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  1. 1641
    “…Immunohistochemistry for IDH1-R132H was done on 5-μm thick formalin-fixed, paraffin-embedded tumour sections with the use of an antibody specific for the mutant IDH1-R132H protein. …”
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    Myelin-associated proteins are potential diagnostic markers in patients with primary brain tumour
  2. 1642
    “…METHODS: We used neuronavigation to acquire 133 image-guided and spatially separated stereotactic biopsy samples from 16 adult patients with a diffuse glioma (7 IDH-wildtype and 2 IDH-mutant glioblastoma, 6 diffuse astrocytoma, IDH-mutant and 1 oligodendroglioma, IDH-mutant and 1p19q codeleted), which we characterized using DNA methylation arrays. …”
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    Spatial concordance of DNA methylation classification in diffuse glioma
  3. 1643
    “…Isocitrate dehydrogenase 1 (IDH1) is mutated in > 70% of these tumors, making it an attractive therapeutic target. …”
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    Synergistic anti-tumor efficacy of mutant isocitrate dehydrogenase 1 inhibitor SYC-435 with standard therapy in patient-derived xenograft mouse models of glioma
  4. 1644
    “…Significant differences between IDH1-mutated and IDH1-wildtype gliomas were revealed for maximum, lower percentiles, modus, standard deviation (SD), entropy and skewness. …”
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    Diffusion Weighted Imaging in Gliomas: A Histogram-Based Approach for Tumor Characterization
  5. 1645
    “…METHODS: Digitized whole slide images were downloaded from The Cancer Genome Atlas (TCGA) for 766 diffuse glioma patients, including isocitrate dehydrogenase (IDH)-mutant/1p19q-codeleted oligodendroglioma, IDH-mutant/1p19q-intact astrocytoma, and IDH-wildtype astrocytoma/glioblastoma. …”
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    Prognostic risk stratification of gliomas using deep learning in digital pathology images
  6. 1646
    “…Moreover, the expression of miR204 is increased in mice with IDH2 deficiency. Increased miR204 by IDH2 deficiency regulates carnitine palmitoyltransferase 1a (cpt1a) synthesis, which inhibits fatty acid β-oxidation. …”
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    miR204 potentially promotes non-alcoholic fatty liver disease by inhibition of cpt1a in mouse hepatocytes
  7. 1647
    “…Specifically, diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma (DAG-G) were reclassified as glioblastoma (n = 15). …”
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    Impact of new molecular criteria on diagnosis and survival of adult glioma patients
  8. 1648
    “…CONCLUSIONS: The advanced multiparametric MRI-based glioma score can predict the IDH-mutation status with high statistical significance.…”
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    Advanced multiparametric MRI-based scoring for isocitrate dehydrogenase mutation prediction of gliomas
  9. 1649
    “…IDH1-mutated HCT116 cells released significantly more sEVs than wild-type (WT) cells. …”
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    Metabolomics of small extracellular vesicles derived from isocitrate dehydrogenase 1-mutant HCT116 cells collected by semi-automated size exclusion chromatography
  10. 1650
    “…LGG patients with wild type IDH and with IGFBP7 hypo‐methylation demonstrated even worse prognosis. …”
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    Co‐amplified with PDGFRA, IGFBP7 is a prognostic biomarker correlated with the immune infiltrations of glioma
  11. 1651
    “…The prevalence of intervertebral disc herniation (IDH) of the thoracic spine is rare compared to the cervical or lumbar spine. …”
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    Surgical Treatment of T1-2 Disc Herniation with T1 Radiculopathy: A Case Report with Review of the Literature
  12. 1652
    “…[Image: see text] Isocitrate dehydrogenase is mutated at a key active site arginine residue (Arg172 in IDH2) in many cancers, leading to the synthesis of the oncometabolite (R)-2-hydroxyglutarate (2HG). …”
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    Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes
  13. 1653
    por Wang, Wei, Situ, Guohai
    Publicado 2017
    “…In this article, we propose an interferometric DH PSF (iDH PSF) using two opposed objective lenses as in the 4Pi microscope. …”
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    Interferometric rotating point spread function
  14. 1654
    “…Prevalence of intradialytic hypotension (IDH) can be as high as 20–30%, contributing to subclinical, transient myocardial ischemia. …”
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    Hemodynamic Instability during Dialysis: The Potential Role of Intradialytic Exercise
  15. 1655
    “…Epigenetic modifications (TET2, IDH1 and IDH2, DNMT3A, ASXL1, WT1, EZH2), DNA repair dysregulation (TP53, NPM1), cell cycle inhibition and deficiency in differentiation (NPM1, CEBPA, TP53 and GATA2) as a consequence of somatic mutations come out as key elements in acute myeloid leukemia and may contribute to relapse and resistance to therapies. …”
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    Landscape of Tumor Suppressor Mutations in Acute Myeloid Leukemia
  16. 1656
    “…Among them, the alterations in the promoter region of the telomerase reverse transcriptase (TERTp) gene are highly recurrent and occur in 70% to 80% of all glioblastomas, including glioblastoma IDH wild type and glioblastoma IDH mutated. This review focuses on recent advances related to physiopathological mechanisms, diagnosis, and clinical implications. …”
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    TERT Promoter Alterations in Glioblastoma: A Systematic Review
  17. 1657
    “…Intradural disc herniation (IDH) is usually diagnosed during surgery when a herniated mass is found to have penetrated the ventral dura. …”
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    Intradural Lumbar Disc Herniation From the Lateral Inner Surface of the Dura Without a Penetration Hole: A Case Report
  18. 1658
    “…TSPO tracer uptake correlated with tumor grade at recurrence (p < 0.05), with no significant differences in IDH-wild-type versus IDH-mutant tumors. Within the subgroup of IDH-mutant glioma (n = 46), patients with low SUV(max) (median split, ≤ 1.60) had a significantly longer PRS (median 41.6 vs. 25.3 months, p = 0.031) and TTF (32.2 vs 8.7 months, p = 0.001). …”
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    TSPO PET signal using [(18)F]GE180 is associated with survival in recurrent gliomas
  19. 1659
    “…Therapeutic considerations include inclusion (in IDH mutant) or exclusion (in H3K27M) of adjuvant Temozolomide post radiotherapy and use of molecular targeted therapy (IDH inhibitors). …”
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    METB-05. NON-INVASIVE DIAGNOSIS OF BRAINSTEM GLIOMAS IN PEDIATRIC, ADOLESCENT, AND YOUNG ADULT PATIENTS THROUGH CEREBROSPINAL FLUID CELL-FREE DNA SEQUENCING
  20. 1660
    “…METHODS: Multi-parametric (1)H/HP-(13)C MRI data were acquired from fifteen patients with progressive/treatment-naïve glioblastoma [prog/TN GBM, IDH-wildtype (n = 11)], progressive astrocytoma, IDH-mutant, grade 4 (G4A(IDH+), n = 2) and GBM manifesting treatment effects (n = 2). …”
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    Multi-parametric hyperpolarized (13)C/(1)H imaging reveals Warburg-related metabolic dysfunction and associated regional heterogeneity in high-grade human gliomas
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