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  1. 1141
    “…Although IDHs are widely distributed in bacteria, archaea, and eukaryotes, all type III IDHs reported to date are found only in prokaryotes. …”
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    Online Artículo Texto
    Biochemical and Phylogenetic Characterization of a Novel NADP(+)-Specific Isocitrate Dehydrogenase From the Marine Microalga Phaeodactylum tricornutum
  2. 1142
    “…Genetic analyses showed that IDH genes (IDH1, IDH2, IDH3A, IDH3B) and ACO genes (ACO1, ACO2) were not associated with BD. …”
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    Online Artículo Texto
    Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis
  3. 1143
    “…The prognostic significance of mutant IDH (mIDH) is controversial but appears to be influenced by co-mutational status and the specific location of the mutation (IDH1-R132, IDH2-R140, IDH2-R172). …”
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    Online Artículo Texto
    Isocitrate dehydrogenase mutations in myeloid malignancies
  4. 1144
    por OHBA, Shigeo, HIROSE, Yuichi
    Publicado 2016
    “…The mutations often occur in grade 2 or 3 gliomas and secondary glioblastomas. Most IDH mutations are associated with codon 132 and 172 in IDH1 and IDH2 in gliomas, respectively. …”
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    Online Artículo Texto
    Biological Significance of Mutant Isocitrate Dehydrogenase 1 and 2 in Gliomagenesis
  5. 1145
    “…Here, we generated Idh3b-KO mice and found that IDH3B is essential for IDH3 activity in multiple tissues. …”
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    Online Artículo Texto
    Isocitrate dehydrogenase 3b is required for spermiogenesis but dispensable for retinal viability
  6. 1146
    “…Somatic mutations of isocitrate dehydrogenase (IDH) 1 and IDH2 occur in gliomas, acute myeloid leukemia, and cartilaginous tumors. …”
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    Online Artículo Texto
    Isocitrate dehydrogenase 2 mutation is a frequent event in osteosarcoma detected by a multi-specific monoclonal antibody MsMab-1
  7. 1147
    “…METHODS: We have purified recombinant IDH1 and IDH1-R132H proteins and monitored their catalytic activities. …”
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    Online Artículo Texto
    Identification of a New Selective Chemical Inhibitor of Mutant Isocitrate Dehydrogenase-1
  8. 1148
    “…BACKGROUND: Intradialytic-hypotension (IDH) is a common complication of hemodialysis. High ultrafiltration rate (UFR) might lead to IDH. …”
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    Online Artículo Texto
    High ultrafiltration rate induced intradialytic hypotension is a predictor for cardiac remodeling: a 5-year cohort study
  9. 1149
    “…Objective: Mitochondrial NADP+-dependent isocitrate dehydrogenase 2 (IDH2) is a major producer of mitochondrial NADPH. …”
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    Online Artículo Texto
    Functional analysis and clinical significance of the isocitrate dehydrogenase 2 gene in papillary thyroid carcinoma
  10. 1150
    “…Isocitrate dehydrogenase (IDH) is a key enzyme in normal metabolism and homeostasis. …”
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    Online Artículo Texto
    Isocitrate dehydrogenase mutations in gliomas: A review of current understanding and trials
  11. 1151
    “…To investigate if broad metabolic aberrations may result from IDH1 and IDH2 mutations in AML, plasma metabolomics was conducted by gas chromatography–mass spectrometry (GC–MS) on 51 AML patients, 29 IDH1/2 wild-type (WT), 9 with IDH1R132, 12 with IDH2R140 and one with IDH2R172 mutations. …”
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    Online Artículo Texto
    (2R,3S)-Dihydroxybutanoic Acid Synthesis as a Novel Metabolic Function of Mutant Isocitrate Dehydrogenase 1 and 2 in Acute Myeloid Leukemia
  12. 1152
    “…We report binding and inhibition studies on 13 IDH1/2 variant inhibitors, including clinical candidates and drugs, with wild-type (wt) IDH1 and its cancer-associated variant, IDH1 R132H. …”
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    Online Artículo Texto
    Differentiating Inhibition Selectivity and Binding Affinity of Isocitrate Dehydrogenase 1 Variant Inhibitors
  13. 1153
    “…BACKGROUND: Intra-dialytic hypertension (IDH) is emerging as an important issue in hemodialysis patients. …”
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    Online Artículo Texto
    Intra-dialytic hypertension is associated with high mortality in hemodialysis patients
  14. 1154
    “…Isocitrate dehydrogenase (IDH) can be divided into NAD(+)-dependent and NADP(+)-dependent types based on the coenzyme specificity. …”
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    Enzymatic Characterization of the Isocitrate Dehydrogenase with Dual Coenzyme Specificity from the Marine Bacterium Umbonibacter marinipuiceus
  15. 1155
    “…The present study detected isocitrate dehydrogenase (IDH) 1 and IDH2 mutations in glioma to analyze whether IDH-mutated gliomas are situated in certain preferential areas and to investigate their correlation with magnetic resonance imaging (MRI) characteristics. …”
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    Online Artículo Texto
    Isocitrate dehydrogenase mutation is associated with tumor location and magnetic resonance imaging characteristics in astrocytic neoplasms
  16. 1156
    “…The presence of an isocitrate dehydrogenase (IDH1/2) mutation in gliomas is associated with favorable outcomes compared to gliomas without the mutation (IDH1/2 wild-type, WT). …”
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    Online Artículo Texto
    Oncogenic transgelin-2 is differentially regulated in isocitrate dehydrogenase wild-type vs. mutant gliomas
  17. 1157
    “…Subgroup analysis revealed that the 1-year PFS of IDH-mut/1p/19q codeletion group and IDH-mut/1p/19q noncodeletion group was significantly higher than in IDH-wild type patients. …”
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    The prognosis of gliomas with different molecular subtypes in the era of intensity-modulated radiation therapy (IMRT)
  18. 1158
    “…IDH1/2 mutations are heterozygous, and affect a single arginine residue. …”
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    Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
  19. 1159
    “…A meta-analysis of these studies included 111 MDS patients IDH mutations and 1671 MDS patients with wild-type IDH1/2. …”
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    Prognostic Value of Isocitrate Dehydrogenase Mutations in Myelodysplastic Syndromes: A Retrospective Cohort Study and Meta-Analysis
  20. 1160
    “…Cancer linked isocitrate dehydrogenase (IDH) 1 variants, notably R132H IDH1, manifest a ‘gain-of-function’ to reduce 2-oxoglutarate to 2-hydroxyglutarate. …”
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    Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1
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