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  1. 1261
    “…INTRODUCTION: Glioblastoma (GBM), isocitrate dehydrogenase (IDH) wild-type (IDH(wt)), and grade 4 astrocytomas, IDH mutant (IDH(mut)), are the most common and aggressive primary malignant brain tumors in adults. …”
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    Cancer immune profiling unveils biomarkers, immunological pathways, and cell type score associated with glioblastoma patients’ survival
  2. 1262
    “…INTRODUCTION: Intramural duodenal hematoma (IDH) is a rare pathological entity that occurs as a complication of trauma, pancreatitis, peptic ulcer disease or endoscopic biopsy procedures. …”
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    Surgical management of complicated intra-mural duodenal hematoma: A case-report and review of literature
  3. 1263
    “…Isocitrate dehydrogenase (IDH) is a key rate-limiting enzyme in the Krebs cycle that plays an important role in energy metabolism. …”
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    Isocitrate Dehydrogenase Mutations in Glioma: From Basic Discovery to Therapeutics Development
  4. 1264
    “…Among these alterations, an important role is played by two mutant enzymes of the citric acid cycle, isocitrate dehydrogenase (IDH), IDH1 and IDH2, occurring in about 20% of AMLs, which leads to the production of an oncogenic metabolite R-2-hydroxy-glutarate (R-2-HG); this causes a DNA hypermethylation and an inhibition of hematopoietic stem cell differentiation. …”
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    Isocitrate Dehydrogenase Mutations in Myelodysplastic Syndromes and in Acute Myeloid Leukemias
  5. 1265
    por Smolková, Katarína, Ježek, Petr
    Publicado 2012
    “…Isocitrate dehydrogenase 2 (IDH2) is located in the mitochondrial matrix. IDH2 acts in the forward Krebs cycle as an NADP(+)-consuming enzyme, providing NADPH for maintenance of the reduced glutathione and peroxiredoxin systems and for self-maintenance by reactivation of cystine-inactivated IDH2 by glutaredoxin 2. …”
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    The Role of Mitochondrial NADPH-Dependent Isocitrate Dehydrogenase in Cancer Cells
  6. 1266
    “…Proneural was most dominant in IDH-mut tumors (78.5%), mesenchymal more common among IDH-wt tumors (63.6%). …”
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    The clinical value of proneural, classical and mesenchymal protein signatures in WHO 2021 adult-type diffuse lower-grade gliomas
  7. 1267
    “…The aim of the present study was to determine the prevalence of isocitrate dehydrogenase (IDH1 and IDH2) mutations and epidermal growth factor receptor variant (EGFRv)III transcript expression in Saudi Arabian patients with glioma. …”
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    EGFRvIII expression and isocitrate dehydrogenase mutations in patients with glioma
  8. 1268
    “…Compared with individuals with normal diastolic BP, individuals with stage 1 and stage 2 IDH were older and more likely to be men. Prevalence of classic risk factors was higher in patients with IDH. …”
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    Association of Isolated Diastolic Hypertension Based on the Cutoff Value in the 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines With Subsequent Cardiovascular Events in the General Population
  9. 1269
    “…In this study, the immunohistochemistry-staining of mutant IDH1 R132H, Ki-67, and PD-L1 were carried out to determine the frequency of DAT with IDH1 mutations. …”
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    Analysis of Mutant Isocitrate Dehydrogenase 1 Immunoexpression, Ki-67 and Programmed Death Ligand 1 in Diffuse Astrocytic Tumours : Study of Single Center in Bandung, Indonesia
  10. 1270
    “…This study aimed to estimate the prevalence of IDH in adolescents and to explore the impact of IDH in childhood on adult subclinical target organ damage (STOD). …”
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    Isolated diastolic hypertension in childhood and risk of adult subclinical target organ damage: a 30-year prospective cohort study
  11. 1271
    “…Objectives: To estimate the frequency of intradialytic hypertension (IDH) in our centre as per the definition suggested by Kidney Disease: Improving Global Outcomes (KDIGO). …”
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    Frequency of Intradialytic Hypertension Using Kidney Disease: Improving Global Outcomes (KDIGO) Suggested Definition in a Single Hemodialysis Centre in Pakistan
  12. 1272
    “…PURPOSE: This study aimed to investigate the uptake characteristics of (18)F-fluoromisonidazole (FMISO), in mutant-type isocitrate dehydrogenase (IDH-mutant, grade 3 and 4) and wild-type IDH (IDH-wildtype, grade 4) 2021 WHO classification adult-type diffuse gliomas. …”
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    Evaluation of isocitrate dehydrogenase mutation in 2021 world health organization classification grade 3 and 4 glioma adult-type diffuse gliomas with 18F-fluoromisonidazole PET
  13. 1273
    “…Amide/amine ratio and amine levels differentiated IDH-wild type from IDH-mutant (p < 0.0045) and from IDH-mutant_1p/19q(ret) (p < 0.021). …”
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    CEST MRI provides amide/amine surrogate biomarkers for treatment-naïve glioma sub-typing
  14. 1274
    “…The purpose of this study was to evaluate the use of MR Fingerprinting as a radiogenomic marker to differentiate gliomas according to the genotypic marker isocitrate dehydrogenase (IDH) mutation. Based on the results of this study MR Fingerprinting seems to have the potential to differentiate IDH-mutant from IDH-wildtype gliomas, which provides a prognostic factor noninvasively. …”
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    MR Fingerprinting—A Radiogenomic Marker for Diffuse Gliomas
  15. 1275
    “…RESULTS: Compared to patients with infrequent IDH at baseline, those with frequent IDH had significantly lower scores on the symptoms and discomfort of kidney disease dimension at all follow-up points (P < 0.05). …”
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    Impact of frequent intradialytic hypotension on quality of life in patients undergoing hemodialysis
  16. 1276
    “…RESULTS: Data from total of 79 patients which were 42 cases of IDH wild type glioblastoma, 2 cases of IDH mutated glioblastoma, 9 cases of IDH wild type astrocytoma, 13 cases of IDH mutated astrocytoma and 13 cases of IDH mutated and 1p/19q co-deleted oligodendroglioma were included in this study. …”
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    NI-15 THE USEFULNESS OF PET IMAGING IN MOLECULAR DIAGNOSIS OF GLIOMA
  17. 1277
    “…Results: The rHGGs included 10 glioblastoma, IDH1/2-wildtype (GBM, IDH1/2-WT: 45.5%), 3 GBM, IDH1/2-mutant (GBM, IDH1/2-Mut: 13.6%), 7 anaplastic oligodendroglioma, IDH1/2-Mut/codel (AO, IDH1/2-Mut/codel: 31.8%), 1 anaplastic astrocytoma, IDH1/2-WT (AA, IDH1/2-WT: 4.5%), 1 high-grade astrocytoma, IDH1/2-WT (4.5%). …”
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    STMO-17 Treatment outcome of photodynamic therapy using talaporfin sodium for recurrent high-grade glioma
  18. 1278
    “…For patients exhibiting IDH, the iHD sessions delayed successful weaning from RRT (OR, 0.62; 95% CI, 0.43–0.90) compared with sessions on those without IDH. …”
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    Impact of intradialytic hypotension on mortality following the transition from continuous renal replacement therapy to intermittent hemodialysis
  19. 1279
    “…METHODS: We retrospectively analyzed astrocytic tumors, including 18 grade II astrocytomas (isocitrate dehydrogenase (IDH)-mutant: IDH-wildtype = 8:10) and 56 grade III anaplastic astrocytomas (37:19). …”
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    Differentiation of astrocytoma between grades II and III using a combination of methionine positron emission tomography and magnetic resonance spectroscopy
  20. 1280
    por Pearl, Hannah, Fleischer, Candace C.
    Publicado 2023
    “…While mutations in IDH enzymes result in the well‐characterized production of oncometabolite 2‐hydroxyglutarate, dysregulation of other metabolites in IDH tumors is less characterized. …”
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    Association between altered metabolism and genetic mutations in human glioma
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