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1281por Hattori, Natsuki, Hirose, Yuichi, Sasaki, Hikaru, Nakae, Shunsuke, Hayashi, Saeko, Ohba, Shigeo, Adachi, Kazuhide, Hayashi, Takuro, Nishiyama, Yuya, Hasegawa, Mitsuhiro, Abe, Masato“…The gain of whole chromosome 7 (+7) and loss of 10q (−10q) were detected in IDH wild‐type tumors. Kaplan–Meier estimates for progression‐free survival showed that the tumors with mutant IDH, −1p/19q, or +7q (in the absence of +7p) survived longer than tumors with wild‐type IDH, +7, or −10q. …”
Publicado 2016
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1282por Wang, Peng-Fei, Meng, Zhe, Song, Hong-Wang, Yao, Kun, Duan, Ze-Jun, Li, Shou-Wei, Yan, Chang-Xiang“…Moreover, the plasma fibrinogen level was the highest in the subtype of IDH-1(R132H) wildtype - ATRX expression, which showed a shorter OS compared to the group of IDH-1(R132H) mut and IDH-1(R132H) wildtype - ATRX loss (p = 0.001, log-rank test). …”
Publicado 2018
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1283por Gittleman, Haley, Cioffi, Gino, Chunduru, Pranathi, Molinaro, Annette M, Berger, Mitchel S, Sloan, Andrew E, Barnholtz-Sloan, Jill S“…BACKGROUND: In 2016, the World Health Organization reclassified the definition of glioblastoma (GBM), dividing these tumors into isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant GBM, where the vast majority of GBMs are IDH-wild-type. …”
Publicado 2019
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1284por Mahajan, Shiwani, Zhang, Danwei, He, Siyun, Lu, Yuan, Gupta, Aakriti, Spatz, Erica S., Lu, Jiapeng, Huang, Chenxi, Herrin, Jeph, Liu, Shuling, Yang, Jingwei, Wu, Chaoqun, Cui, Jianlan, Zhang, Qiuli, Li, Xi, Nasir, Khurram, Zheng, Xin, Krumholz, Harlan M., Li, Jing“…BACKGROUND: Characterizing and assessing the prevalence, awareness, and treatment patterns of patients with isolated diastolic hypertension (IDH) can generate new knowledge and highlight opportunities to improve their care. …”
Publicado 2019
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1285por Deguchi, Shoichi, Oishi, Takuma, Mitsuya, Koichi, Kakuda, Yuko, Endo, Masahiro, Sugino, Takashi, Hayashi, Nakamasa“…T2-FLAIR mismatch sign was found in 10 (45%) out of 22 patients with IDH-mutant astrocytoma, 1 (5%) out of 20 with oligodendroglioma, and 1 (5%) out of 22 with IDH-wild-type astrocytoma. …”
Publicado 2020
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1286“…Background: Isocitrate dehydrogenase (IDH) mutant is one of the most robust and important genetic aberrations in glioma. …”
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1287por Xie, Yan, Li, Shihui, Shen, Nanxi, Gan, Tongjia, Zhang, Shun, Liu, Weiyin Vivian, Zhu, Wenzhen“…Each parameter was compared between IDH1-mutant and IDH1 wild-type groups by Mann–Whitney U test in lower-grade gliomas (LrGGs) and glioblastomas (GBMs), respectively. …”
Publicado 2021
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1288por Zhang, Shiru, Liu, Sitong, Jiao, Yundi, Zheng, Liqiang, Sun, Yingxian, Sun, Zhaoqing“…Multivariate Cox models were used to evaluate the association of IDH with CVD risk. The authors analyzed 19 688 participants (7140 participants with IDH) according to the ACC/AHA guideline. …”
Publicado 2021
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1289“…Intradialytic hypotension (IDH) is a common side effect that occurs during hemodialysis and poses a great risk for dialysis patients. …”
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1290por Gupta, Puneet, Sarkar, Prattay G., Verma, Vivek, Kumar, Amit, Arora, Sameer, Kotwal, Atul, Raj, Sonika, Goel, Sonu, Malhotra, Sumit“…AIM: To estimate the ISH and IDH from a nationally representative survey of India. …”
Publicado 2022
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1291por Di Nunno, Vincenzo, Aprile, Marta, Gatto, Lidia, Tosoni, Alicia, Ranieri, Lucia, Bartolini, Stefania, Franceschi, Enrico“…SIMPLE SUMMARY: In the present review, we reported the main findings describing tumor-associated microenvironment in patients with IDH mutated and wild-type gliomas. We also focused on the main differences between microenvironment composition reporting data about the microenvironment of pilocytic astrocytomas and IDH wt H3 altered gliomas. …”
Publicado 2023
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1292“…It is produced by two different genes: IDH1 and IDH2. Ivosidenib has been associated with IDH1 inhibition and has been studied in numerous cancers. …”
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1293por Takahashi, Yoshinobu, Nakamura, Hideo, Makino, Keishi, Hide, Takuichiro, Muta, Daisuke, Kamada, Hajime, Kuratsu, Jun-ichi“…RESULTS: In Group 1, patients with IDH1 mutations exhibited a significantly longer survival time than patients with wild-type IDH1. …”
Publicado 2013
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1294“…RESULTS: In this study, we applied PAM on a training set of diffuse gliomas derived from The Cancer Genome Atlas (TCGA) and identified DNA methylation signatures to classify LGG IDH wild type from LGG IDH mutant, LGG IDH mutant with 1p/19q codeletion from LGG IDH mutant with intact 1p/19q loci and GBM IDH wild type from GBM IDH mutant with an accuracy of 99–100%. …”
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1295“…RESULTS: A significant difference (p = 0,0037) between the central region of IDH-mutated tumors (356,83 ± 114,97 ms) and the IDH-wildtype (199,92 ± 53,13 ms) was found. …”
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1296por Ball, Matthew K, Kollmeyer, Thomas M, Praska, Corinne E, McKenna, Michelle L, Giannini, Caterina, Raghunathan, Aditya, Jentoft, Mark E, Lachance, Daniel H, Kipp, Benjamin R, Jenkins, Robert B, Ida, Cristiane M“…BACKGROUND: Oligodendroglioma is genetically defined by concomitant IDH (IDH1/IDH2) mutation and whole-arm 1p/19q codeletion. …”
Publicado 2020
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1297por Miyake, Keisuke, Fujimori, Takeshi, Toyota, Yasunori, Ogawa, Daisuke, Hatakeyama, Tetsuhiro, Okauchi, Masanobu, Kawanishi, Masahiko, Tamiya, Takashi“…Results: In glioma, the cutoff MET L/N ratios to distinguish between IDH-mut and Codel, IDH-mut and GBM, Codel and GBM, and IDH-wt and GBM were 3.61, 4.42, 4.92, and 4.33, respectively, and the cutoff FLT L/N ratios to distinguish between IDH-mut and IDH-wt, IDH-mut and GBM, Codel and GBM, and IDH-wt and GBM were 3.43, 6.46, 3.39, and 7.56, respectively. …”
Publicado 2020
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1298“…METHODS: Five live human gliomas (2 oligos; 2 IDH-WT GBMs; 1 IDH-mutant GBM), were evaluated in situ with high molecular weight (100kDA) intraoperative microdialysis using 3 disparately placed catheters. …”
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1299por Snauwaert, Evelien, Wagner, Stéphanie, Jawa, Natasha A., Bruno, Valentina, McKay, Ashlene, Kirpalani, Amrit, Nemec, Rosaleen, Teoh, Chia Wei, Harvey, Elizabeth A., Zappitelli, Michael, Licht, Christoph, Noone, Damien G.“…BACKGROUND: Intra-dialytic hypotension (IDH) is the most common serious adverse event in paediatric haemodialysis (HD). …”
Publicado 2021
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1300por Pusch, Stefan, Schweizer, Leonille, Beck, Ann-Christin, Lehmler, Johanna-Marie, Weissert, Susanne, Balss, Jörg, Miller, Aubry K, von Deimling, Andreas“…In gliomas, the frequency of IDH1 mutations in codon 132 increases in the order R132L-R132S-R132G-R132C-R132H with R132H constituting more than 90% of all IDH1 mutations. …”
Publicado 2014
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