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  1. 1821
    por Wu, Shuang, Meng, Jin, Yu, Qi, Li, Ping, Fu, Shen
    Publicado 2019
    “…Our aim was to identify the optimal radiomics-based machine learning method for isocitrate dehydrogenase (IDH) genotype prediction in diffuse gliomas. METHODS: Eight classical machine learning methods were evaluated in terms of their stability and performance for pre-operative IDH genotype prediction. …”
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    Radiomics-based machine learning methods for isocitrate dehydrogenase genotype prediction of diffuse gliomas
  2. 1822
    “…Although all biopsies were classified as GBM IDH wt/mutated by methylation analysis, the assigned subclass differed in samples from the same patient. …”
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    Intratumor DNA methylation heterogeneity in glioblastoma: implications for DNA methylation-based classification
  3. 1823
    “…This finding could aid, together with IDH1, in the identification of glioblastomas with better prognosis.…”
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    Anti-Apoptotic and Anti-Oxidant Proteins in Glioblastomas: Immunohistochemical Expression of Beclin and DJ-1 and Its Correlation with Prognosis
  4. 1824
    “…MATH values were increased in patients with glioma with the wild-type isocitrate dehydrogenase (NADP((+))) (IDH)1/2 (IDH-wt) gene (P=0.001) and glioblastoma (GBM; P=0.001). …”
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    Mutant-allele tumor heterogeneity in malignant glioma effectively predicts neoplastic recurrence
  5. 1825
    “…TERT was the most frequently mutated gene (74.3%). IDH1/2 mut were mutually exclusive with mut in the neurofibromin 1 (NF1) gene. …”
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    Is There an Independent Role of TERT and NF1 in High Grade Gliomas?
  6. 1826
    “…Similar observations are made for central cartilaginous tumours, which frequently harbour specific point mutations in the metabolic enzymes IDH1 or IDH2. Besides an altered methylation pattern on histones, IDH mutations also induce a global DNA hypermethylation phenotype. …”
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    Mutation-driven epigenetic alterations as a defining hallmark of central cartilaginous tumours, giant cell tumour of bone and chondroblastoma
  7. 1827
    “…RESULTS: We could see that the high APT signals seemed to be related to IDH wild status and high glioma grading (IDH status; p=0.171, Grade; p=0.113). …”
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    NI-10 AVAILABILITY OF AMIDE PROTON TRANSFER-WEIGHTED MRI METRICS IN GLIOMA
  8. 1828
    “…Despite the prognostic value of IDH and other gene mutations found in diffuse glioma, markers that judge individual prognosis of patients with diffuse lower‐grade glioma (LGG) are still lacking. …”
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    A five‐microRNA signature for individualized prognosis evaluation and radiotherapy guidance in patients with diffuse lower‐grade glioma
  9. 1829
    “…Reverse transcription and quantitative PCR and enzyme activity assays showed that this engineered CRISPRi system significantly repressed the genes encoding IDH and PK, resulting in simultaneous reduction in the activities of IDH and PK. …”
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    CRISPR interference-guided modulation of glucose pathways to boost aconitic acid production in Escherichia coli
  10. 1830
    “…In addition, we also found that aggressive adjuvant therapy can significantly improve clinical outcomes of IDH1-mutated patients but no significant prognostic value for IDH1-wildtyped patients. …”
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    Long-term efficacy of surgical resection with or without adjuvant therapy for treatment of secondary glioblastoma in adults
  11. 1831
    “…Preclinical data suggest synergy between venetoclax and FLT3- and IDH-targeted therapies, and doublets of venetoclax with inhibitors targeting these mutations have shown promising clinical activity in early stage trials. …”
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    New directions for emerging therapies in acute myeloid leukemia: the next chapter
  12. 1832
    “…We could not examine FMISO PET for one diffuse astrocytoma with IDH1 mutation. The T/N ratios of FDG, MET, and FLT and the T/B ratio of FMISO were 1.07, 2.76, 4.6, and 1.12 for pilocytic astrocytoma; 0.65, 4.6, 7.67, and 1.38 for pleomorphic xanthoastrocytoma; 0.61, 2.14, and 3.82 for diffuse astrocytoma with IDH1 mutation; and 0.79, 1.78, 5, and 1.49 for ganglioglioma, respectively. …”
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    IMG-02. USEFUL DIAGNOSIS OF PEDIATRIC CYSTIC BRAIN TUMORS USING MULTIPLE POSITRON EMISSION TOMOGRAPHY STUDIES
  13. 1833
    “…A subset of these tumors harbour mutations in the enzyme isocitrate dehydrogenase (IDH) which produces the novel oncometabolite 2-hydroxyglutarate (2HG). …”
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    IMG-21. PROSPECTIVE PREOPERATIVE DETERMINATION OF ISOCITRATE DEHYDROGENASE MUTATION IN GLIOMAS USING SPECTRAL EDITING MAGNETIC RESONANCE SPECTROSCOPY
  14. 1834
    “…In half of the patients from the group DMGs IDH wild type, examined by methylation array, PDGFRA amplification was found. …”
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    HGG-31. UNIQUE BIOLOGICAL CHARACTERISTICS OF RADIATION-INDUCED GLIOMAS
  15. 1835
    “…BACKGROUND: Combined whole-exome sequencing (WES) and somatic copy number alteration (SCNA) information can separate isocitrate dehydrogenase (IDH)1/2-wildtype glioblastoma into two prognostic molecular subtypes, which cannot be distinguished by epigenetic or clinical features. …”
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    Radiogenomic modeling predicts survival-associated prognostic groups in glioblastoma
  16. 1836
    “…With a visualization approach, Sankey diagrams show the relationship of the histological type, IDH status, and predict index. In TCGA and CGGA cohorts, both low‐risk groups displayed better survival rate in LGG while histological type and IDH status did not show consistency results. …”
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    An autophagic gene‐based signature to predict the survival of patients with low‐grade gliomas
  17. 1837
    “…Glioblastoma (44%) accounted for the largest proportion of BSGs, and oligodendroglioma (2 of 50) was rarely encountered. The IDH mutation (6 of 44) occurred infrequently in astrocytomas, and IDH-mutant tumors harbored both ATRX loss and MGMT promoter methylation at a relatively low level. …”
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    Clinical and Genetic Features of Brainstem Glioma in Adults: A Report of 50 Cases in a Single Center
  18. 1838
    por Thol, Felicitas, Heuser, Michael
    Publicado 2021
    “…Ivosidenib and enasidenib, inhibitors for mutated isocitrate dehydrogenase (IDH) 1 and 2, respectively, have received approval for IDH1/IDH2 mutated r/r AML by the FDA (not EMA). …”
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    Treatment for Relapsed/Refractory Acute Myeloid Leukemia
  19. 1839
    “…Here, we examined the relationship of circadian clock genes, IDH mutational status, and prognosis in glioma patients by using unsupervised clustering of the expression of 13 clock genes. …”
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    Association of Circadian Clock Gene Expression with Glioma Tumor Microenvironment and Patient Survival
  20. 1840
    “…Isocitrate dehydrogenases 1 (IDH1) mutations, including R132C, V178I, and S278L, were identified in 38% of cases and co-existed with BRAF/HRAS mutations. …”
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    NGS-Based Analysis of Atypical Deep Penetrating Nevi
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