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  1. 1181
    “…Isocitrate dehydrogenase 1 (IDH1) is the most frequently mutated metabolic gene in cancer. …”
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    Isocitrate dehydrogenase variants in cancer — Cellular consequences and therapeutic opportunities
  2. 1182
    “…This hypothesis was tested by expressing mutant IDH1 with a point alteration—converting arginine 132 to histidine—within glioma cell lines that contain wild-type IDH1. …”
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    Mutant Isocitrate Dehydrogenase 1 Expression Enhances Response of Gliomas to the Histone Deacetylase Inhibitor Belinostat
  3. 1183
    “…A recent research of cancer has indicated that the mutant of isocitrate dehydrogenase 1 and 2 (IDH1 and 2) genes will induce various cancers, including chondrosarcoma, cholangiocarcinomas, and acute myelogenous leukemia due to the effect of point mutations in the active-site arginine residues of isocitrate dehydrogenase (IDH), such as IDH1/R132, IDH2/R140, and IDH2/R172. …”
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    Potential Mitochondrial Isocitrate Dehydrogenase R140Q Mutant Inhibitor from Traditional Chinese Medicine against Cancers
  4. 1184
    “…Despite studies reporting potential interlinks between IDH2 and various diseases, there is lack of effort to comprehensively characterize signature(s) of IDH2 knockout (IDH2 KO) mice. …”
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    Hepatic Transcriptomics Reveals that Lipogenesis Is a Key Signaling Pathway in Isocitrate Dehydrogenase 2 Deficient Mice
  5. 1185
    “…BACKGROUND: Isolated diastolic hypertension (IDH) has been actively discussed for the last two decades because of its prevalence in a younger population and its association with cardiovascular disease. …”
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    Isolated diastolic hypertension and its risk factors in semi-rural population of South India
  6. 1186
    “…Our study attempted to identify hub genes related to isocitrate dehydrogenase (IDH) mutation in glioma and develop a prognostic model for IDH-mutant glioma patients. …”
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    Hub gene identification and prognostic model construction for isocitrate dehydrogenase mutation in glioma
  7. 1187
    “…The alteration hotspots in codons IDH1 (R132) and IDH2 (R172 and R140) were examined via direct sequencing. …”
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    Investigation of Isocitrate Dehydrogenase 1 and 2 Mutations in Acute Leukemia Patients in Saudi Arabia
  8. 1188
    “…However, current targeted inhibitors of IDH1 mutation (AG120 and IDH305) reversed these effects caused by IDH1 mutation. …”
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    Isocitrate dehydrogenase 1 mutation in cholangiocarcinoma impairs tumor progression by sensitizing cells to ferroptosis
  9. 1189
    “…To overcome metabolic stress induced by these alterations, IDH-mutated (IDH(mut)) cancers utilize rescue mechanisms comprising pathways in which glutaminase and glutamate dehydrogenase (GLUD) are involved. …”
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    Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate
  10. 1190
    “…We studied 168 patients separated into five groups: Group 1: 65 patients with ODG carrying an IDH1 or IDH2 mutation (IDH-mutant) and 1p/19q–codeletion, Group 2: 23 patients with anaplastic astrocytoma (AA), IDH-mutant, Group 3: 13 patients with GBM, IDH-mutant, Group 4: 15 patients with AA, IDH-wildtype (WT), and Group 5: 52 patients with GBM, IDH-WT. …”
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    The frequency and prognostic effect of TERT promoter mutation in diffuse gliomas
  11. 1191
    “…The 18-month survival rate for the IDH-mutant was 75% compared to 48% for their IDH-wildtype counterparts. …”
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    O(6)-methylguanine-DNA methyltransferase promoter methylation and isocitrate dehydrogenase mutation as prognostic factors in a cohort of Saudi patients with glioblastoma
  12. 1192
    “…Prediction of IDH may facilitate timely interventions and eventually reduce IDH rates. …”
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    Real-time prediction of intradialytic hypotension using machine learning and cloud computing infrastructure
  13. 1193
    “…A combined analysis of expression of IDH1 and ATRX versus IDH1, ATRX, and p53 with WHO grade showed a statistically significant association. …”
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    Gliomas - An experience based on molecular markers
  14. 1194
    “…Gemistocytic differentiation is a rare histological feature seen in IDH mutant Astrocytomas. The 2021 World Health Organization (WHO) retains the diagnosis of IDH mutant Astrocytoma with its classical histology and tumors with the rare histological pattern of gemistocytic differentiation. …”
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    Gemistocytic Differentiation in Isocitrate Dehydrogenase Mutant Astrocytomas: A Histopathological and Survival Analysis
  15. 1195
    “…Pseudomonas aeruginosa PAO1, as an experimental model for Gram-negative bacteria, harbors two NADP(+)-dependent isocitrate dehydrogenases (NADP-IDHs) that were evolved from its ancient counterpart NAD-IDHs. …”
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    Two Different Isocitrate Dehydrogenases from Pseudomonas aeruginosa: Enzymology and Coenzyme-Evolutionary Implications
  16. 1196
    “…Intradialytic hypotension (IDH) may lead to a poor life quality and was associated with cardiovascular mortality in patients under hemodialysis. …”
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    Low central blood pressure and sympathetic activity predispose for the development of intradialytic hypotension
  17. 1197
    “…SIMPLE SUMMARY: IDH mutation is one of the most important prognostic biomarkers in glioma management. …”
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    Non-Invasive Assessment of Isocitrate Dehydrogenase-Mutant Gliomas Using Optimized Proton Magnetic Resonance Spectroscopy on a Routine Clinical 3-Tesla MRI
  18. 1198
    “…We identified 11 maize IDH genes (ZmIDH) and classified these genes into ZmNAD-IDH and ZmNADP-IDH groups based on their different coenzymes (NAD(+) or NADP(+)). …”
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    Characterization of the Isocitrate Dehydrogenase Gene Family and Their Response to Drought Stress in Maize
  19. 1199
    “…MRI features were correlated with genotype, classified as IDH-mutant and 1p/19q-codeleted (IDH(mut)/1p19q(codel)), IDH-mutant and 1p/19q-intact (IDH(mut)/1p19q(int)), or IDH-wildtype (IDH(wt)). …”
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    Conventional MRI features can predict the molecular subtype of adult grade 2–3 intracranial diffuse gliomas
  20. 1200
    por Venugopal, Sangeetha, Watts, Justin
    Publicado 2023
    “…The discovery of isocitrate dehydrogenase 1 (IDH1) mutations in acute myeloid leukemia (AML) and the resounding success of molecularly targeted therapies in related myeloid malignancies swiftly prompted the development of IDH1(mut) inhibitors. …”
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    Olutasidenib: from bench to bedside
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