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  1. 1461
    “…Moreover, two key metabolic enzymes, isocitrate dehydrogenases (IDH1/2), are mutated in more than 15% of AML patient, reinforcing the interest in studying metabolic reprogramming, in particular in this subgroup of patients. …”
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    Stable Isotope Labeling Highlights Enhanced Fatty Acid and Lipid Metabolism in Human Acute Myeloid Leukemia
  2. 1462
    “…By blocking IDH2, we confirmed that IDH2 is a potential target for the inhibition of tumor cell growth and tumor secretion. …”
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    Metabolic profiling reveals distinct metabolic alterations in different subtypes of pituitary adenomas and confers therapeutic targets
  3. 1463
    “…Isocitrate dehydrogenase (IDH) is an oncogene, and the expression of a mutated IDH promotes cell proliferation and inhibits cell differentiation. …”
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    Screening of Methylation Signature and Gene Functions Associated With the Subtypes of Isocitrate Dehydrogenase-Mutation Gliomas
  4. 1464
    “…METHODS: Thirty-six patients were categorized as haemodynamically stable, asymptomatic IDH or unstable (symptomatic IDH) according to their changes in systolic blood pressure and associated clinical symptoms. …”
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    Monitoring transcellular fluid shifts during episodes of intradialytic hypotension using bioimpedance spectroscopy
  5. 1465
    “…TERT mutation is preferentially present in glioblastoma and IDH-wt gliomas and is associated with poor prognosis. …”
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    TERT Mutation Is Accompanied by Neutrophil Infiltration and Contributes to Poor Survival in Isocitrate Dehydrogenase Wild-Type Glioma
  6. 1466
    “…Isocitrate dehydrogenase (IDH) wild-type diffuse astrocytic tumors tend to be pathologically diagnosed as glioblastomas (GBMs). …”
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    Myoinositol to Total Choline Ratio in Glioblastomas as a Potential Prognostic Factor in Preoperative Magnetic Resonance Spectroscopy
  7. 1467
    “…In astrocytic tumors, p53 can act as a surrogate marker. IDH-mutant glioma patients have better prognoses than IDH wild gliomas.…”
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    Clinicopathological Correlation of Glioma Patients with respect to Immunohistochemistry Markers: A Prospective Study of 115 Patients in a Tertiary Care Hospital in North India
  8. 1468
    “…Multi-tyrosine kinase inhibitors, such as regorafenib, also showed efficacy in the setting of recurrent glioblastoma. IDH inhibitors are currently in the advanced phase of clinical evaluation for patients with IDH-mutant gliomas. …”
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    Innovating Strategies and Tailored Approaches in Neuro-Oncology
  9. 1469
    “…Mutant isocitrate dehydrogenase (IDH) 2 “IDH2m” acquires a neo-enzymatic activity reducing α-ketoglutarate to an oncometabolite, D-2-hydroxyglutarate (2-HG). …”
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    Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents
  10. 1470
    “…As a unique resistance mechanism the mutated IDH isotype may switch from IDH1 to IDH2 or vice versa. …”
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    Resistance to targeted therapies in acute myeloid leukemia
  11. 1471
    “…Isocitrate dehydrogenase 1 (IDH1) naturally copurifies and crystallizes in a resting state with a molecule of its exchangeable cofactor, NADP(+)/NADPH, bound in each monomer of the homodimer. …”
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    NADP(H)-dependent biocatalysis without adding NADP(H)
  12. 1472
    “…ABSTRACT: Diffuse infiltrating low-grade glioma (LGG) is classified as WHO grade 2 astrocytoma with isocitrate dehydrogenase (IDH) mutation and oligodendroglioma with IDH1 mutation and 1p/19q codeletion. …”
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    Preclinical Models of Low-Grade Gliomas
  13. 1473
    “…Background: The association between isolated diastolic hypertension (IDH) and cardiovascular events has been inconsistently reported. …”
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    Isolated Diastolic Hypertension and Risk of Cardiovascular Events: A Systematic Review and Meta-Analysis of Cohort Studies With 489,814 Participants
  14. 1474
    “…SIMPLE SUMMARY: Molecularly targeted therapy is now a standard treatment option for patients with acute myeloid leukemia and IDH1/2 or FLT3 mutations. This review summarizes the current treatment landscape of IDH and FLT3 inhibitors and emerging targeted therapies for the treatment of AML. …”
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    Molecularly Targeted Therapy in Acute Myeloid Leukemia: Current Treatment Landscape and Mechanisms of Response and Resistance
  15. 1475
    “…The intermediate disturbance hypothesis (IDH) and the dynamic equilibrium model (DEM) are influential theories in ecology. …”
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    Disturbance–diversity models: what do they really predict and how are they tested?
  16. 1476
    “…Somatic mutation of Isocitrate dehydrogenase 1 (IDH1) at the locus of R132 (IDH1(R132H)) occurs in > 70% of WHO grade II-III gliomas and secondary glioblastomas. …”
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    Isocitrate dehydrogenase 1R132H mutation in microglia/macrophages in gliomas: Indication of a significant role of microglia/macrophages in glial tumorigenesis
  17. 1477
    “…Both dynamic and static FET PET parameters may assist in predicting the IDH mutational status, but time to peak derived from dynamic data may be a better predictor for IDH status. …”
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    Dynamic 18F-Fluoro-Ethyl-Tyrosine Positron Emission Tomography/ Computed Tomography: A Better Predictor of Isocitrate Dehydrogenase Mutation in Presurgical Evaluations of Glioma
  18. 1478
    “…Here, we show that MYC transcriptionally activates IDH2 and increases alpha-ketoglutarate (αKG) levels. …”
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    MYC, mitochondrial metabolism and O-GlcNAcylation converge to modulate the activity and subcellular localization of DNA and RNA demethylases
  19. 1479
    “…We defined, based on TERTp-mut and IDH mutation status, four prognostic groups: (1) TERTp-mut and IDH-mut associated with 1p19q codeletion, overall survival (OS)>17 years; (2) TERTp-wt and IDH-mut, associated with TP53 mutation, OS=97.5 months; (3) TERTp-wt and IDH-wt, with no specific association, OS=31.6 months; (4) TERTp-mut and IDH-wt, associated with EGFR amplification, OS=15.4 months. …”
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    TERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations
  20. 1480
    “…The secondary end point was to evaluate frequency of 1p/19q codeletion, IDH 1 mutation, ATRX deletion and p53 in HGG patients. …”
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    Correlation of Molecular Markers in High Grade Gliomas with Response to Chemo-Radiation
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