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  1. 1121
    por Wang, Peng, Lv, Changqi, Zhu, Guoping
    Publicado 2015
    “…However, no NAD(+)-specific IDHs have been found among type II IDHs and monomeric IDHs. …”
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    Novel Type II and Monomeric NAD(+) Specific Isocitrate Dehydrogenases: Phylogenetic Affinity, Enzymatic Characterization, and Evolutionary Implication
  2. 1122
    “…Isocitrate dehydrogenase (IDH), a housekeeping gene, has drawn the attention of cancer experts. …”
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    Online Artículo Texto
    Single Arginine Mutation in Two Yeast Isocitrate Dehydrogenases: Biochemical Characterization and Functional Implication
  3. 1123
    “…Idh2 gene-deleted (Idh2(−/−)) male mice and wild-type (Idh2(+/+)) littermates were fed either HFD or low-fat diet (LFD). …”
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    Online Artículo Texto
    Isocitrate dehydrogenase 2 deficiency aggravates prolonged high-fat diet intake-induced hypertension
  4. 1124
    “…Variants of isocitrate dehydrogenase (IDH) 1 and 2 (IDH1/2) alter metabolism in cancer cells by catalyzing the NADPH-dependent reduction of 2-oxoglutarate (2OG) to (2R)-hydroxyglutarate. …”
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    Online Artículo Texto
    Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2
  5. 1125
    “…BACKGROUND: Gliomas frequently contain mutations in the cytoplasmic NADP(+)-dependent isocitrate dehydrogenase (IDH1) or the mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDH2). …”
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    2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP(+)-Dependent Isocitrate Dehydrogenase Mutations
  6. 1126
    “…Herein, we report TQ05310 as the first mutant IDH2 inhibitor that potently targets both IDH2‐R140Q and IDH2‐R172K mutants. …”
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    Online Artículo Texto
    Pharmacological characterization of TQ05310, a potent inhibitor of isocitrate dehydrogenase 2 R140Q and R172K mutants
  7. 1127
    “…Cisplatin-induced renal functional and morphological impairments were greater in Idh2(−/−) mice than in Idh2(+/+) mice. Mito-T mitigated those impairments in both Idh2(−/−) and Idh2(+/+) mice and this mitigation was greater in Idh2(−/−) than in Idh2(+/+) mice. …”
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    Mitochondrial NADP(+)-dependent isocitrate dehydrogenase deficiency increases cisplatin-induced oxidative damage in the kidney tubule cells
  8. 1128
    “…Purpose and background: Isocitrate dehydrogenase (IDH) mutation and O-6 methyl guanine methyl transferase (MGMT) methylation are surrogate biomarkers of improved survival in gliomas. …”
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    Multiparametric Magnetic Resonance Imaging Correlates of Isocitrate Dehydrogenase Mutation in WHO high-Grade Astrocytomas
  9. 1129
    “…Aim: Isocitrate dehydrogenase 1 (IDH1) is key enzyme involved in cellular metabolism and DNA repair. …”
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    Online Artículo Texto
    Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism
  10. 1130
    por Liu, Xiaoyan, Gong, Yuping
    Publicado 2019
    “…IDH mutation occurs in 20% of acute myeloid leukemia (AML) patients, mainly including IDH1 R132, IDH2 R140, and IDH2 R172. …”
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    Online Artículo Texto
    Isocitrate dehydrogenase inhibitors in acute myeloid leukemia
  11. 1131
    “…Mutations in the genes encoding isocitrate dehydrogenase, IDH1 and IDH2, have been reported in gliomas, myeloid leukemias, chondrosarcomas, and thyroid cancer. …”
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    Mutations in Isocitrate Dehydrogenase 1 and 2 Occur Frequently in Intrahepatic Cholangiocarcinomas and Share Hypermethylation Targets with Glioblastomas
  12. 1132
    “…We have solved two crystal structures of the thermophilic Clostridium thermocellum IDH (CtIDH), a native open apo CtIDH to 2.35 Å and a quaternary complex of CtIDH with NADP(+), isocitrate and Mg(2+) to 2.5 Å. …”
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    The complex structures of isocitrate dehydrogenase from Clostridium thermocellum and Desulfotalea psychrophila suggest a new active site locking mechanism
  13. 1133
    “…The IDH mutations are remarkably specific to arginine 132 (R132) in IDH1 and arginine 172 (R172) or arginine 140 (R140) in IDH2; IDH1/2 mutations are known to convert α-ketoglutarate to oncometabolite R(-)-2-hydroxyglutarate. …”
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    Online Artículo Texto
    Isocitrate dehydrogenase mutation is frequently observed in giant cell tumor of bone
  14. 1134
    “…BACKGROUND: Mutations in the isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes are frequent molecular lesions in acute myeloid leukaemia with normal karyotype (AML-NK). …”
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    Somatic mutations of isocitrate dehydrogenases 1 and 2 are prognostic and follow-up markers in patients with acute myeloid leukaemia with normal karyotype
  15. 1135
    “…Rare cases of adulthood IDH have been reported and no study until now aimed to compare juvenile and adulthood IDH. …”
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    Online Artículo Texto
    Clinicopathological aspects and proviral load of adulthood infective dermatitis associated with HTLV-1: Comparison between juvenile and adulthood forms
  16. 1136
    “…Based on cofactor usage, IDHs are either NAD(+)-specific (NAD-IDH) or NADP(+)-specific (NADP-IDH); NADP-IDH evolved from NAD-IDH. …”
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    A Novel Type II NAD(+)-Specific Isocitrate Dehydrogenase from the Marine Bacterium Congregibacter litoralis KT71
  17. 1137
    “…Factors associated with IDH were evaluated and compared with cohort without IDH. …”
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    Online Artículo Texto
    Intradialytic Hypertension Increases Non-access Related Hospitalization and Mortality in Maintenance Hemodialysis Patients
  18. 1138
    “…Isocitrate dehydrogenases (IDHs) are a class of key proteins in energy metabolism, including IDH1, IDH2, and IDH3, which are involved in the oxidative decarboxylation of isocitrate to yield α-ketoglutarate (α-KG). …”
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    The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer
  19. 1139
    “…Intradialytic hypotension (IDH) is a common complication of hemodialysis, but there is no data about the time of onset during treatment. …”
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    The time of onset of intradialytic hypotension during a hemodialysis session associates with clinical parameters and mortality
  20. 1140
    “…BACKGROUND: Mutations in the isocitrate dehydrogenase 1 (IDH1) and IDH2 genes are important for both the integrated diagnosis and the prognosis of diffuse gliomas. …”
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    Clinico-neuropathological features of isocitrate dehydrogenase 2 gene mutations in lower-grade gliomas
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