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  1. 1541
    “…BACKGROUND AND PURPOSE: Intradural disc herniation (IDH) can manifest with radicular or medullary syndrome. …”
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    Diagnostic approach, therapeutic strategies, and surgical indications in intradural thoracic disc herniation associated with CSF leak, intracranial hypotension, and CNS superficial siderosis
  2. 1542
    “…We have performed genome-wide DNA methylation arrays and mutational analysis of TET2, IDH1, IDH2, EZH2 and JAK2 in a group of 24 patients with CMML. 249 genes were differentially methylated between CMML patients and controls. …”
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    TET2 Mutations Are Associated with Specific 5-Methylcytosine and 5-Hydroxymethylcytosine Profiles in Patients with Chronic Myelomonocytic Leukemia
  3. 1543
    “…RESULTS: Samples with point mutations (BRAF, IDH1 and NRAS) show a decrease in MLH1 expression when compared to negative samples. …”
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    Correlation of MLH1 and MGMT expression and promoter methylation with genomic instability in patients with thyroid carcinoma
  4. 1544
    “…In oligodendroglial tumors, it was strongly associated with both IDH1/IDH2 mutations and total 1p/19q codeletion and inversely with EGFR gene amplification. …”
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    Promoter Hypermethylation of the EMP3 Gene in a Series of 229 Human Gliomas
  5. 1545
    “…The present study suggests that IDH2 and α-ketoglutarate may be potential new targets for the prevention and treatment of liver fibrosis.…”
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    The mechanism and role of intracellular α-ketoglutarate reduction in hepatic stellate cell activation
  6. 1546
    “…Maffucci syndrome is characterized by multiple hemangiomas and enchondromas. Somatic mutations in IDH1 and IDH2 are associated with the development of Maffucci syndrome, and these patients develop various malignant nonskeletal tumors in addition to malignant skeletal tumors. …”
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    Maffucci Syndrome with Intrahepatic Cholangiocarcinoma: A Case Report
  7. 1547
    “…Here, we present a case of IDH in a young boy living in Buenos Aires with symptoms since 2010, at the age of 5. …”
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    Case Report: Relevance of an Accurate Diagnosis and Monitoring of Infective Dermatitis Associated With Human T-Lymphotropic Virus Type 1 in Childhood
  8. 1548
    “…However, there was a substantial heterogeneity in the DNMT3a and IDH studies. In conclusion epigenetic mutations in ASXL1, TET2, DNMT3a and IDH adversely impact OS in patients with AML albeit with considerable heterogeneity and possibly publication bias. …”
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    Impact of mutations in epigenetic modifiers in acute myeloid leukemia: A systematic review and meta-analysis
  9. 1549
    “…Glioblastoma (GBM) is one of the most aggressive forms of cancer. Although IDH1 mutation indicates a good prognosis and a potential target for treatment, most GBMs are IDH1 wild-type. …”
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    Metabolic Modeling Identifies a Novel Molecular Type of Glioblastoma Associated with Good Prognosis
  10. 1550
    por Arita, Hideyuki, Yamasaki, Kai, Matsushita, Yuko, Nakamura, Taishi, Shimokawa, Asanao, Takami, Hirokazu, Tanaka, Shota, Mukasa, Akitake, Shirahata, Mitsuaki, Shimizu, Saki, Suzuki, Kaori, Saito, Kuniaki, Kobayashi, Keiichi, Higuchi, Fumi, Uzuka, Takeo, Otani, Ryohei, Tamura, Kaoru, Sumita, Kazutaka, Ohno, Makoto, Miyakita, Yasuji, Kagawa, Naoki, Hashimoto, Naoya, Hatae, Ryusuke, Yoshimoto, Koji, Shinojima, Naoki, Nakamura, Hideo, Kanemura, Yonehiro, Okita, Yoshiko, Kinoshita, Manabu, Ishibashi, Kenichi, Shofuda, Tomoko, Kodama, Yoshinori, Mori, Kanji, Tomogane, Yusuke, Fukai, Junya, Fujita, Koji, Terakawa, Yuzo, Tsuyuguchi, Naohiro, Moriuchi, Shusuke, Nonaka, Masahiro, Suzuki, Hiroyoshi, Shibuya, Makoto, Maehara, Taketoshi, Saito, Nobuhito, Nagane, Motoo, Kawahara, Nobutaka, Ueki, Keisuke, Yoshimine, Toshiki, Miyaoka, Etsuo, Nishikawa, Ryo, Komori, Takashi, Narita, Yoshitaka, Ichimura, Koichi
    Publicado 2016
    “…The prognostic impact of TERT mutations has been controversial in IDH-wild tumors, particularly in glioblastomas (GBM). …”
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    A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas
  11. 1551
    “…Group 1 (n = 7) harbored known hotspot mutations in Histone 3 (H3) (K27M or G34V) or IDH1 (H3/IDH1 mutants) and co-occurring TP53 or ACVR1 mutations in tumor pairs across the disease course. …”
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    Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas
  12. 1552
    “…Albumin infusion before and during therapy has been used for treating IDH with the varying results. We evaluated the efficacy of albumin infusion in preventing IDH during IHD in hypoalbuminemic inpatients. …”
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    A randomized trial of albumin infusion to prevent intradialytic hypotension in hospitalized hypoalbuminemic patients
  13. 1553
    “…Thus, age is an important consideration in the clinical management of adults with IDH.…”
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    Isolated Diastolic Hypertension in the IDACO Study: An Age-Stratified Analysis Using 24-Hour Ambulatory Blood Pressure Measurements
  14. 1554
    “…In IDH lesions loss of heterozygosity (LOH) at various loci could be identified, and comparative genomic hybridization (CGH) and fluorescence in situhybridization (FISH) studies delivered evidence for DNA amplification on chromosomal region 20q13 in the early stage of IDH. …”
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    Genetic Alterations in Presumptive Precursor Lesions of Breast Carcinomas
  15. 1555
    “…Enasidenib is an FDA-approved isocitrate dehydrogenase 2 (IDH2) inhibitor, which is used in the treatment of acute myeloid leukemia (AML). …”
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    Thyroiditis: A Rare Manifestation of Enasidenib-Induced Differentiation Syndrome
  16. 1556
    por Zhang, Wei, Liu, Bei, Wu, Shiwen, Zhao, Li
    Publicado 2023
    “…ELISA assay confirmed that patients with poor-risk AMLs had higher levels of IDH2, ENO1, and FH compared with intermediate-risk AML patients. …”
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    TMT-based comprehensive proteomic profiling identifies serum prognostic signatures of acute myeloid leukemia
  17. 1557
    “…The aim of the study was to investigate cognitive functioning in a cohort of patients with high grade glioma, according to isocitrate dehydrogenase (IDH) and methyl guanine methyl transferase (MGMT) status and other clinical characteristics. …”
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    Cognitive functioning in a cohort of high-grade glioma patients
  18. 1558
    “…The new 2021 WHO classification divides adult HGG into four subtypes: grade 3 oligodendroglioma (1p/19 codeleted, IDH-mutant); grade 3 IDH-mutant astrocytoma; grade 4 IDH-mutant astrocytoma, and grade 4 IDH wild-type glioblastoma (GB). …”
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    SEOM-GEINO clinical guidelines for high-grade gliomas of adulthood (2022)
  19. 1559
    “…SNP-A karyotyping was applied to identify recurrent areas of loss of heterozygosity and bidirectional sequencing was performed to evaluate the mutational status of TET2, DNMT3A, ASXL1, EZH2, IDH1/IDH2 and the CBL gene family. Overall survival (OS) was analyzed using the Kaplan-Meier method. …”
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    Single Nucleotide Polymorphism Array Lesions, TET2, DNMT3A, ASXL1 and CBL Mutations Are Present in Systemic Mastocytosis
  20. 1560
    “…Two of the signature genetic events that occur in human gliomas, EGFR amplification and IDH mutation, are poorly represented in experimental models in vitro. …”
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    Tumor versus Stromal Cells in Culture—Survival of the Fittest?
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