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  1. 1741
    “…CONCLUSIONS: This study identified the IDH1 status as the factor with the most influence on the 5-ALA fluorescence of diffuse gliomas.…”
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    Genetic Factors Affecting Intraoperative 5-aminolevulinic Acid-induced Fluorescence of Diffuse Gliomas
  2. 1742
    “…The analysis of protein and RNA expression levels from the Human Protein Atlas showed that IDH2, which was an essential gene in the melanoma models, but not IDH1 protein, was detected in normal skin cell types and melanoma. …”
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    A systems approach reveals distinct metabolic strategies among the NCI-60 cancer cell lines
  3. 1743
    “…Human NAD-dependent isocitrate dehydrogenase (NAD-IDH) catalyzes the oxidative decarboxylation of isocitrate in the citric acid cycle. …”
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    Insights into the inhibitory mechanisms of NADH on the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase
  4. 1744
    por Iuchi, Toshihiko
    Publicado 2019
    “…Recently, the association between IDH mutations and epilepsy had been reported. IDH is an enzyme which converts isocitrate to alpha-ketoglutarate, but when this enzyme is mutated, 2-hydroxyglutarate (2HG) is produced instead of alpha-ketoglutarate. …”
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    MS2 BRAIN TUMORS AND EPILEPSY
  5. 1745
    “…FDA approval of Ivosidenib and Enasidenib, small molecule inhibitors of isocitrate dehydrogenase enzymes (IDH1 and 2) have opened new avenues of treatment. …”
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    Case report of combination therapy with Azacytidine, Enasidenib and Venetoclax in primary refractory AML
  6. 1746
    “…There was no evidence of staining with antibodies to IDH-1 (R132H), H3 K27M, or BRAF V600E. Five tumors showed no staining with antibody to p53 and two tumors showed less than 5% positivity. …”
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    Molecular Immunohistochemical Profile of Angiocentric Glioma
  7. 1747
    “…IDH-wild type (wt) glioblastoma (GB) accounts for approximately 90% of all GB and has a poor outcome. …”
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    BRAF Signaling Inhibition in Glioblastoma: Which Clinical Perspectives?
  8. 1748
    “…Here, we refined SOAT1-expression in GBM and IDH-mutant astrocytoma, CNS WHO grade 4 (HGA), and assessed the distribution of LD in these tumors. …”
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    SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma?
  9. 1749
    “…Patients who recovered, died or were declared ESKD experienced an average of 9, 10 and 16 intradialytic hypotensive (IDH) episodes, respectively. More frequent IDH episodes were associated with increased risk of ESKD (p = 0.01). …”
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    Association of Intradialytic Hypotension and Ultrafiltration with AKI-D Outcomes in the Outpatient Dialysis Setting
  10. 1750
    “…Grade 4 adult gliomas are IDH-mutant astrocytomas and IDH-wildtype glioblastomas. …”
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    Aggressiveness of Grade 4 Gliomas of Adults
  11. 1751
    “…Results A total of 58 cases fit the set criteria, with eight of them (13.7%) harboring an IDH R132H mutation and were hence reclassified as diffuse astrocytoma IDH-mutant, WHO CNS grade 4. …”
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    Reclassification of Glioblastoma Multiforme According to the 2021 World Health Organization Classification of Central Nervous System Tumors: A Single Institution Report and Practical Significance
  12. 1752
    por Park, Jong-Whi
    Publicado 2023
    “…This review presents an overview of the metabolic alterations in IDH-mutant gliomas and IDH-wildtype glioblastoma (GBM). …”
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    Metabolic Rewiring in Adult-Type Diffuse Gliomas
  13. 1753
    “…Intramural hematoma of duodenum (IDH) is a relatively unusual complication associated with endoscopic treatment of bleeding peptic ulcer. …”
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    Intramural hematoma of duodenum: An unusual complication after endoscopic therapy for a bleeding peptic ulcer
  14. 1754
    “…Non-traumatic intramural duodenal hematoma (IDH) with duodenal obstruction caused by acute pancreatitis is rare. …”
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    Successful Endoscopic Decompression for Intramural Duodenal Hematoma with Gastric Outlet Obstruction Complicating Acute Pancreatitis
  15. 1755
    “…CONCLUSION: The co-occurrence of an IDH1 mutated neoplasm and AVM supports the hypothesis that IDH1 mutations may contribute to aberrant angiogenesis and vascular malformation.…”
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    Arteriovenous malformation within an isocitrate dehydrogenase 1 mutated anaplastic oligodendroglioma
  16. 1756
    “…The T2-FLAIR mismatch sign is regarded as a highly specific imaging feature of IDH-mutant, 1p/19q non-codeleted astrocytomas. The case presented herein demonstrates this sign, however, in a non-IDH mutated diffuse midline glioma with a H3K27M mutation, a World Health Organization Grade IV neoplasm. …”
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    A curious case of T2-FLAIR mismatch in H3K27M mutant glioma
  17. 1757
    “…Multinomial logistic regression investigated the associations of the TyG index with hypertension stages (stage 1, stage 2), phenotypes (isolated systolic hypertension [ISH], isolated diastolic hypertension [IDH], systolic diastolic hypertension [SDH]), their progressions. …”
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    Associations of the Triglyceride and Glucose Index With Hypertension Stages, Phenotypes, and Their Progressions Among Middle-Aged and Older Chinese
  18. 1758
    “…Besides, we also found that the expression levels of RUNX1 and IFNGR2 were significantly reduced, and their correlation was enhanced in the IDH-mutant subtype. Patients with a high expression of RUNX1 and/or IFNGR2 (HH/H) in the IDH-mutant subtype showed poorer prognosis and significantly increased infiltration of M2 macrophages. …”
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    Identification of RUNX1 and IFNGR2 as prognostic-related biomarkers correlated with immune infiltration and subtype differentiation of low-grade glioma
  19. 1759
    “…In 2021, the World Health Organization reclassified glioblastoma, the most common form of adult brain cancer, into isocitrate dehydrogenase (IDH)-wild-type glioblastomas and grade IV IDH mutant (G4 IDHm) astrocytomas. …”
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    Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity
  20. 1760
    por Yin, William J.
    Publicado 2023
    “…A significant proportion of lower-grade glioma as well as many other types of human cancers are associated with neomorphic mutations in IDH1/2 genes (mIDH1/2). These mutations lead to an aberrant accumulation of 2-hydroxyglutarate (2-HG). …”
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    A bacterial enzyme may correct 2-HG accumulation in human cancers
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