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  1. 1221
    “…In the past 2 years, two mutant IDH (mutIDH) inhibitors, Enasidenib (AG-221), and Ivosidenib (AG-120), have been FDA-approved for IDH-mutant relapsed or refractory acute myeloid leukemia (AML) based on phase 1 safety and efficacy data and continue to be studied in trials in hematologic malignancies, as well as in glioma, cholangiocarcinoma, and chondrosarcoma. …”
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    Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics
  2. 1222
    “…Histological tumour grade depends on age at diagnosis in patients with IDH1, TP53, ATRX, and EGFR mutations. Age of patients with wild-type IDH1 and EGFR increased with increase in tumour grade, while the age of patients with IDH1 or EGFR mutation remained constant. …”
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    Transcriptomic Landscape of Lower Grade Glioma Based on Age-Related Non-Silent Somatic Mutations
  3. 1223
    “…AGI was compared between different tumor types (N = 51, 30 IDH mutant and 21 IDH wild type). Metabolic MR parameters were correlated with (18)F-FDG uptake (N = 8, IDH wild-type glioblastoma), expression of key glycolytic proteins using immunohistochemistry (N = 38 samples, 21 from IDH mutant and 17 from IDH wild type), and bioenergetics analysis on purified tumor cells (N = 7, IDH wild-type high grade). …”
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    “Aerobic glycolytic imaging” of human gliomas using combined pH-, oxygen-, and perfusion-weighted magnetic resonance imaging
  4. 1224
    “…Elderly patients show increased frequencies of IDH mutations with high chemoresistance and relapse rates despite recent therapeutic advances. …”
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    Isocitrate dehydrogenase 1 mutation drives leukemogenesis by PDGFRA activation due to insulator disruption in acute myeloid leukemia (AML)
  5. 1225
    “…AIMS: Somatic mutations in IDH1 and IDH2 are described in glioblastomas (GBMs). …”
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    HOT mutation screening in human glioblastomas
  6. 1226
    “…Genetically predicted increase in the platelet to lymphocyte ratio (PLR) was associated with an increased risk of glioma (odds ratio (OR)=1.25, p=0.005), especially in IDH-mutant (IDH(mut) OR=1.38, p=0.007) and IDH(mut) 1p/19q non-codeleted (IDH(mut-noncodel) OR=1.53, p=0.004) tumors. …”
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    Genetic predisposition to altered blood cell homeostasis is associated with glioma risk and survival
  7. 1227
    “…OBJECTIVES: Little is known about isolated diastolic hypertension (IDH) among different ethnicity groups. We aimed to investigate the prevalence and risk factors for IDH among the major ethnicity population i.e. …”
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    Prevalence of Isolated Diastolic Hypertension and Associated Risk Factors among Different Ethnicity Groups in Xinjiang, China
  8. 1228
    “…Recently our group conducted a series of experimental studies, which showed that muIDH1 gliomas have a significant global reduction of immune cells and suggested that the longer survival time of mice with CIMP gliomas may be due to the IDH mutation and its effect on reducing of the tumor-infiltrated immune cells. …”
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    Mathematical modeling of PDGF-driven glioma reveals the dynamics of immune cells infiltrating into tumors
  9. 1229
    “…RESULTS: A loss of p16 expression predicted a significantly worse outcome in all glioma patients (n = 326, p < .001), in the IDH-mutant glioma patients (n = 103, p = .010), and in the IDH-mutant astrocytoma patients (n = 73, p = .032). …”
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    The prognostic significance of p16 expression pattern in diffuse gliomas
  10. 1230
    “…They split into astrocytoma- (IDH-A) and oligodendroglioma-like (IDH-O) tumors both carrying mutations(s) at the isocitrate dehydrogenase (IDH) gene and into IDH wild type (IDH-wt) gliomas of glioblastoma resemblance. …”
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    High-Resolution Cartography of the Transcriptome and Methylome Landscapes of Diffuse Gliomas
  11. 1231
    “…Inhibitors of mutant IDH enzymes and their 2-HG production have been approved by the FDA to be used in patients. …”
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    Activation of Vitamin D Receptor Pathway Enhances Differentiating Capacity in Acute Myeloid Leukemia with Isocitrate Dehydrogenase Mutations
  12. 1232
    “…OBJECTIVES: Haemoglobin concentration is a potentially modifiable factor that may help lower the risk of intradialytic hypotension (IDH), but its association with IDH is not well understood. …”
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    Association between haemoglobin concentration and intradialytic hypotension in patients undergoing maintenance haemodialysis: a retrospective cohort study
  13. 1233
    “…The biological functions of IDH1 were examined in breast cancer cells with IDH1 knockdown, including proliferation, migration and invasion. …”
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    Isocitrate dehydrogenase 1–snail axis dysfunction significantly correlates with breast cancer prognosis and regulates cell invasion ability
  14. 1234
    “…In previous studies, it has shown excellent specificity but limited sensitivity for IDH-mut astrocytomas. Whether the mismatch sign is a marker of a clinically relevant subtype of IDH-mut astrocytomas is unknown. …”
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    The clinical significance of the T2-FLAIR mismatch sign in grade II and III gliomas: a population-based study
  15. 1235
    “…All hemodynamic parameters, apart from rising time, demonstrated significant differences between IDH-mutant and IDH-wildtype adult-type diffuse gliomas. …”
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    Quantitative analysis using intraoperative contrast-enhanced ultrasound in adult-type diffuse gliomas with isocitrate dehydrogenase mutations: association between hemodynamics and molecular features
  16. 1236
    “…BACKGROUND: Intradialytic hypertension (IDH) increases morbidity and mortality. The prevalence in South Africa is unknown. …”
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    Intradialytic hypertension during chronic haemodialysis and subclinical fluid overload assessed by bioimpedance spectroscopy
  17. 1237
    “…The results revealed that glioblastomas were IDH-wildtype (IDH(WT); n = 38) and IDH-mutant (IDH(MUT); n = 3). …”
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    Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches
  18. 1238
    “…Isocitrate dehydrogenase 1 (IDH1) mutations are common in gliomas, acute myeloid leukemia, and chondrosarcoma. …”
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    Novel canine isocitrate dehydrogenase 1 mutation Y208C attenuates dimerization ability
  19. 1239
    “…INTRODUCTION: Approximately 15 to 33% of all dialysis treatments are complicated by intradialytic hypotension (IDH). In this study, we tested the hypothesis that the intravenous administration of hydrocortisone prior to HD treatment could prevent IDH or at least decrease the drop in the blood pressure resulting from IDH. …”
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    Effect of Hydrocortisone on Intradialytic Hypotension: A Preliminary Investigational Study
  20. 1240
    “…The most frequently mutated metabolic genes in human cancer are those encoding the enzymes isocitrate dehydrogenase 1 (IDH1) and IDH2; these mutations have so far been identified in more than 20 tumor types. …”
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    Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations
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