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  1. 1801
    “…RESULTS: Of the molecular markers investigated (all genes mutated at a population frequency >1.7 % and frequent chromosomal imbalances) in the entire glioma dataset, 57 were significantly associated with overall survival. Of these, IDH1 or IDH2 mutations are associated with lowest hazard ratio, which confirms IDH as the most important prognostic marker in diffuse gliomas. …”
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    PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patients
  2. 1802
    por Reinhardt, Annekathrin, Stichel, Damian, Schrimpf, Daniel, Koelsche, Christian, Wefers, Annika K., Ebrahimi, Azadeh, Sievers, Philipp, Huang, Kristin, Casalini, M. Belén, Fernández-Klett, Francisco, Suwala, Abigail, Weller, Michael, Gramatzki, Dorothee, Felsberg, Joerg, Reifenberger, Guido, Becker, Albert, Hans, Volkmar H., Prinz, Marco, Staszewski, Ori, Acker, Till, Dohmen, Hildegard, Hartmann, Christian, Paulus, Werner, Heß, Katharina, Brokinkel, Benjamin, Schittenhelm, Jens, Buslei, Rolf, Deckert, Martina, Mawrin, Christian, Hewer, Ekkehard, Pohl, Ute, Jaunmuktane, Zane, Brandner, Sebastian, Unterberg, Andreas, Hänggi, Daniel, Platten, Michael, Pfister, Stefan M., Wick, Wolfgang, Herold-Mende, Christel, Korshunov, Andrey, Reuss, David E., Sahm, Felix, Jones, David T. W., Capper, David, von Deimling, Andreas
    Publicado 2019
    “…In comparison to supratentorial localization, the MC GBM IDH wildtype subclass midline was overrepresented, whereas the MCs GBM IDH wildtype subclass mesenchymal and subclass RTK II were underrepresented in the cerebellum. …”
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    Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities
  3. 1803
    “…It can occur due to sporadic, de novo, mosaic pathogenic variants in the gene encoding isocitrate dehydrogenase 1 (IDH1) or isocitrate dehydrogenase 2 (IDH2). IDH1 variants are associated with endocrine manifestations, such as pituitary adenomas. …”
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    Maffucci Syndrome, Calcium Homeostasis, and Endocrine Challenges in Management
  4. 1804
    “…Methods: Eighty-five patients with primary IDH-wildtype GB treated with the standard therapy between 2012 and 2019 were analyzed retrospectively. …”
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    Online Artículo Texto
    A Simple Preoperative Blood Count to Stratify Prognosis in Isocitrate Dehydrogenase-Wildtype Glioblastoma Patients Treated with Radiotherapy plus Concomitant and Adjuvant Temozolomide
  5. 1805
    “…High 5MC and DNMT1, and low IDH1 levels were associated with poorer outcome when looking at all canine MCT cases. …”
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    Online Artículo Texto
    Prognostic value of epigenetic markers for canine mast cell cancer
  6. 1806
    “…MATERIAL AND METHODS: Patients treated for a 1p/19q-codeleted and IDH-mutant ODG were evaluated. The patient and tumor characteristics were analyzed for their influence on PFS and OS. …”
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    Treating oligodendroglioma – An analysis of a homogeneous 1p/19q-codeleted and isocitrate dehydrogenase-mutant patient cohort
  7. 1807
    “…BACKGROUND: Intradural disc herniations (IDH) are uncommon and can be found in the cervical spine. …”
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    Online Artículo Texto
    Intradural cervical herniated nucleus pulposus presentation and management: a case report
  8. 1808
    “…For subgroup analysis, we analyzed multiple factors including iso-citrate dehydrogenase (IDH) genotype, age, diagnosis, pTERT region, so as to locate the sources of heterogeneity. …”
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    Association of human telomerase reverse transcriptase promoter mutation with unfavorable prognosis in glioma: A systematic review and meta-analysis
  9. 1809
    “…About 40% of BTC bear a targetable molecular alteration, the most frequent being FGFR2 fusions and IDH1 mutations in about 15% of intrahepatic cholangiocarcinomas. …”
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    Targetable Molecular Alterations in the Treatment of Biliary Tract Cancers: An Overview of the Available Treatments
  10. 1810
    “…Molecular genetics study of IDH-mutant is used for WHO grading and management of the oligodendrogliomas lesions. …”
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    Online Artículo Texto
    GLIOMA-11 JUVENILE OLIGODENDROGLIOMA OF THE OPTIC NERVE: UNIQUE CASE REPORT AND CHALLENGE IN DIAGNOSIS ACCORDING TO CURRENT 2021 WHO CLASSIFICATION IN LIMITED RESOURCES COUNTRIES.
  11. 1811
    “…Almost 70% of the cases were both IDH-1 and p53 wild-type, and we observed the presence of both mutations in only 3.7% of the cases. …”
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    General Clinico-Pathological Characteristics in Glioblastomas in Correlation with p53 and Ki67
  12. 1812
    “…Using candidate gene association mapping, we identified that this non-synonymous polymorphism was associated with IDH activity variation. The proposed mechanism for the IDH activity variation includes additional components regulating protein level. …”
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    Genetic Analysis of Central Carbon Metabolism Unveils an Amino Acid Substitution That Alters Maize NAD-Dependent Isocitrate Dehydrogenase Activity
  13. 1813
    “…We identified 26 gliomas having the R132 mutation in Isocitrate DeHydrogenase 1 (mIDH1). A double immunofluorescence approach identifying mIDH1 positive tumor cells and a panel of markers was used. …”
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    Glioma Cells in the Tumor Periphery Have a Stem Cell Phenotype
  14. 1814
    “…BRAF V600E mutations were detected in 50% of the PXA but not in any of the gcGBM (50% vs. 0%, p-value < 0.001). IDH1 R132 and IDH R172 mutations were not present in any of the PXA and gcGBM cases. …”
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    Online Artículo Texto
    MGMT Promoter Methylation and BRAF V600E Mutations Are Helpful Markers to Discriminate Pleomorphic Xanthoastrocytoma from Giant Cell Glioblastoma
  15. 1815
    “…TET2 and DNMT3A mutations were identified in both the PD1+ cells and the CD20+ cells in 15/16 and 4/7 cases, respectively. All the RHOA and IDH2 mutations were confined to the PD1+ cells, indicating that some, including RHOA and IDH2 mutations, being specific events in tumor cells. …”
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    Identification of cell-type-specific mutations in nodal T-cell lymphomas
  16. 1816
    “…METHODS: We retrospectively reviewed 143 cases with both molecular information (IDH1/TERT/1p19q) and MRI images diagnosed as cerebral diffuse gliomas. …”
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    Anatomic mapping of molecular subtypes in diffuse glioma
  17. 1817
    “…However, total number of mutations/patient was negatively associated with overall drug response (odds ratio [OR]: 0.56, 95% confidence interval [CI]: 0.33–0.94; p=0.028), and a positive association was found for having ≥1 mutation in a DNA methylation-related gene: TET2, DNMT3A, IDH1 and/or IDH2 (OR: 4.76, 95%CI: 1.31–17.27; p=0.017). …”
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    Online Artículo Texto
    Mutations in the DNA methylation pathway and number of driver mutations predict response to azacitidine in myelodysplastic syndromes
  18. 1818
    “…There was no difference in PsP rate based on radiation type, radiation dose, tumor grade, 1p19q codeletion, or IDH status. PsP occurred earlier in oligodendroglioma patients treated with protons compared to photons, 48 days vs. 131 days, p < .01. …”
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    Analysis of pseudoprogression after proton or photon therapy of 99 patients with low grade and anaplastic glioma()
  19. 1819
    “…PLCG1 was mutated in 14.3%, IDH2 in 11.2% and DNMT3A in 7.1% of cases, respectively. …”
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    Overlap at the molecular and immunohistochemical levels between angioimmunoblastic T-cell lymphoma and a subgroup of peripheral T-cell lymphomas without specific morphological features
  20. 1820
    “…In 36 patients with isocitrate dehydrogenases 1 and 2 (IDH1/2) data, only one had IDH1 mutation and no patient had IDH2 mutation. …”
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    Pleomorphic xanthoastrocytomas of adults: MRI features, molecular markers, and clinical outcomes
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