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  1. 88741
    “…Predictions for patients starting palliative chemotherapy (46.6% of regimens; 95% CI, 45.8%-47.3%), for whom prognosis is particularly important, remained highly accurate (AUC, 0.924; 95% CI, 0.910-0.939). To illustrate model discrimination, patients were ranked initiating palliative chemotherapy by model-predicted mortality risk, and observed mortality was calculated by risk decile. …”
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    Development and Application of a Machine Learning Approach to Assess Short-term Mortality Risk Among Patients With Cancer Starting Chemotherapy
  2. 88742
    “…Therefore, the study not just illustrates the value of non-targeted metabolomics approaches with respect to the huge diversity and numbers of significantly changed metabolites detected (and which would be missed by conventional targeted analyses), but also shows the validity of the non-targeted approach with respect to its precision compared to targeted analyses. …”
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    Application of HPLC–PDA–MS metabolite profiling to investigate the effect of growth temperature and day length on blackcurrant fruit
  3. 88743
    “…CONCLUSIONS: Interventions, even evidence-based, have little impact if not actively used. This study illustrates how user-centered design and service design can be applied to identify and incorporate essential stakeholder aspects in the entire design and development process. …”
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    A Stress Management App Intervention for Cancer Survivors: Design, Development, and Usability Testing
  4. 88744
    “…The survey contained twelve vignettes illustrating advice from veterinary professionals on common behaviour scenarios. …”
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    Exploring the understanding of best practice approaches to common dog behaviour problems by veterinary professionals in Ireland
  5. 88745
    “…This increased eHealth readiness did not cause a larger digital divide. The study illustrates the complexity of conducting a randomized controlled trial to assess the impact of interventions at regional, practice, and household levels. …”
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    The Impact of Superfast Broadband, Tailored Booklets for Households, and Discussions With General Practitioners on Personal Electronic Health Readiness: Cluster Factorial Quasi-Randomized Control Trial
  6. 88746
    “…CONCLUSIONS: The map produced illustrates the potential role of touristically relevant social network data to support global epidemiological surveillance. …”
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    Wet Markets and Food Safety: TripAdvisor for Improved Global Digital Surveillance
  7. 88747
    “…Furthermore, the novel radiopharmaceutical was comparable or better than [(68)Ga]Ga-DOTA-TOC in all preclinical tests, achieving a higher tumour-to-liver contrast in a NET-patient. The results illustrate the potential of the DATA-chelator to facilitate the access to and preparation of (68)Ga-radiotracers in a routine clinical radiopharmacy setting. …”
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    Instant kit preparation of (68)Ga-radiopharmaceuticals via the hybrid chelator DATA: clinical translation of [(68)Ga]Ga-DATA-TOC
  8. 88748
    “…In Case 3, however, serum sodium and glucose levels were normal when he initially became symptomatic. This case illustrates the importance of suspecting IAD in ICI-treated patients who present with non-specific symptoms, such as malaise, even in the absence of hyponatremia or hypoglycemia.…”
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    MON-348 Isolated ACTH Deficiency after Administrating Immune Checkpoint Inhibitors: Report of Three Cases and Review of Literature
  9. 88749
    por Wong, Beatrice, Shah, Nirali
    Publicado 2019
    “…This would shift the RANKL/OPG balance towards osteoclast differentiation and subsequent hypercalcemia. Our case illustrates effective treatment of hypercalcemia in myelofibrosis with denosumab 60 mg. …”
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    SAT-499 Denosumab for Treatment of Hypercalcemia in Myelofibrosis
  10. 88750
    “…Conclusions: This case illustrates a rare neurological presentation of hypercalcemia in a child. …”
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    SUN-LB049 Unusual Presentation of Large Parathyroid Adenoma with Acute Cerebellar Ataxia in a Pediatric Patient
  11. 88751
    “…Principally, we sought to illustrate the significance of longitudinal radiomic data acquisition for tissue response monitoring and provide a framework for future hypothesis driven research. …”
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    Serial T2-Weighted Magnetic Resonance Images Acquired on a 1.5 Tesla Magnetic Resonance Linear Accelerator Reveal Radiomic Feature Variation in Organs at Risk: An Exploratory Analysis of Novel Metrics of Tissue Response in Prostate Cancer
  12. 88752
    “…This difference is mostly driven by asymptomatic individuals with biological Alzheimer disease. These findings illustrate the magnitude of the consequences on public health that potentially exist by intervening with disease-specific treatments to prevent symptom onset.…”
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    Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework
  13. 88753
    “…Downregulation of miR-16 exhibited the opposite effect on p-NF-κB and p-IκBα expression levels. The present study illustrates that downregulation of miR-16 may protect against H/R-induced injury partially by targeting CIAPIN1 and the NF-κB signaling pathway.…”
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    Downregulation of miR-16 protects H9c2(2-1) cells against hypoxia/reoxygenation damage by targeting CIAPIN1 and regulating the NF-κB pathway
  14. 88754
    “…The differentially expressed gene profiles illustrated that intensive defense responses were significantly induced by vv + MDV at 10 dpi and 21 dpi but with slight changes in the resistant line. …”
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    RNA Sequencing revealed differentially expressed genes functionally associated with immunity and tumor suppression during latent phase infection of a vv + MDV in chickens
  15. 88755
    “…The microbiome analysis of the infant fecal samples may illustrate the influence that the microbiome of the MOM may have on the development of the infants’ gastrointestinal microbiota. …”
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    3268 A TL1 Team Approach to Personalizing Donor Human Milk for the Preterm Infant
  16. 88756
    “…However, the underlying mechanism remains to be illustrated. Protein arginine methylation transferase 5 (PRMT5), which mediates arginine methylation involved in the regulation of epigenetics, exhibits a variety of biological functions and essential roles in diseases. …”
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    Inhibition of PRMT5 Attenuates Oxidative Stress-Induced Pyroptosis via Activation of the Nrf2/HO-1 Signal Pathway in a Mouse Model of Renal Ischemia-Reperfusion Injury
  17. 88757
    “…Patient-derived xenograft (PDX) models of human pancreatic ductal adenocarcinoma (PDAC) were established to illustrate in vivo antitumor effects of the third-generation small molecule inhibitor specifically against ASPH’s β-hydroxylase activity. …”
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    Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway
  18. 88758
    “…Among patients not achieving low levels of disease activity across several composite indices, golimumab-randomized patients appeared to exhibit far less progression of structural damage than placebo-randomized PsA patients, illustrating a potential disconnect between responses, wherein golimumab can inhibit structural damage independent of clinical effect. …”
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    Inhibition of radiographic progression across levels of composite index-defined disease activity in patients with active psoriatic arthritis treated with intravenous golimumab: results from a phase-3, double-blind, placebo-controlled trial
  19. 88759
    “…Notre objectif est d’illustrer l’intérêt d’un TB pour réaliser une EPP. …”
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    B-01 Évaluation des Pratiques Professionnelles (EPP) et Tableau de Bord (TB) : exemple du Traitement des Pneumonies Aigues Communautaires (PAC)
  20. 88760
    “…Conclusion: TSHoma appears to be safely managed throughout pregnancy without the need of stopping octreotide, which seems not to adversely affect outcomes for the mother and the fetus. This case also illustrates the long-term management (16 years) of TSHoma with octreotide with excellent hormonal and structural response.…”
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    SAT-253 Long-Term Management and Successful Pregnancy of a Patient with a TSH Secreting Macroadenoma Treated with Octreotide
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