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3761por Sampson, Maureen, Ballout, Rami A., Soffer, Daniel, Wolska, Anna, Wilson, Sierra, Meeusen, Jeff, Donato, Leslie J., Fatica, Erica, Otvos, James D., Brinton, Eliot A., Rosenson, Robert S., Wilson, Peter, Amar, Marcelo, Shamburek, Robert, Karathanasis, Sotirios K., Remaley, Alan T.“…Furthermore, based on the Atherosclerosis Risk in Communities (ARIC) cohort (N = 14,742), the lipoprotein phenotypes differ in their association with ASCVD (TypeV>IIb > IVb > IIa > IVa > normolipidemic) and can be used prognostically as risk enhancer conditions in the management of patients. …”
Publicado 2021
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3762por Guo, SuPing, Liu, FangJie, Liu, Hui, Wu, YingJia, Zhang, XuHui, Ye, WenFeng, Luo, GuangYu, Li, QiWen, Chen, NaiBin, Hu, Nan, Wang, Bin, Zhang, Jun, Lin, MaoSheng, Feng, HuiXia, Qiu, Bo“…METHODS: This single-arm, phase II study enrolled pathologically confirmed, stage II–IVa ESCC of 70–80 years old and Eastern Cooperative Oncology Group performance status (ECOG PS) 0–2. …”
Publicado 2021
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3763por Srijuntongsiri, Gun, Mhoowai, Atiwat, Samngamnim, Sukuma, Assavacheep, Pornchalit, Bossé, Janine T., Langford, Paul R., Posayapisit, Navaporn, Leartsakulpanich, Ubolsree, Songsungthong, Warangkhana“…Five marker candidates are within the apxIVA gene, a known A. pleuropneumoniae-specific gene, validating our in silico marker discovery method. …”
Publicado 2022
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3764por Nawashiro, Ayako, Tanaka, Fumihiro, Taira, Akihiro, Shinohara, Shinji, Takenaka, Masaru, Kuroda, Koji, Shimajiri, Shohei“…Ten months prior to this administration, he had been diagnosed with unresectable large cell carcinoma with malignant pericardial effusion (clinical stage IVA/T3N2M1A; no driver-gene alteration) originating from the right upper lobe (RUL). …”
Publicado 2022
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3765por Fujii, Hideki, Otani, Takuya, Kawaguchi, Yasuhiko, Hayama, Tetsuo, Abe, Toshiomi, Takahashi, Motoi, Saito, Mitsuru“…LEVEL OF EVIDENCE: Therapeutic study, Level IVa.…”
Publicado 2020
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3766por Taha, Ali, ElZaher, ElZaher Hassan, ElGanzoury, Ibrahim, Ashoub, Mostafa, Khairy, Amr“…Using the proper fixation and implant can achieve a reliable fixation and good functional recovery. LEVEL OF EVIDENCE: IVa…”
Publicado 2021
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3767“…Diagnosis of choledochal cyst type isovaleric acidaemia (IVA) was made. Explorative laparotomy was done, huge cystic mass occupying common bile duct was seen below the liver with distended gallbladder covered with visceral peritoneum. …”
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3768por Liu, Bing, Sun, Zhen, Xu, Zi-Liang, Zhao, Hong-Liang, Wen, Di-Di, Li, Yong-Ai, Zhang, Fan, Hou, Bing-Xin, Huan, Yi, Wei, Li-Chun, Zheng, Min-Wen“…METHODS: This multicenter retrospective study recruited 263 patients with International Federation of Gynecology and Obetrics (FIGO) stage IB-IVA treated with CCRT for whom pretreatment MRI scans were performed. …”
Publicado 2022
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3769por Vijayvargiya, Pooja, Trivedi, Sumita, Rupji, Manali, Song, Haocan, Liu, Yuan, Jiang, Renjian, Kaka, Azeem S, Chen, Georgia Z, Stokes, William, Steuer, Conor, Shin, Dong M, Beitler, Jonathan J, Patel, Mihir R, Aiken, Ashley, Saba, Nabil F“…Comparing the eighth versus seventh edition for our HPV-selected cohort, clinical staging changed for 92.3% of patients and 10-year OS was 62.2%, 61.2%, 35.3%, and 15.5% for Stage I, II, III, and IV, versus 52.9%, 59.2%, 61.6%, 55.1%, 38.3%, and 15.5% for stage I, II, III, IVA, IVB, and IVC, respectively. A similar pattern was observed for 10-year DSS. …”
Publicado 2022
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3770por Tovanabutra, Chokaew, Asakij, Tussawan, Rongsriyam, Kanisa, Tangjitgamol, Siriwan, Tharavichitkul, Ekkasit, Sukhaboon, Jirasak, Kridakara, Lieutenant Col. Apiradee, Paengchit, Kannika, Khunnarong, Jakkapan, Atjimakul, Thiti, Pariyawateekul, Piyawan, Tanprasert, Prapai, Tungkasamit, Tharathorn, Lorvidhaya, Vichan“…METHODS: Patients aged 18–70 years who had FIGO stage IIB-IVA without para-aortic lymph node enlargement (excluding by International Federation of Gynecology and Obstetrics (FIGO) 2018 stage IIIC2r), The Eastern Cooperative Oncology Group (ECOG) scores 0–2, and non-aggressive histopathology were randomized to have CCRT with weekly cisplatin followed by observation (arm A) or ACT with paclitaxel plus carboplatin every 4 weeks for 3 cycles (arm B). …”
Publicado 2021
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3771por Liu, Zhou, Zou, Liyan, Yang, Qian, Qian, Long, Li, Tianran, Luo, Honghong, Che, Canwen, Lei, Yuanyuan, Chen, Peng, Qiu, Chunyan, Liu, Xin, Wu, Yin, Luo, Dehong“…APT signals showed no significant difference between undifferentiated and differentiated NPC subtypes groups, different EBV-DNA groups, or among T, N, M stages and overall clinical stages of II, III, IVA and IVB (all P >0.05). Similarly, baseline APT-related parameters did not differ significantly among different treatment response groups after IC, no matter if evaluated with RECIST criteria or sum volumetric regression ratio (SVRR) (all P >0.05). …”
Publicado 2022
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3772“…In on-pump, there were more grade I and grade II complications, particularly grade I and II transfusions (P < 0.001) and grade I acute kidney injury (P = 0.039), and more grade IVa respiratory failures (P = 0.047). Patients with ≥IIIa complications had greater cumulative 1-year mortality (P < 0.001). …”
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3773por Shen, Yi-Luen, Shen, Chia-I, Chiang, Chi-Lu, Huang, Hsu-Ching, Chou, Kun-Ta, Chiu, Chao-Hua, Chen, Yuh-Min, Luo, Yung-Hung“…The other independent prognostic factors of OS include stage IVA disease (adjusted HR = 0.57, P = 0.037), initial liver metastasis (adjusted HR = 2.00, P = 0.049), ICI monotherapy (adjusted HR = 1.73, P = 0.042) and ICI related pneumonitis (adjusted HR = 3 .44, P = 0.025). …”
Publicado 2022
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3774por Nair, Vivek, Auger, Samuel, Kochanny, Sara, Howard, Frederick M., Ginat, Daniel, Pasternak-Wise, Olga, Juloori, Aditya, Koshy, Matthew, Izumchenko, Evgeny, Agrawal, Nishant, Rosenberg, Ari, Vokes, Everett E., Skandari, M. Reza, Pearson, Alexander T.“…RESULTS: Training data consisted of 2159 total patients (1708 men [79.1%]; median age, 59.6 years [range, 40-90 years]; 401 with stage III disease, 1415 with stage IVA disease, and 343 with stage IVB disease). Cohorts predominantly had HPV-negative disease (1606 [74.4%]). …”
Publicado 2022
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3775por Liu, Yun, Beeraka, Narasimha M, Liu, Junqi, Chen, Kuo, Song, Bo, Song, Zhang, Luo, Jianchao, Liu, Yang, Zheng, Anping, Cui, Yanhui, Wang, Yang, Jia, Zhenhe, Song, Xiangyu, Wang, Xiaohong, Wang, Hongqi, Qi, Xuefeng, Ren, Jinshan, Wu, Liping, Cai, Jixing, Fang, Xainying, Wang, Xin, Sinelnikov, Mikhail Y, Nikolenko, Vladimir N, Greeshma, M V, Fan, Ruitai“…However, no consensus has been established regarding the role of radiotherapy in targeting the primary tumour in patients with stage IVa OSCC. Thus, the aim of this study is to assess the effectiveness of primary radiotherapy combined with S-1 and nedaplatin (NPD) chemotherapy in the patients with stage IV OSCC. …”
Publicado 2022
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3776por Kroese, Tiuri E., Ruurda, Jelle P., Bakker, Anne S., Jairam, Jasvir, Mook, Stella, van der Horst, Sylvia, Meijer, Gert J., Haj Mohammad, Nadia, van Rossum, Peter S.N., van Hillegersberg, Richard“…The incidence of true-positive versus false-positive interval distant metastases for patients with clinical stage II disease was 5% versus 0%; clinical stage III, 14% versus 8%; and clinical stage IVa, 22% versus 9%. CONCLUSIONS: The existing prediction model cannot reliably identify patients at risk for developing interval distant metastases after nCRT for esophageal cancer. …”
Publicado 2022
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3777por Xu, Zhiyuan, Yang, Li, Ng, Wai-Tong, Helali, Aya El, Lee, Victor Ho-Fun, Ma, Lingyu, Liu, Qin, Li, Jishi, Shen, Lin, Huang, Jijie, Zha, Jiandong, Zhou, Cheng, Lee, Anne W. M., Chen, Longhua“…METHODS: Newly diagnosed nasopharyngeal carcinoma (NPC) with stage III-IVA were prospectively recruited from January 2015 to September 2019. …”
Publicado 2022
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3778por Gao, Song, Wang, Shuaibin, Zhao, Zhiying, Zhang, Chao, Liu, Zhicao, Ye, Ping, Xu, Zhifang, Yi, Baozhu, Jiao, Kai, Naik, Gurudatta A., Wei, Shi, Rais-Bahrami, Soroush, Bae, Sejong, Yang, Wei-Hsiung, Sonpavde, Guru, Liu, Runhua, Wang, Lizhong“…Human tubulin beta class IVa (TUBB4A) is a member of the β-tubulin family. …”
Publicado 2022
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3779por Chaudhari, Prashant J., Bari, Sanjaykumar B., Surana, Sanjay J., Shirkhedkar, Atul A., Bonde, Chandrakant G., Khadse, Saurabh C., Ugale, Vinod G., Nagar, Akhil A., Cheke, Rameshwar S.“…On the basis of the pharmacokinetic significance of the aryl thioether linkage in small molecules, 1,3,4-thiadiazole hybrids (IIIa–m) were extended to a new series of 3-((5-(phenylthio)-1,3,4-thiadiazol-2-yl)imino)indolin-2-ones (IVa–m) via thioetherification using bis(triphenylphosphine)palladium(II)dichloride as the catalyst for C–S bond formation. …”
Publicado 2022
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3780por Harris, Alexandria, Branstetter, Barton, Li, Jinhong, Piva, Sara R., Johnson, Jonas T., Nilsen, Marci Lee“…Most survivors had advanced stage III-IVa cancer (94.0%) with treatment modalities including surgery (n=26, 52.0%), chemotherapy (n = 45, 90.0%), and radiation therapy (n = 49, 98.0%). …”
Publicado 2022
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