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1241“…The unique immune microenvironment plays a crucial role in the malignant progression of isocitrate dehydrogenase (IDH) mutant gliomas. IDH mutations in glioma can inhibit tumor-associated immune system evasion of NK cell immune surveillance. …”
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1242“…MATERIALS AND METHODS: We retrospectively evaluated 56 lower-grade diffuse gliomas and divided them into three categories: IDH-wild group (IDH(wt), 16cases); IDH mutant with the intact 1p or 19q group (IDH(mut)/1p19q(+), 18cases); and IDH mutant with the 1p/19q codeleted group (IDH(mut)/1p19q(−), 22cases). …”
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1243“…Isolated diastolic hypertension (IDH), however, tends to be ignored due to insufficient recognition. …”
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1244por Tateiwa, Daisuke, Yamasaki, Ryoji, Tei, Rinsei, Shin, Yasushi, Ariga, Kenta, Hayashida, Kenji, Wada, Eiji“…Intradural disk herniation (IDH) is a rare condition, occurring more often at the L4-5 level. …”
Publicado 2018
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1245“…Intradialytic hypotension (IDH) is a common complication in hemodialysis. IDH can induce vomiting, chest tightness and syncope, and hemodialysis shall be discontinued in patients with severe IDH. …”
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1246por Mora-Bravo, Franklin G, De-La-Cruz, Guadalupe, Rivera, Sonia, Ramírez, Alfonso Mariscal, Raimann, Jochen G, Pérez-Grovas, Héctor“…Group 1 showed 31 treatments (8.2%) with IDH whereas group 6 showed IDH in only 15 sessions (4% of all treatments). …”
Publicado 2012
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1247por Lee, Kyu Sang, Choe, Gheeyoung, Nam, Kyung Han, Seo, An Na, Yun, Sumi, Kim, Kyung Ju, Cho, Hwa Jin, Park, Sung Hye“…Expression of IDH-1 and EGFR(-)/p53(+) was positively correlated with young age. …”
Publicado 2013
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1248por Whitehall, VLJ, Dumenil, TD, McKeone, DM, Bond, CE, Bettington, ML, Buttenshaw, RL, Bowdler, L, Montgomery, GW, Wockner, LF, Leggett, BA“…The R132C IDH1 mutation was detected in 4/166 cancers. All IDH1 mutations were in CIMP cancers that were BRAF mutant and microsatellite stable (4/45, 8.9%). …”
Publicado 2014
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1249por Chan, Aden Ka-Yin, Yao, Yu, Zhang, Zhenyu, Shi, Zhifeng, Chen, Liang, Chung, Nellie Yuk-Fei, Liu, Joseph Shu-Ming, Li, Kay Ka-Wai, Chan, Danny Tat-Ming, Poon, Wai Sang, Wang, Ying, Zhou, Liangfu, Ng, Ho-Keung“…Prognostic association of grading was independent of other prognostic variables including age, histological type, IDH1/2, 1p/19q and TERTp status. No single marker, including IDH1/2, superseded grading in prognostication, indicating grading was still a very important tool. …”
Publicado 2015
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1250por Prokopchuk, Olga, Andres, Stephanie, Becker, Karen, Holzapfel, Konstantin, Hartmann, Daniel, Friess, Helmut“…For IHCC, mutations in IDH1/IDH2 are associated with higher survival rates. …”
Publicado 2016
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1251por Chen, Xuan, Li, Qingbao, Wang, Cong, Xu, Wenzhe, Han, Lihui, Liu, Yuan, Liu, Bowen, Guan, Shanghui, Tan, Bingxu, Wang, Jianbo, Wang, Nana, Song, Qingxu, Jia, Yibin, Wang, Jianzhen, Zhao, Linli, Cheng, Yufeng“…We aimed to investigate the pattern of expression and clinical significance of isocitrate dehydrogenase 1(IDH1) in esophageal squamous cell carcinoma (ESCC). …”
Publicado 2016
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1252por Hu, Wan-Ming, Wang, Fang, Xi, Shao-Yan, Zhang, Xiao, Lai, Jun-Peng, Wu, Hui-Yu, Liu, Li-Ling, Sai, Ke, Zeng, Jing“…Methods: The expression of IDH1, ATRX, PHH3, P53 and Ki67 was detected by IHC. …”
Publicado 2020
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1253por Bezerra, Matheus F., Larrazábal, Bruna R., Lima, Aleide S., Mello, Mariana R., Pimentel, Raphael F., Weinhäuser, Isabel, Costa, Fernando F., Fertrin, Kleber Y., Araújo, Aderson S., Machado, Cíntia G., Bezerra, Marcos A., Lucena-Araujo, Antonio R.“…While the JAK2 V617F mutation was the most frequent in the MDS patients, the FLT3, NPM1, IDH1 and IDH2 mutations were more frequently found in the secondary AML group. …”
Publicado 2022
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1254por Liu, Han-Qing, Li, Wei-Xin, An, Ya-Wen, Wu, Tao, Jiang, Guang-Yu, Dong, Yu, Chen, Wei-Xin, Wang, Jian-Chun, Wang, Cheng, Song, Shuo“…However, the underlying mechanisms on both mutations of glioma patients in IDH1 and TP53 are still unclear. Aim: To find the potential target markers in GBM and LGG patients with IDH1 and TP53 mutation.Method: A total of 1122 glioma patients from The Cancer Genome Atlas were enrolled and divided as wild-type (without IDH1 and TP53 mutations) or both mutant (both IDH1 and TP53 mutations). …”
Publicado 2022
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1255por Allinovi, Marco, Palazzini, Giulia, Lugli, Gianmarco, Gianassi, Iacopo, Dallari, Lorenzo, Laudicina, Selene, Gregori, Marco, Rossi, Francesco, Giannerini, Daniele, Cutruzzulà, Roberta, Dervishi, Egrina, Biagini, Maria, Cirami, Calogero Lino“…Intradialytic hypotension (IDH) is a frequent and well-known complication of hemodialysis, occurring in about one third of patients. …”
Publicado 2022
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1256“…Mutations in isocitrate dehydrogenase (IDH) are commonly observed in lower-grade glioma and secondary glioblastomas. …”
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1257por Ahn, Jae-Sook, Kim, Hyeoung-Joon, Kim, Yeo-Kyeoung, Lee, Seung-Shin, Ahn, Seo-Yeon, Jung, Sung-Hoon, Yang, Deok-Hwan, Lee, Je-Jung, Park, Hee Jeong, Choi, Seung Hyun, Jung, Chul Won, Jang, Jun-Ho, Kim, Hee Je, Moon, Joon Ho, Sohn, Sang Kyun, Won, Jong-Ho, Kim, Sung-Hyun, Michael, Szardenings, Minden, Mark D., Hwan, Dennis Dong Kim“…Mutation rates were 13.1% for TET2(mut), 6.7% for IDH1(mut), and 13.9% for IDH2(mut). The prevalence of TET2 and/or IDH1/2 was 33.1% (124/375). …”
Publicado 2016
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1258por Wang, Pan, Dong, Ying, Zuo, Kun, Han, Chunming, Jiao, Jie, Yang, Xinchun, Li, Jing“…In order to identify whether the composition of bacterial taxa and functional modules shift in ISH and IDH, we performed a metagenomic sequencing analysis of fecal samples from 15 controls, 14 ISH, and 11 IDH. …”
Publicado 2021
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1259por Beaubien-Souligny, William, Yang, Yifan, Burns, Karen E. A., Friedrich, Jan O., Meraz-Muñoz, Alejandro, Clark, Edward G., Adhikari, Neill K., Bagshaw, Sean M., Wald, Ron“…BACKGROUND: Transition from continuous renal replacement therapy (CRRT) to intermittent renal replacement therapy (IRRT) can be associated with intra-dialytic hypotension (IDH) although data to inform the definition of IDH, its incidence and clinical implications, are lacking. …”
Publicado 2021
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1260por Tamura, Kaoru, Inaji, Motoki, Kobayashi, Daisuke, Hara, Shoko, Karakama, Jun, Sugawara, Takashi, Tanaka, Yoji, Nariai, Tadashi, Ishii, Kenji, Maehara, Taketoshi“…By molecular diagnosis, 11 diffuse astrocytomas and 17 anaplastic astrocytomas were diagnosed as “IDH-mutant”, while 14 diffuse astrocytomas and 29 anaplastic astrocytomas were diagnosed as “IDH-wild”. 5 out of 77 grade IV tumors had IDH mutation. 4 tumors were diagnosed as “Diffuse midline glioma, H3 K27M-mutant”. …”
Publicado 2021
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