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Mostrando 121 - 140 Resultados de 4,168 Para Buscar '"IDH"', tiempo de consulta: 0.11s Limitar resultados
  1. 121
    “…Three patients had concurrent IDH1 and IDH2 mutations. The R140 IDH2 mutant has not been reported to date in CHS patients. …”
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    IDH1/2 Mutations Predict Shorter Survival in Chondrosarcoma
  2. 122
    “…INTRODUCTION: Chondrosarcoma is a malignant cartilage-forming bone tumour in which mutations in IDH1 and IDH2 frequently occur. Previous studies suggest an increased dependency on glutaminolysis in IDH1/2 mutant cells, which resulted in clinical trials with the drugs CB-839, metformin and chloroquine. …”
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    Targeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation
  3. 123
    “…However, about 20% of glioblastomas lack alterations in TERTp and IDH. These tumors, designated TERTp(WT)-IDH(WT) glioblastomas, do not have well-established genetic biomarkers or defined mechanisms of telomere maintenance. …”
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    The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma
  4. 124
    “…The first FDA approved IDH2 inhibitor was enasidenib in 2017. In addition, IDH1 inhibitors are in ongoing clinical studies, and the oral BCL-2 inhibitor venetoclax shows preliminary efficacy in this subset of patients. …”
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    Evolving Treatment Strategies for Elderly Leukemia Patients with IDH Mutations
  5. 125
    “…Mutations in the isocitrate dehydrogenase (IDH mut) gene have gained paramount importance for the prognosis of glioma patients. …”
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    Predicting IDH genotype in gliomas using FET PET radiomics
  6. 126
    “…Mutation or transcriptional up-regulation of isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) promotes cancer progression through metabolic reprogramming and epigenetic deregulation of gene expression. …”
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    IDH3α regulates one-carbon metabolism in glioblastoma
  7. 127
    “…The transcriptome-radiomic analysis revealed that these features were associated with the immune response, biological adhesion, and several malignant behaviors, all of which are consistent with biological processes that are differentially expressed in IDH wild type and IDH mutant LGGs. Finally, a prognostic signature showed an ability to stratify IDH mutant LGGs into high and low risk groups with distinctive outcomes. …”
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    IDH mutation-specific radiomic signature in lower-grade gliomas
  8. 128
    por Bergaggio, Elisa, Piva, Roberto
    Publicado 2019
    “…The discovery of IDH1 and IDH2 mutations in several malignancies has brought to the approval of drugs targeting IDH1/2 mutants in cancers. …”
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    Wild-Type IDH Enzymes as Actionable Targets for Cancer Therapy
  9. 129
    por Huang, L Eric
    Publicado 2019
    “…Thus, novel inhibitors of mutant IDH1 have been developed for therapeutic targeting. …”
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    Friend or foe—IDH1 mutations in glioma 10 years on
  10. 130
    “…The metabolic enzyme isocitrate dehydrogenase 1 (IDH1) catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG). …”
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    IDH1 fine-tunes cap-dependent translation initiation
  11. 131
    “…Compared to the IDH wild group, the IDH mutant group was significantly younger and mean follow-up time was longer. …”
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    MPC-05 TUMOR RELATED EPILEPSY AND IDH MUTATIONS IN GLIOMAS
  12. 132
    “…Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate and therefore play key roles in the Krebs cycle and cellular homoeostasis. …”
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    IDH mutation in glioma: molecular mechanisms and potential therapeutic targets
  13. 133
    “…Despite our extensive knowledge regarding IDH mutations in intracranial tumors, mutations of this gene in spinal cord astrocytomas remain poorly understood. …”
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    Rare Cases of IDH1 Mutations in Spinal Cord Astrocytomas
  14. 134
    “…Of the 195 patients with CC, six (3.13%) were found to exhibit IDH1 (n = 5) or IDH2 (n = 1) mutations. Among patients with IDH1 mutations, four had R132C (c.394C>T) and one had R132G (c.394C>G) mutations. …”
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    Frequency and Prognostic Value of IDH Mutations in Korean Patients With Cholangiocarcinoma
  15. 135
    por Li, Xiaozhi, Meng, Yutong
    Publicado 2020
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    Analyses of metastasis-associated genes in IDH wild-type glioma
  16. 136
    “…INTRODUCTION: The incidence of IDH mutations in pediatric glioma is unclear. Recent publications suggest rates ranging between 0–20%. …”
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    LGG-03. INCIDENCE AND OUTCOME OF PEDIATRIC IDH-MUTANT GLIOMA
  17. 137
    “…SIMPLE SUMMARY: Cartilage tumors frequently harbor mutations in the isocitrate dehydrogenase (IDH1 or IDH2) genes. These mutations cause an increase in the levels of the oncometabolite D-2-hydroxyglutarate (D-2-HG), which leads to widespread changes in several cellular processes, including the epigenetic landscape. …”
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    Beyond the Influence of IDH Mutations: Exploring Epigenetic Vulnerabilities in Chondrosarcoma
  18. 138
    “…Ivosidenib is the first approved oral, targeted, small-molecule inhibitor of the isocitrate dehydrogenase 1 (IDH1) mutation seen in AML. IDH1 mutations have been associated with significantly worse outcomes in disease-free survival, relapse-free survival, and overall survival (NCCN, 2018). …”
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    Ivosidenib: IDH1 Inhibitor for the Treatment of Acute Myeloid Leukemia
  19. 139
    “…NLR showed significant p value in differentiating IDH wild from IDH mutant GBM. Conclusion  dNLR has the maximum diagnostic value in diagnosing glioma from other tumors. …”
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    Peripheral Inflammatory Blood Markers in Diagnosis of Glioma and IDH Status
  20. 140
    “…Thus, inhibition of mutant IDH is considered a potential therapeutic target. …”
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    Early Noninvasive Metabolic Biomarkers of Mutant IDH Inhibition in Glioma
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