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  1. 1561
    por Kim, Na Rae, Kim, Hyeon Chang
    Publicado 2015
    “…RESULTS: In 2012, approximately 9.5 million adults were estimated to have hypertension, which consists of 5675671 TH (60.0%), 954253 ISH (10.1%), 1649486 IDH (17.4%), and 1175506 SDH (12.4%). Between 2010 and 2012, the proportion of IDH steadily decreased with age, but ISH increased especially in older ages (≥40). …”
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    Prevalence and Trends of Isolated Systolic Hypertension among Korean Adults: the Korea National Health and Nutrition Examination Survey, 1998-2012
  2. 1562
    “…BACKGROUND: Geriatric glioblastoma (GBM) patients have a poorer prognosis than younger patients, but IDH1/2 mutations (more common in younger patients) confer a favorable prognosis. …”
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    GBM-associated mutations and altered protein expression are more common in young patients
  3. 1563
    “…Transcription levels of SIRT3, AMPK, CPT-1A, IDH2, MnSOD and protein expression level of SIRT3 were measured by real-time PCR and Western blotting, respectively. …”
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    Curcumin enhances liver SIRT3 expression in the rat model of cirrhosis
  4. 1564
    “…In fact, genes involved in DNA demethylation (such as DNMT3A, TET2, IDH1, and IDH2) or histone methylation and demethylation (EZH2, MLL, DOT1L) are frequently mutated in primary and secondary AML. …”
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    Targeting histone methyltransferase and demethylase in acute myeloid leukemia therapy
  5. 1565
    “…Notably, 29 GBMOs could be reclassified into 11 cases of GBM, IDH-mutant, 16 cases of GBM, IDH-wildtype, and two cases of anaplastic oligodendroglioma, IDH mutant. …”
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    Reclassification of Mixed Oligoastrocytic Tumors Using a Genetically Integrated Diagnostic Approach
  6. 1566
    “…The determinants of long-term survival in patients with IDH1/2wt GBM, beyond MGMT promoter methylation, remain to be identified, and even the absence of both IDH1/2 mutations and MGMT promoter methylation does not preclude long-term survival. …”
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    Clinical and immunological correlates of long term survival in glioblastoma
  7. 1567
    por Galkin, Maria, Jonas, Brian A
    Publicado 2019
    “…With recent advances in molecular testing, targeting particular leukemogenic mutations such as those occurring in isocitrate dehydrogenase (IDH) became possible. Enasidenib is a new small-molecule inhibitor of mutant isocitrate dehydrogenase-2 (IDH2). …”
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    Enasidenib in the treatment of relapsed/refractory acute myeloid leukemia: an evidence-based review of its place in therapy
  8. 1568
    “…So far, it has not been proven experimentally that the accumulation of D-2-HG in IDH mutant cells is the result of its insufficient degradation by D2HDH. …”
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    Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations
  9. 1569
    “…Multivariate analysis incorporating tumor status based on the presence of IDH mutations, TERT promoter mutations, and 1p/19q codeletion showed that in lower-grade gliomas, high NLR predicted poorer survival for the triple-negative, IDH mutation only, TERT mutation only, and IDH and TERT mutation groups. …”
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    Prognostic value of preoperative hematological markers combined with molecular pathology in patients with diffuse gliomas
  10. 1570
    “…Variability in symptoms and difficulty in interpreting magnetic resonance (MR) images with/without contrast make the diagnosis of an IDH difficult. Here, we reported a patient with an L1–L2 IDH and appropriately reviewed the relevant literature. …”
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    Intradural disc herniation at the L1–L2 level: A case report and literature review
  11. 1571
    “…METHODS: In total, 51 patients were included in this study; 33 supratentorial diffuse glioma (18 diffuse astrocytoma with IDH mutant (IDHmut-Noncodel), 12 oligodendroglioma with IDH-mutant and 1p19q codeletion (IDHmut-Codel), 3 diffuse astrocytoma with IDH wildtype (IDHwt)), 18 diffuse midline glioma and 11 DNT. …”
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    NI-17 T2-FLAIR MISMATCH SIGN IN DIFFUSE GLIOMA AND DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMOR
  12. 1572
    “…Higher contra‐tumoral RSFC was associated with worse cognitive performance in patients, which, however, seemed to apply mainly to IDH‐wildtype patients. The benefit of RSFC alterations for cognitive performance varied depending on the affected hemisphere, cognitive demand, and seemed to be altered by IDH‐mutation status. …”
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    Asymmetric tumor‐related alterations of network‐specific intrinsic functional connectivity in glioma patients
  13. 1573
    “…Lastly, we investigated IDH1-mutated GBMSC mutations that are known to affect mitochondrial and mTORC1 metabolism, and the tight-binding meclizine provoked ‘synthetic lethality’ in IDH1-mutant GBMSCs. …”
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    Novel mTORC1 Inhibitors Kill Glioblastoma Stem Cells
  14. 1574
    “…Significance of mutated IDH1 targeting and a potential role of ivosidenib in AML management, when used either as a single agent or as part of combination therapies, will be reviewed herein.…”
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    Efficacy and Safety Profile of Ivosidenib in the Management of Patients with Acute Myeloid Leukemia (AML): An Update on the Emerging Evidence
  15. 1575
    “…In line with the IDH, species richness showed a hump‐backed temporal course for alpha and gamma diversity. …”
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    Long‐term development of species richness in a central European beech (Fagus sylvatica) forest affected by windthrow—Support for the intermediate disturbance hypothesis?
  16. 1576
    por Shah, Fahad Hassan, Kim, Song Ja
    Publicado 2022
    “…The current study is focused on screening various medicinal compounds against IDH1 and IDH2 combined with insilico gene expression, cancer cells cytotoxicity and ADMET (absorption, distribution, metabolism, excretion and toxicity) studies to elucidate the molecular mechanism against chondrosarcoma and also to uncover pharmacokinetic profile of these compounds. …”
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    Identification of medicinal compounds as potential inhibitors for mutated isocitrate dehydrogenases against chondrosarcoma
  17. 1577
    “…Intriguingly, the transcription factor c-Maf regulates γδT17 effector function through direct regulation of IDH2 promoter activity. Moreover, mTORC2 affects the expression of c-Maf and IDH2 and subsequent IL-17 production in γδ T cells. …”
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    Differential metabolic requirement governed by transcription factor c-Maf dictates innate γδT17 effector functionality in mice and humans
  18. 1578
    “…BACKGROUND: Intradural herniation (IDH) or transdural disc herniation is a rare presentation of lumbar disc disease. …”
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    Intradural disc herniation of L2/3: A case report and literature review
  19. 1579
    “…By comprehensively analyzing mRNA data, we observed that 41 genes were differentially expressed between IDH(MUT) and IDH(WT) LGG patients. A risk signature comprising 10 genes, which could divide samples into high- and low-risk groups of distinct prognoses, was developed and independently validated. …”
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    Identifying α-KG-dependent prognostic signature for lower-grade glioma based on transcriptome profiles
  20. 1580
    “…Intradialytic hypotension (IDH) is an adverse event occurred during hemodialysis (HD) sessions with high morbidity and mortality. …”
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    Intradialytic hypotension prediction using covariance matrix-driven whale optimizer with orthogonal structure-assisted extreme learning machine
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