“…Mutations in IDH1 and IDH2 are associated with significant increase in progression free survival and overall survival. …”
Enlace del recurso
Enlace del recurso

“…BACKGROUND: The Human T cell lymphotropic virus type 1 (HTLV-1)-associated infective dermatitis (IDH), is a chronic relapsing dermatitis which usually presents in children older than 2 years. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We conducted a study to determine whether the hemocontrol biofeedback system (HBS) can improve intradialytic hypotension (IDH) in hypotension-prone hemodialysis (HD) patients compared with conventional HD. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Isocitrate dehydrogenase (IDH) mutation and 1p/19q-codeletion are oncogenetic alterations with a positive prognostic value for diffuse gliomas, especially grade II and III. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Group comparisons revealed that the ALPS index of grade II/III gliomas was significantly higher than that of grade IV gliomas (p < 0.001). The ALPS index of IDH1 mutant gliomas was significantly higher than that of IDH1 wild-type gliomas (p < 0.001). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: IDH-mutant tumors exhibited few unique recurrent substitutions—all in coding regions, while IDH wild-type tumors exhibited many substitutions in non-coding regions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: The significant difference in prognosis between IDH1 wild-type and IDH1 mutant glioblastoma multiforme (GBM) may be attributed to their metabolic discrepancies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…World Health Organization tumor classifications of the central nervous system differentiate glioblastoma multiforme (GBM) into wild-type (WT) and mutant isocitrate dehydrogenase (IDH) genotypes. This study proposes a noninvasive computer-aided diagnosis to interpret the status of IDH in glioblastomas from transformed magnetic resonance imaging patterns. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…While the traditional grading system has failed to stratify the risk of IDH-mutant astrocytoma, canonical histological and proliferative markers may be applicable to the risk stratification of IDH-wildtype astrocytoma. …”
Enlace del recurso
Enlace del recurso

“…Yet, 95% of glioblastoma are IDH wild-type. Here, we review current knowledge about IDH wild-type enzymes and their putative role in mechanisms driving tumor progression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Three main molecular types (H3.3 mutant, IDH mutant, and H3.3/IDH wild-type) and a number of subtypes have been identified. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Neurotransmitter-based unsupervised clustering identified three established glioma molecular subgroups that parallel major World Health Organization glioma subclasses (IDH-wildtype astrocytomas, IDH-mutant astrocytomas, IDH-mutant oligodendroglioma). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We applied the drug affinity responsive target stability approach to show that Silybin binds to isocitrate dehydrogenase 1 (IDH1). This combination leads to reduced phosphorylation of IDH1 and inhibits enzyme activity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the new WHO classification 2021, adult-type diffuse astrocytic gliomas subdivide into isocitrate dehydrogenase (IDH)-mutant astrocytoma, IDH-mutant and 1p/19q-codeleted oligodendroglioma, and IDH-wildtype glioblastoma. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this review, we highlight novel findings on the intratumoral heterogeneity of IDH-wildtype and IDH-mutant gliomas characterized at single-cell resolution, and emphasize the mechanisms shaping the immune TME and therapeutic implications. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The diagnostic and prognostic potential of an onco-metabolite, 2-hydroxyglutarate (2HG) as a proton magnetic resonance spectroscopy (1H-MRS) detectable biomarker of the isocitrate dehydrogenase (IDH)-mutated (IDH-MT) gliomas has drawn attention of neuroradiologists recently. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Mutations in isocitrate dehydrogenase (IDH) 1 and 2, found in the majority of adult diffuse low-grade glioma (DLGG), seem to relate to a favorable prognosis compared to IDH wild-type (IDH-wt) counterparts. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Twelve healthy stallions, n.6 American Quarter Horse (AQH) and n.6 Italian Draft Horse (IDH) stallions, regularly used for artificial insemination, were included in the study. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Two others (PDHB subunit and IDH3A subunit) did not appear to bind to OMI, however persisted in the mito-proteome when OMI was inhibited. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Intradialytic hypotension (IDH) is a global public health problem. A rising number of IDH sufferers resort to Chinese patent medicine, Shengmai Injection (SMI) in China. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso