Mostrando 101 - 120 Resultados de 4,168 Para Buscar '"IDH"', tiempo de consulta: 0.10s Limitar resultados
  1. 101
    “…Here we report the characterization of BAY1436032, a novel pan-mutant IDH1 inhibitor, both in vitro and in vivo. BAY1436032 specifically inhibits R-2HG production and colony growth, and induces myeloid differentiation of AML cells carrying IDH1R132H, IDH1R132C, IDH1R132G, IDH1R132L and IDH1R132S mutations. …”
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  2. 102
    “…Here we demonstrate that regulation of a long noncoding RNA (lncRNA), named IDH1-AS1, enables c-Myc to collaborate with HIF1α in activating the Warburg effect under normoxia. c-Myc transcriptionally repressed IDH1-AS1, which, upon expression, promoted homodimerization of IDH1 and thus enhanced its enzymatic activity. …”
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  3. 103
    “…SIMPLE SUMMARY: To differentiate IDH-mutant grade 4 astrocytomas from IDH-wild-type glioblastomas, two MRI sequences (post-contrast T1 and T2-FLAIR) were acquired from 57 patients. …”
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  4. 104
    “…We generated zebrafish models of IDH2(R172K) and IDH2(R140Q) AML and reported their pathologic, functional and transcriptomic features and therapeutic responses to target therapies. …”
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  5. 105
    “…BACKGROUND: To date, no prognostic microRNAs (miRNAs) for isocitrate dehydrogenase 1 (IDH1) wild-type glioblastoma multiformes (GBM) have been reported. …”
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  6. 106
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  8. 108
    “…Strong interest in targeting IDH mutations has led to a variety of studies in both hematologic malignancies and solid tumors and to the approval of IDH inhibitors such as ivosidenib, an IDH1 inhibitor, in hematologic malignancies. …”
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  9. 109
    “…Isocitric dehydrogenase (IDH)-wild type diffuse gliomas, which have a poorer prognosis than their IDH-mutant counterparts, are also accompanied with high heterogeneity. …”
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  10. 110
    “…Recurring mutations, such as mutations in isocitrate dehydrogenase-1 and −2 (IDH1/2) are found in subsets of AML and MDS, are therapeutically targeted by mutant enzyme-specific small molecule inhibitors (IDH(m)i). …”
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  11. 111
    “…Mutations in isocitrate dehydrogenase (IDH) enzymes are recognised to drive the molecular footprint of diffuse gliomas, and patients with IDH-mutant gliomas have overall favorable outcomes compared to patients with IDH wildtype tumors. …”
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  12. 112
    por Nguyen, Thanh Binh
    Publicado 2023
    “…PURPOSE: To evaluate the diagnostic accuracy of preoperative MRS in the determination of the IDH status and grade in patients with newly diagnosed gliomas. …”
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  13. 113
    “…OBJECTIVE: To perform an immunohistochemical evaluation using the IDH1 and Ki67 markers in patients who underwent treatment for chondrosarcoma in a reference service center in Brazil. …”
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  14. 114
  15. 115
    “…We applied cancer-associated mutations from isocitrate dehydrogenases (IDHs) to homologous residues in the active sites of homoisocitrate dehydrogenases (HIDHs) to derive enzymes that catalyze the conversion of 2-oxoadipate to (R)-2-hydroxyadipate, a critical step for adipic acid production. …”
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  16. 116
  17. 117
    “…Mutations in IDH genes are observed in over 70% of low-grade gliomas and some cases of glioblastoma. …”
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  18. 118
    “…We report here the complete genomic sequence and methylome of Aggregatibacter actinomycetemcomitans strain IDH781. This rough strain is used extensively as a model organism to characterize localized aggressive periodontitis pathogenesis, the basic biology and oral cavity colonization of A. actinomycetemcomitans, and its interactions with other members of the oral microbiome.…”
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  19. 119
    “…A key factor in clinical decision-making is that patients with mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) oncogenes are more likely to have a favorable outcome and be sensitive to treatment. …”
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  20. 120
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