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  1. 1
    “…In this review, the contribution of IDH1/IDH2 mutations in leukemogenesis and progress of targeted therapeutics in AML will be highlighted.…”
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    IDH1/IDH2 Inhibition in Acute Myeloid Leukemia
  2. 2
    “…IDH1 functions in the cytosol and peroxisomes, whereas IDH2 and IDH3 are both localized in the mitochondria. …”
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    Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH Mutations in Glioblastoma
  3. 3
    “…We tested 87 gliomas for IDH1 and IDH2 mutations using the peptide nucleic acid clamp method. …”
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    Estimation of the occurrence rates of IDH1 and IDH2 mutations in gliomas and the reconsideration of IDH-wildtype anaplastic astrocytomas: an institutional experience
  4. 4
    “…IDH mutations are typically characterized by mutually exclusive amino acid substitutions in the genes encoding for the IDH1 and the IDH2 enzyme isoforms. …”
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    Concurrent IDH1 and IDH2 mutations in glioblastoma: A case report
  5. 5
    “…However, whether mutant IDH1 protein is required for maintaining IDH1 mutated tumor cell growth remains unknown. …”
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    Mutant IDH1 is required for IDH1 mutated tumor cell growth
  6. 6
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    IDH1 and IDH2 mutations in myelodysplastic syndromes and role in disease progression
  7. 7
    “…Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to α-ketoglutarate. …”
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    IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives
  8. 8
    “…BACKGROUND: Selective IDH1 and IDH2 inhibitors have been approved for targeted therapy of acute myeloid leukemia. …”
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    IDH1 and IDH2 mutations in lung adenocarcinomas: Evidences of subclonal evolution
  9. 9
    “…Isocitrate dehydrogenase (IDH) mutant and wildtype glioblastoma multiforme (GBM) often show overlapping features on magnetic resonance imaging (MRI), representing a diagnostic challenge. …”
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    Deep Learning Can Differentiate IDH-Mutant from IDH-Wild GBM
  10. 10
    “…IDH1 and IDH2 mutations (IDH1/2(Mut)) are recognized as recurrent genetic alterations in acute myeloid leukemia (AML) and associated with both clinical impact and therapeutic opportunity due to the recent development of specific IDH1/2(Mut) inhibitors. …”
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    Oncogenetic landscape and clinical impact of IDH1 and IDH2 mutations in T-ALL
  11. 11
    “…BACKGROUND: Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are frequent in low-grade gliomas and secondary glioblastomas (sGBM). …”
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    The comparison of clinical and biological characteristics between IDH1 and IDH2 mutations in gliomas
  12. 12
    “…CONCLUSION: Our data illustrate the potential utility of NAMPT inhibition to kill a subset of IDH-WT and IDH mutant lines, but conflict with previously reported TMZ synergy and correlation with mutant IDH. …”
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    DDRE-12. HETEROGENOUS RESPONSE OF IDH-MUTANT AND IDH-WT GLIOMA TO NAMPT INHIBITION
  13. 13
    “…Acute myeloid leukemia is a genetically heterogeneous hematologic malignancy; approximately 20% of AML harbors a mutation in the isocitrate dehydrogenase (IDH) genes, IDH1 or IDH2. These recurrent mutations in key metabolic enzymes lead to the production of the oncometabolite 2-hydroxyglutarate, which promotes leukemogenesis through a block in normal myeloid differentiation. …”
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    Acute myeloid leukemia with IDH1 and IDH2 mutations: 2021 treatment algorithm
  14. 14
    “…PURPOSE OF REVIEW: Isocitrate dehydrogenase (IDH) mutant gliomas are a distinct type of primary brain tumors with unique characteristics, behavior, and disease outcomes. …”
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    Therapies for IDH-Mutant Gliomas
  15. 15
    “…In this review article, updates on the current and novel therapies in IDH-wildtype GBM will be discussed. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13311-022-01251-6.…”
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    Updates in IDH-Wildtype Glioblastoma
  16. 16
    “…Gliomas with mutations in isocitrate dehydrogenase 1 or 2 (IDHmut) are more likely than IDH–wild type (IDHwt) gliomas to cause seizures as part of their initial clinical presentation. …”
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    Postoperative risk of IDH-mutant glioma–associated seizures and their potential management with IDH-mutant inhibitors
  17. 17
    “…Mutations in genes encoding isocitrate dehydrogenase isoforms 1 (IDH1) and 2 (IDH2) have been associated with good prognosis for patients with brain neoplasias and have been commonly found together with mutated TP53 gene. …”
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    IDH1/IDH2 but Not TP53 Mutations Predict Prognosis in Bulgarian Glioblastoma Patients
  18. 18
    “…Isoform-selective IDH inhibitors which suppress 2-HG production and induce antitumor responses in cells with IDH1 and IDH2 mutations were developed and validated in preclinical settings. …”
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    Consequences of IDH1/2 Mutations in Gliomas and an Assessment of Inhibitors Targeting Mutated IDH Proteins
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    “…We hypothesized that the patterns of DNA methylation, and transcriptome profiles, would vary among IDH(mut) cancers, especially gliomas. Using Illumina 450K and RNA-Seq data from The Cancer Genome Atlas, we show that of 365,092 analyzed CpG sites, 70,591 (19%) were hypermethylated in IDH(mut) gliomas compared to wild-type (IDH(wt)) gliomas, and only 3%, 2%, and 4% of CpG sites were hypermethylated in IDH(mut) AML, melanoma, and cholangiocarcinoma, relative to each of their IDH(wt) counterparts. …”
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    Methylation and transcription patterns are distinct in IDH mutant gliomas compared to other IDH mutant cancers
  20. 20
    “…In this study, the expressions of IDH1 and podoplanin (Pdpn) were determined in IDH-mutated and IDH-wild-type gliomas, and their relationships in glioma were further analyzed. …”
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    Wild-Type IDH1 and Mutant IDH1 Opposingly Regulate Podoplanin Expression in Glioma()()
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