoter Methylation Analysis of IDH Genes in Human Gliomas
  3. 83
    “…We found that the distribution of IDH1(R132H), IDH1(nonR132H), and IDH2 mutations differed between astrocytic, mixed, and oligodendroglial tumors, with an overrepresentation of IDH2 mutations in oligodendroglial phenotype and an overrepresentation of IDH1(nonR132H) in astrocytic tumors. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    IDH Mutations: Genotype-Phenotype Correlation and Prognostic Impact
  4. 84
    “…BACKGROUND: Mutations in isocitrate dehydrogenase (IDH) 1 have been reported in over 70% of low-grade gliomas and secondary glioblastomas. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Metabolic Reprogramming in Mutant IDH1 Glioma Cells
  5. 85
    “…RESULTS: We identified four cases of ESFTs harboring IDH mutations. The number of IDH1 and IDH2 mutations was equal and the subtype of IDH mutations was variable. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    IDH Mutation Analysis in Ewing Sarcoma Family Tumors
  6. 86
    “…Most notably, cytosolic IDH1 is mutated in 70–90% of low-grade gliomas and upgraded glioblastomas, and mitochondrial IDH2 is mutated in ~20% of acute myeloid leukemia cases. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells
  7. 87
    “…Gain-of-function IDH mutations are initiating events that define major clinical and prognostic classes of gliomas(1,2). …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Insulator dysfunction and oncogene activation in IDH mutant gliomas
  8. 88
    por Saeed, Mohammed Sami
    Publicado 2015
    “…OBJECTIVE: To assess the frequency of IDH1 mutations in gliomas and to correlate the IDH1 positivity with the type and grade of tumors, the age and sex of the patients. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    IDH1 Mutation in Gliomas in Mosul City - Iraq
  9. 89
    “…BACKGROUND: This study evaluates the presence of R132H mutation in isocitrate dehydrogenase (IDH1) gene and the vascular endothelial growth factor (VEGF) +936 C/T polymorphism in brain tumors. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Genetic alterations of IDH1 and Vegf in brain tumors
  10. 90
    “…Isocitrate dehydrogenase 1 (IDH1) is the most commonly mutated gene in grade II–III glioma and secondary glioblastoma (GBM). …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Mutant IDH1 Promotes Glioma Formation In Vivo
  11. 91
    por Park, Jong-Whi, Turcan, Şevin
    Publicado 2019
    “…Nearly 80% of the lower-grade gliomas and secondary glioblastomas harbor recurrent mutations in isocitrate dehydrogenase (IDH). Mutant IDH generates high levels of 2-hydroxyglutarate (2-HG) that inhibit various components of the epigenetic machinery, including histone and DNA demethylases. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Epigenetic Reprogramming for Targeting IDH-Mutant Malignant Gliomas
  12. 92
    “…The multitargeted activity of these compounds makes them valuable agents against a wide range of cancers, regardless of the status of IDH1.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    The Landscape of the Anti-Kinase Activity of the IDH1 Inhibitors
  13. 93
    “…BACKGROUND: Many low-grade gliomas (LGG) harbor isocitrate dehydrogenase (IDH) mutations. Although IDH mutation is known to be epileptogenic, the rate of refractory seizures in LGG with IDH mutation vs wild-type had not been previously compared. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Pharmacoresistant seizures and IDH mutation in low-grade gliomas
  14. 94
    “…We report a case of adult BSG with isocitrate dehydrogenase (IDH) mutation. A 43-year-old male was admitted to our hospital with diplopia and right-sided hypesthesia. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Malignant Progression of an IDH Mutant Brainstem Glioma in Adult
  15. 95
    “…We also discuss the role of IDH1/2 mutations as biomarkers and drug targets. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    IDH1/2 mutations in acute myeloid leukemia
  16. 96
    “…Recent advances in FLT3 and IDH targeted inhibition have improved response rates and overall survival in patients with mutations affecting these respective proteins. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Resistance to targeted therapies: delving into FLT3 and IDH
  17. 97
    “…Among the most common, IDH mutations, EGFR amplification, mutation, PTEN loss, and MGMT promoter mutation have emerged as key patterns associated with upregulated glycolysis and OXPHOS glutamine addiction and altered lipid metabolism in GBM. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Metabolic Rewiring in Glioblastoma Cancer: EGFR, IDH and Beyond
  18. 98
    “…Since the advent of molecular diagnostics, more homogenous sub-entities have emerged, including the isocitrate dehydrogenase-mutated (IDH-mutated) astrocytomas and 1p19q-codeleted oligodendrogliomas. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Seizures in patients with IDH-mutated lower grade gliomas
  19. 99
    “…In this issue, Bader et al.(1) characterize the proteomes of diffuse glioma brain tumors by liquid chromatography mass spectrometry and classify isocitrate dehydrogenase (IDH)-mutant gliomas into two subtypes, which differ in oncogenic pathways and aerobic/anaerobic energy metabolism.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    Proteome-based insights for IDH-mutant glioma classification
  20. 100
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Rosette-forming glioneuronal tumor: a pineal region case with IDH1 and IDH2 mutation analyses and literature review of 43 cases
Herramientas de búsqueda: RSS