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101por Chaturvedi, A, Herbst, L, Pusch, S, Klett, L, Goparaju, R, Stichel, D, Kaulfuss, S, Panknin, O, Zimmermann, K, Toschi, L, Neuhaus, R, Haegebarth, A, Rehwinkel, H, Hess-Stumpp, H, Bauser, M, Bochtler, T, Struys, E A, Sharma, A, Bakkali, A, Geffers, R, Araujo-Cruz, M M, Thol, F, Gabdoulline, R, Ganser, A, Ho, A D, von Deimling, A, Rippe, K, Heuser, M, Krämer, A“…Here we report the characterization of BAY1436032, a novel pan-mutant IDH1 inhibitor, both in vitro and in vivo. BAY1436032 specifically inhibits R-2HG production and colony growth, and induces myeloid differentiation of AML cells carrying IDH1R132H, IDH1R132C, IDH1R132G, IDH1R132L and IDH1R132S mutations. …”
Publicado 2017
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102“…Here we demonstrate that regulation of a long noncoding RNA (lncRNA), named IDH1-AS1, enables c-Myc to collaborate with HIF1α in activating the Warburg effect under normoxia. c-Myc transcriptionally repressed IDH1-AS1, which, upon expression, promoted homodimerization of IDH1 and thus enhanced its enzymatic activity. …”
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103por Hosseini, Seyyed Ali, Hosseini, Elahe, Hajianfar, Ghasem, Shiri, Isaac, Servaes, Stijn, Rosa-Neto, Pedro, Godoy, Laiz, Nasrallah, MacLean P., O’Rourke, Donald M., Mohan, Suyash, Chawla, Sanjeev“…SIMPLE SUMMARY: To differentiate IDH-mutant grade 4 astrocytomas from IDH-wild-type glioblastomas, two MRI sequences (post-contrast T1 and T2-FLAIR) were acquired from 57 patients. …”
Publicado 2023
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104por Wang, Dandan, Zheng, Lichuan, Cheng, Bowie Yik Ling, Sin, Chun-Fung, Li, Runsheng, Tsui, Sze Pui, Yi, Xinyu, Ma, Alvin Chun Hang, He, Bai Liang, Leung, Anskar Yu Hung, Sun, Xuan“…We generated zebrafish models of IDH2(R172K) and IDH2(R140Q) AML and reported their pathologic, functional and transcriptomic features and therapeutic responses to target therapies. …”
Publicado 2023
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105por Wang, Zheng, Bao, Zhaoshi, Yan, Wei, You, Gan, Wang, Yinyan, Li, Xuejun, Zhang, Wei“…BACKGROUND: To date, no prognostic microRNAs (miRNAs) for isocitrate dehydrogenase 1 (IDH1) wild-type glioblastoma multiformes (GBM) have been reported. …”
Publicado 2013
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106por Molenaar, Remco J, Coelen, Robert JS, Khurshed, Mohammed, Roos, Eva, Caan, Matthan WA, van Linde, Myra E, Kouwenhoven, Mathilde, Bramer, Jos AM, Bovée, Judith VMG, Mathôt, Ron A, Klümpen, Heinz-Josef, van Laarhoven, Hanneke WM, van Noorden, Cornelis JF, Vandertop, W Peter, Gelderblom, Hans, van Gulik, Thomas M, Wilmink, Johanna W“…Mutations in the genes IDH1 and IDH2 (isocitrate dehydrogenase 1 and 2) occur in 60% of chondrosarcoma, 80% of WHO grade II–IV glioma and 20% of intrahepatic cholangiocarcinoma. …”
Publicado 2017
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107por Olarte, Irma, García, Anel, Ramos, Christian, Arratia, Brenda, Centeno, Federico, Paredes, Johanna, Rozen, Etta, Kassack, Juan, Collazo, Juan, Martínez, Adolfo“…CONCLUSION: The frequency of IDH1 and IDH2 gene mutations in the sample was similar to that reported in other studies. …”
Publicado 2019
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108por Tejera, Dalissa, Kushnirsky, Marina, Gultekin, Sakir H, Lu, Min, Steelman, Lori, de la Fuente, Macarena I“…Strong interest in targeting IDH mutations has led to a variety of studies in both hematologic malignancies and solid tumors and to the approval of IDH inhibitors such as ivosidenib, an IDH1 inhibitor, in hematologic malignancies. …”
Publicado 2020
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109por Chang, Yu-Zhou, Li, Guan-Zhang, Pang, Bo, Zhang, Ke-Nan, Zhang, Xiao-Hui, Wang, Yong-Zhi, Jiang, Zhong-li, Chai, Rui-Chao“…Isocitric dehydrogenase (IDH)-wild type diffuse gliomas, which have a poorer prognosis than their IDH-mutant counterparts, are also accompanied with high heterogeneity. …”
Publicado 2020
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110por Gbyli, Rana, Song, Yuanbin, Liu, Wei, Gao, Yimeng, Biancon, Giulia, Chandhok, Namrata S, Wang, Xiaman, Fu, Xiaoying, Patel, Amisha, Sundaram, Ranjini, Tebaldi, Toma, Mamillapalli, Padmavathi, Zeidan, Amer M, Flavell, Richard A., Prebet, Thomas, Bindra, Ranjit S., Halene, Stephanie“…Recurring mutations, such as mutations in isocitrate dehydrogenase-1 and −2 (IDH1/2) are found in subsets of AML and MDS, are therapeutically targeted by mutant enzyme-specific small molecule inhibitors (IDH(m)i). …”
Publicado 2022
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111por Ajisebutu, Andrew, Nassiri, Farshad, Wang, Justin Z, Mamatjan, Yasin, Nejad, Romina, Patil, Vikas, Liu, Jeff, Voisin, Mathew R, Mansouri, Sheila, Karimi, Shirin, Chakravarthy, Ankur, Chen, Eric, De Carvalho, Daniel D, Aldape, Kenneth, Zadeh, Gelareh“…Mutations in isocitrate dehydrogenase (IDH) enzymes are recognised to drive the molecular footprint of diffuse gliomas, and patients with IDH-mutant gliomas have overall favorable outcomes compared to patients with IDH wildtype tumors. …”
Publicado 2023
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112por Nguyen, Thanh Binh“…PURPOSE: To evaluate the diagnostic accuracy of preoperative MRS in the determination of the IDH status and grade in patients with newly diagnosed gliomas. …”
Publicado 2023
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113por RIBEIRO, MARCELO BARBOSA, IBIAPINA, JERÚSIA OLIVEIRA, BAPTISTA, ANDRÉ MATHIAS, CAMARGO, OLAVO PIRES DE“…OBJECTIVE: To perform an immunohistochemical evaluation using the IDH1 and Ki67 markers in patients who underwent treatment for chondrosarcoma in a reference service center in Brazil. …”
Publicado 2023
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114por Lewandowska, Marzena, Szylberg, T, Roszkowski, K, Furtak, J, Windorbska, W, Rytlewska, J, Jóźwicki, WEnlace del recurso
Publicado 2012
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115por Reitman, Zachary J., Choi, Bryan D., Spasojevic, Ivan, Bigner, Darell D., Sampson, John H., Yan, Hai“…We applied cancer-associated mutations from isocitrate dehydrogenases (IDHs) to homologous residues in the active sites of homoisocitrate dehydrogenases (HIDHs) to derive enzymes that catalyze the conversion of 2-oxoadipate to (R)-2-hydroxyadipate, a critical step for adipic acid production. …”
Publicado 2012
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116por Yonal-Hindilerden, Ipek, Daglar-Aday, Aynur, Hindilerden, Fehmi, Akadam-Teker, Basak, Yilmaz, Ceylan, Nalcaci, Meliha, Yavuz, Akif Selim, Sargin, Deniz“…IDH mutations in ET patients included one IDH1 R132C and one IDH2 R140Q. …”
Publicado 2016
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117por Wang, Jing, Zhao, Yi-ying, Li, Jian-feng, Guo, Cheng-cheng, Chen, Fu-rong, Su, Hong-kai, Zhao, Hua-fu, Long, Ya-kang, Shao, Jian-yong, Tony To, Shing-shun, Chen, Zhong-ping“…Mutations in IDH genes are observed in over 70% of low-grade gliomas and some cases of glioblastoma. …”
Publicado 2015
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118por May, Anthony C., Ehrlich, Rachel L., Balashov, Sergey, Ehrlich, Garth D., Shanmugam, Mayilvahanan, Fine, Daniel H., Ramasubbu, Narayanan, Mell, Joshua Chang, Cugini, Carla“…We report here the complete genomic sequence and methylome of Aggregatibacter actinomycetemcomitans strain IDH781. This rough strain is used extensively as a model organism to characterize localized aggressive periodontitis pathogenesis, the basic biology and oral cavity colonization of A. actinomycetemcomitans, and its interactions with other members of the oral microbiome.…”
Publicado 2016
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119por Jalbert, Llewellyn E., Elkhaled, Adam, Phillips, Joanna J., Neill, Evan, Williams, Aurelia, Crane, Jason C., Olson, Marram P., Molinaro, Annette M., Berger, Mitchel S., Kurhanewicz, John, Ronen, Sabrina M., Chang, Susan M., Nelson, Sarah J.“…A key factor in clinical decision-making is that patients with mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) oncogenes are more likely to have a favorable outcome and be sensitive to treatment. …”
Publicado 2017
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120por Senhaji, Nadia, Louati, Sara, Chbani, Laila, El Fatemi, Hind, Hammas, Nawal, Mikou, Karima, Maaroufi, Mustapha, Benzagmout, Mohammed, Boujraf, Said, El Bardai, Sanae, Giry, Marine, Marie, Yannick, Chaoui El Faiz, Mohammed, Mokhtari, Karima, Idbaih, Ahmed, Amarti, Afaf, Bennis, Sanae“…Results. The R132H IDH1 mutation was observed in 8 of 65 tumor samples (12.31%). …”
Publicado 2017
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