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201por Schleinitz, Nicolas, Chiche, Laurent, Guia, Sophie, Bouvier, Gaëlle, Vernier, Julie, Morice, Alexis, Houssaint, Elisabeth, Harlé, Jean Robert, Kaplanski, Gilles, Montero-Julian, Félix A., Vély, Frédéric“…DAP12 is an ITAM-bearing transmembrane adaptor originally identified on the surface of Natural Killer cells. …”
Publicado 2009
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202“…For example, immunoreceptor tyrosine-based activation motifs (ITAM) of the envelope transmembrane protein (TM) are essential determinants of infection. …”
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203por Sakemura, Reona, Hayakawa, Hiroshi, Iida, Hiroatsu, Ito, Masafumi, Kajiguchi, Tomohiro“…Diarrhea after hematopoietic stem cell transplantation (HSCT) can be life-threatening, and its etiology includes conditioning regimens, graft-versus-host disease (GVHD), infections, and transplantation-associated microangiopathy (iTAM). Cord colitis syndrome (CCS) has been described as a syndrome of culture-negative and antibiotic-responsive persistent watery and non-bloody diarrhea of uncertain pathogenesis and occurs in umbilical cord blood transplantation (UCBT) recipients. …”
Publicado 2017
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204por Kpetemey, Marilyne, Dasgupta, Subhamoy, Rajendiran, Smrithi, Das, Susobhan, Gibbs, Lee D., Shetty, Praveenkumar, Gryczynski, Zygmunt, Vishwanatha, Jamboor K.“…We found that ITAM-phosphorylation of MIEN1 is significantly impaired in isoprenylation-deficient MIEN1 mutants indicating that prenylation of MIEN1 and membrane association is required for cross-phosphorylation of tyrosine residues. …”
Publicado 2015
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206Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injurypor Logan, Mary A., Hackett, Rachel, Doherty, Johnna, Sheehan, Amy, Speese, Sean D., Freeman, Marc R.“…Draper-I promotes engulfment of axonal debris through an immunoreceptor tyrosine-based activation motif (ITAM). In contrast, Draper-II, an alternative splice variant, potently inhibits glial engulfment function. …”
Publicado 2012
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207“…Furthermore, immunoprecipitation results indicated that OCILRP2 could interact with the DAP12 protein, an adaptor containing an intracellular ITAM motif that can transduce signals to induce MAP kinase activation for T cell activation. …”
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208“…In this study, an ancient BCR-like molecule (designated as CgIgR) with an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic tail was identified from the Pacific oyster Crassostrea gigas to investigate its involvement in immune response. …”
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209“…The geometrical feature parameters of 15 different aggregates were examined by AGCES and the corresponding surface properties of asphalt pavement prepared from the mentioned aggregates were evaluated by sand patch method, 2-Dimension Image-based Texture Analysis Method (2D-ITAM) and Walking Friction Tester (WFT), respectively. …”
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210por Bärring, O, Bonfillou, Eric, Clement, B, Coelho Dos Santos, Miguel, Dore, Vincent, Gentit, Alain, Grossir, Anthony, Salter, Wayne, Valsan, Liviu, Xafi, Afroditi“…We will also describe tools and procedures developed for automating tle registration, burn-in testing, acceptance and maintenance of tle equipment as well as an independent but important clange to tle IT assets management (ITAM) developed in parallel as part of tlie CERN IT Agile Infrastructure project. …”
Publicado 2014
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211por Despars, Geneviève, Pandruvada, Subramanya N. M., Anginot, Adrienne, Domenget, Chantal, Jurdic, Pierre, Mazzorana, Marlène“…ITAM-bearing transmembrane signaling adaptors such as DAP12 and FcRγ are important players in bone homeostasis, but their precise role and functions are still unknown. …”
Publicado 2013
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212por Bridgeman, J S, Ladell, K, Sheard, V E, Miners, K, Hawkins, R E, Price, D A, Gilham, D E“…In this study, we used a series of immunoreceptor tyrosine-based activation motif (ITAM)-mutant and transmembrane-modified receptors to demonstrate that CARs activate T cells both directly via the antigen-ligated signalling chain and indirectly via associated chains within the TCR complex. …”
Publicado 2014
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213“…GP1b was shown to signal via the FcRγ-ITAM (Fc Receptor γ-Immunoreceptor tyrosine-based activation motif) pathway, activating spleen tyrosine kinase (Syk) and other tyrosine kinases. …”
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214por Sahillioglu, Ali Can, Toebes, Mireille, Apriamashvili, Georgi, Gomez, Raquel, Schumacher, Ton N.“…The modular nature of the Chemically Regulated - SH2-delivered Inhibitory Tail (CRASH-IT) switch concept, in which inhibitory domains are brought to activating immune receptors in a controlled manner, makes it a versatile platform to regulate the activity of cell products that signal through immunoreceptor tyrosine-based activation motif (ITAM)–containing receptors.…”
Publicado 2021
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215“…Here, we characterized the function of the guinea pig homologue of Mincle (gpMincle) and MCL (gpMCL). gpMincle directly bound to TDM and transduced an activating signal through ITAM-bearing adaptor molecule, FcRγ. Whereas, gpMCL lacked C-terminus and failed to bind to TDM. mRNA expression of gpMincle was detected in the spleen, lymph nodes and peritoneal macrophages and it was strongly up-regulated upon stimulation of zymosan and TDM. …”
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216por Qiao, Jianlin, Arthur, Jane F., Gardiner, Elizabeth E., Andrews, Robert K., Zeng, Lingyu, Xu, Kailin“…GPVI forms a functional complex with the Fc receptor γ-chain (FcRγ) that, following receptor dimerization, signals via an intracellular immunoreceptor tyrosine-based activation motif (ITAM), leading to rapid activation of Src family kinase signaling pathways. …”
Publicado 2017
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217“…Myeloid C‐type lectin receptors (CLRs), which consist of an extracellular carbohydrate recognition domain and intracellular signal transducing motif such as the immunoreceptor tyrosine‐based activation motif (ITAM) or immunoreceptor tyrosine‐based inhibitory motif (ITIM), are innate immune receptors primarily expressed on myeloid lineage cells such as dendritic cells (DCs) and Mϕs. …”
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218“…Platelet activation via immunoreceptor tyrosine-based activation motif (ITAM) coupled, G Protein-Coupled Receptors (GPCR) and thromboxane receptor (TP)-mediated signaling pathways led to increased PANX1 phosphorylation at Tyr(198) and Tyr(308). …”
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219por Reis, José Lourenço, Rosa, Natacha Nurdine, Ângelo-Dias, Miguel, Martins, Catarina, Borrego, Luís Miguel, Lima, Jorge“…The immune shift from NK surveillance to NK suppression is also apparent in the greater relative number of ITIM domains compared with ITAM domains in NKRs. In conclusion, NK receptor activity seems to dictate the immunocompetency of women to clear endometriotic cells from the peritoneal cavity. …”
Publicado 2022
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