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  1. 1661
    “…The G3 gliomas were divided into three groups for the analysis: with this isocitrate dehydrogenase (IDH)-mutation, IDH mutation and a chromosome arm 1p/19q-codeleted (IDHmut1p/19qdel), IDH mutation, 1p/19q-nondeleted (IDHmut1p/19qnondel), and IDH wildtype (IDHwt). …”
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    Comparison of Genetic Profiles and Prognosis of High-Grade Gliomas Using Quantitative and Qualitative MRI Features: A Focus on G3 Gliomas
  2. 1662
    “…BACKGROUND: Survival in patients with IDH1/2-mutant (mt) anaplastic astrocytomas is highly variable. …”
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    Prognostic significance of genome-wide DNA methylation profiles within the randomized, phase 3, EORTC CATNON trial on non-1p/19q deleted anaplastic glioma
  3. 1663
    “…In this study, we utilize low grade glioma RNA-seq data from the Cancer Genome Atlas (TCGA-LGG) and tandem mass-spectrometry on an in-house cohort of 54 formalin-fixed paraffin-embedded (FFPE) LGG specimens to investigate the transcriptomic and proteomic profiles across the three molecular subtypes of LGG (Type I: IDH mutant – 1p19q co-deleted, Type II: IDH mutant – 1p19q retained, Type III: IDH wildtype). …”
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    Integrated proteomic analysis of low-grade gliomas reveals contributions of 1p-19q co-deletion to oligodendroglioma
  4. 1664
    “…We also detected TET1 and IDH2 were decreased in the tumor tissues and the decrease were positively correlated with the 5-hmC. …”
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    Decrease of 5-hydroxymethylcytosine in hepatitis B virus-related hepatocellular carcinoma: A cross-sectional study
  5. 1665
    “…In FASN-deficient cells, reductive carboxylation is mainly catalyzed by isocitrate dehydrogenase-1 (IDH1), but IDH1-generated cytosolic citrate is not utilized for supplying DNL. …”
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    FASN deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress
  6. 1666
    “…Evaluating multi-institutional clinical, genetic and outcome data from 4023 glioma patients over 14 years, across 12 countries, we employ Bayesian generative stochastic block modelling to reveal a hierarchical network structure of tumour genetics spanning molecularly confirmed glioblastoma, IDH-wildtype; oligodendroglioma, IDH-mutant and 1p/19q codeleted; and astrocytoma, IDH-mutant. …”
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    Brain tumour genetic network signatures of survival
  7. 1667
    “…In the 2021 WHO classification of Tumors of the Central Nervous System, additional molecular characteristics have been included, defining the following adult-type diffuse glioma entities: Astrocytoma IDH-mutant, Oligodendroglioma IDH-mutant and 1p/19q-codeleted, and Glioblastoma IDH-wildtype. …”
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    miRNAs and related genetic biomarkers according to the WHO glioma classification: From diagnosis to future therapeutic targets
  8. 1668
    “…The identification of succinate dehydrogenase (SDH), fumarate hydratase (FH), and isocitrate dehydrogenase (IDH) mutations in human cancers has rekindled the idea that altered cellular metabolism can transform cells. …”
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    Transformation by the R Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation
  9. 1669
    “…At present, GBMs are divided in primary and secondary on the basis of the mutational status of the isocitrate dehydrogenase (IDH) genes. In addition, IDH1 and IDH2 mutations are considered crucial to better define the prognosis. …”
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    Pathological and Molecular Features of Glioblastoma and Its Peritumoral Tissue
  10. 1670
    “…Mammalian mitochondrial NAD-dependent isocitrate dehydrogenase (NAD-IDH) catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the tricarboxylic acid cycle. …”
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    Molecular basis for the function of the αβ heterodimer of human NAD-dependent isocitrate dehydrogenase
  11. 1671
    “…This case report aimed to review the bone marrow features of patients with acute myeloid leukemia (AML) treated with isocitrate dehydrogenase 1/2 (IDH1/2) inhibitors. Five patients with AML treated with an IDH1/2 inhibitor were identified and retrospectively reviewed. …”
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    Bone Marrow Features in Patients With Acute Myeloid Leukemia Treated With Novel Targeted Isocitrate Dehydrogenase 1/2 Inhibitors
  12. 1672
    “…In addition to these common metabolites, 2-hydroxygluterate (2HG) has also been quantified using MRSI following the recent discovery of IDH mutations in gliomas. This has opened up targeted drug development to inhibit the mutant IDH pathway. …”
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    Magnetic resonance spectroscopic imaging in gliomas: clinical diagnosis and radiotherapy planning
  13. 1673
    “…Gliomas with low CASC2 expression exhibited a high level of miR-21, which was highly associated with the higher glioma grade (p = 0.0001), IDH1 wild type gliomas (p < 0.0001), and poor patient survival (p < 0.001). …”
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    The Role of CASC2 and miR-21 Interplay in Glioma Malignancy and Patient Outcome
  14. 1674
    “…However, CDKN2A deletion, in IDH-mutant astrocytomas, is a marker of the highest malignancy grade. …”
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    Prognostic and Predictive Biomarkers in Gliomas
  15. 1675
    “…MhIDH showed optimal activity around pH 8 and appeared to be specific for NADP(+) yet promiscuous regarding divalent cations as cofactors. …”
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    Biochemical Characterization of Recombinant Isocitrate Dehydrogenase and Its Putative Role in the Physiology of an Acidophilic Micrarchaeon
  16. 1676
    “…The most remarkable practical change in the current classification involves grading gliomas according to molecular characterization. IDH mutant (10%) and IDH wild-type tumors (90%) are two different entities that possess unique biological features and various clinical outcomes regarding treatment response and overall survival. …”
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    Upstaging and Downstaging in Gliomas—Clinical Implications for the Fifth Edition of the World Health Organization Classification of Tumors of the Central Nervous System
  17. 1677
    “…Background: Intradialytic hypotension (IDH) is a frequent complication of hemodialysis (HD). …”
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    Changes of Hemodynamic Parameters after Intradialytic Glucose Injection
  18. 1678
    “…AH: aconitase, including ACO1, and ACO2. IDH: isocitrate dehydrogenase, including IDH1, IDH2, and IDH3. …”
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    The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis
  19. 1679
    “…Patients showed decreased network controllability and robustness mainly in the isocitratedehydrogenase (IDH) wildtype group, while additional topological shifts of driver and critical nodes were observed mainly in the prognostically more favourable IDH mutated patients. …”
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    Controllability and Robustness of Functional and Structural Connectomic Networks in Glioma Patients
  20. 1680
    “…Herein, we sought to describe our institutional experience and outcomes after GBM IDH-wt re-irradiation. MATERIALS AND METHODS: GBM patients with confirmed IDH-wt status undergoing re-irradiation were included in this single-center, retrospective analysis. …”
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    Outcomes of Isocitrate Dehydrogenase Wild Type Glioblastoma after Re-irradiation
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